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Biomedical subjects

J B Griffin

Publications and source records attributed to J B Griffin.

At least 19 recordsLinked to original sources
PubMed2001

Biotinylation of histones in human cells. Effects of cell proliferation.

An enzymatic mechanism has been proposed by which biotinidase may catalyze biotinylation of histones. Here, human cells were found to covalently bind biotin to histones H1, H2A, H2B, H3, and H4. Cells respond to proliferation with increased biotinylation of histones; biotinylation increases early in the cell cycle and remains increased during the cycle. Notwithstanding the catalytic role of biotinidase in biotinylation of histones, mRNA encoding biotinidase and biotinidase activity did not parallel the increased biotinylation of histones in proliferating cells. Biotinylation of histones might be regulated by enzymes other than biotinidase or by the rate of histone debiotinylation.

Amidohydrolases↗
PubMed1990

Sensory nerve evoked responses in spinal cord injury.

Previous studies have documented the presence of fibrillations, positive waves, and decreased motor evoked response amplitudes in spinal cord injury (SCI) subjects. The purpose of this study was to further evaluate sensory nerve status in this population. Twenty-eight subjects with SCI for at least five months and evidence of spasticity were included. Sural sensory and tibial motor evoked response amplitudes were measured. The mean sural sensory amplitude was 8.0 +/- 5.9 microV (normal = 15.0 +/- 5.3 microV). The mean tibial motor amplitude was 5.1 +/- 4.3 mV (normal = 11.7 +/- 3.8 mV). In six subjects with significantly reduced sural sensory amplitudes, more extensive electrodiagnostic testing was performed. These studies showed diffusely decreased lower extremity sensory and motor evoked response amplitudes and diffuse positive waves and fibrillations in no particular distribution. Thus, subjects with SCI may have sensory as well as motor nerve abnormalities. An intact connection between the second order and primary sensory neuron may be necessary for maintenance of axonal integrity of the primary neuron.

Adolescent↗
PubMed1986

Internal vessel occlusion: an improved technique for small vessel anastomosis.

During infragenicular bypass, internal occlusion of the distal vessel avoids unnecessary dissection and potentially damaging use of external clamps or vessel loops while improving exposure and patency. This technique is especially useful in patients with small or calcific vessels in whom distal reconstruction is necessary for limb salvage.

Humans↗
PubMed1984

Studies of phosphorus metabolism by isolated nuclei. XII. Some fundamental properties of the incorporation of 32Pi into polyphosphate by rat liver nuclei.

Rat liver nuclei incubated in vitro catalyze a sustained incorporation of 32Pi into polyphosphate. A preliminary estimate indicates a minimal rate of 10 moles of Pi incorporation into polyphosphates/h/mg protein. Polyphosphate is the predominant acid-insoluble product of nuclear phosphorylation; its formation is dependent on the presence of a divalent cation and is catalyzed by a system or systems as yet uncharacterized.

Animals↗
PubMed1984

Pheochromocytoma in pregnancy: diagnosis and collaborative management.

Antenatal diagnosis and appropriate management of pheochromocytoma complicating pregnancy offers a reduction in mortality for both mother and fetus. We have presented the successful management of such a case, emphasizing the close collaboration between obstetricians, pediatricians, anesthesiologists, surgeons, and internists that is mandatory for a successful outcome.

Adrenal Gland Neoplasms↗
PubMed1983

Evaluating alcoholism and drug abuse knowledge in medical education: a collaborative project.

A series of six modular examinations, each representing a substance abuse problem, were developed by a National Institute on Drug Abuse task force working with consultants from the National Board of Medical Examiners (NBME). Each examination contained a patient management problem and multiple-choice questions. The examinations were administered to 629 third- and fourth-year U.S. medical students, and the results indicated that students performed less well in this area than on the traditional content of the NBME examinations. Students performed better on items related to pharmacologic effects of drugs of abuse, Alcoholics Anonymous, and the treatment of delirium tremens. Students did less well on items related to metabolic and biochemical areas; emergency room treatment of drug-overdosed, comatose patients; and legal issues in substance abuse. As a result of these data, a syllabus explaining each item in the available modules was developed, score-reporting to participating schools was modified, and the modules were shortened. Implications for medical education in substance abuse are discussed.

Alcoholism↗
PubMed1982

The calcar femorale redefined.

The calcar femorale is a spur of thickened bone that lies deep to the lesser trochanter but posterior to the neutral axis of the femoral neck. The calcar is thickest medially where it joins the compression buttress of the neck and gradually thins as it passes laterally. X-ray films taken at right angles to the neutral axis of the femoral neck best portray the calcar femorale, which stands out like a solid bone spur as if viewing along the line of a picket fence. The presence of the calcar femorale affects the configuration of peritrochanteric fractures. It should not be confused with the primary medial compression buttress of the femoral neck.

Femur Neck↗
PubMed1981

Tissue distribution of primaquine in the rat.

The distribution of primaquine was measured in seven rat tissues at 15-180 min after the intraperitoneal injection of the antimalarial 8-aminoquinoline. The half-life of unmetabolized primaquine was 4.0 h in lung, 1.7-1.9 h in blood, spleen, kidney and heart, and 1.2 h in liver. At each interval, the concentrations of unmetabolized primaquine were (in order): lung greater than liver, kidney, spleen greater than heart greater than brain greater than or equal to blood. At 3 h after the injection of [6-O-methyl-3H]primaquine, unmetabolized primaquine constituted 10% of the total 3H in blood and 40-60% of the total 3H in liver, brain, heart and kidney.

Animals↗
PubMed1977

Rumination in a 7-year-old child.

Regurgitation of food by rumination has rarely been reported in latency-age children. A 7-year-old boy had symptoms of rumination, gagging, bruxism, and enuresis. During the oppositional stage of development many unresolved conflicts had developed between the patient and his parents. Short-term psychotherapy which focused on resolution of the power struggles produced rapid remission of the symptoms. A two-year follow-up showed no recurrence of difficulty.

Adult↗