PubMed Health⌕ Search

Biomedical subjects

J B Grow

Publications and source records attributed to J B Grow.

17 recordsLinked to original sources
PubMed1986

Dose-response effects of intravenous ranitidine on gastric pH and volume in outpatients.

The dose-response effects of intravenous ranitidine given 45 min to 5 h earlier on gastric pH and volume were evaluated in six groups of 25 outpatients, each undergoing elective surgery under general anesthesia. Patients in Group 1 received no ranitidine and served as controls. Patients in Groups 2-6 received ranitidine intravenously in incremental doses of 0.5 mg X kg-1 body weight from 0.5 mg to 2.5 mg (Group 2, 0.5 mg; Group 3, 1.0 mg; Group 4, 1.5 mg; Group 5, 2.0 mg; and Group 6, 2.5 mg). Ninety-six per cent of patients in the control group (Group 1) had gastric pH less than or equal to 2.5 while 36% of the patients had gastric content volumes greater than or equal to 25 ml with pH less than or equal to 2.5. Ranitidine, in incremental doses of 05.-2.5 mg X kg-1 body weight, caused a significant reduction of gastric acidity and volume. The ED50 of ranitidine producing a gastric pH greater than 2.5 was 0.36 mg X kg-1, and the ED95 was 0.98 mg X kg-1 body weight. The ED95 of ranitidine producing a gastric volume less than 25 ml was 1.96 mg X kg-1. At the dose of 1.5 mg X kg-1 of ranitidine, 100% of the patients had gastric contents with pH greater than 2.5. The proportion of patients with volume less than 25 ml was 68% with ranitidine, 0.5 mg X kg-1, and gradually increased to 100% with 2.5 mg X kg-1 body weight.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1985

Bicitra (sodium citrate) and metoclopramide in outpatient anesthesia for prophylaxis against aspiration pneumonitis.

To evaluate the effect of Bicitra (Willen Drug Company, Baltimore, Maryland), a commercial preparation of sodium citrate and metoclopramide, on gastric contents 150 elective outpatients allocated into six groups with 25 patients in each group were studied. Patients in Group 1 served as controls. Patients in Groups 2, 3, 5, and 6 received Bicitra, po, either 15 ml (Groups 2 and 5) or 30 ml (Groups 3 and 6). In addition, patients in Groups 5 and 6 also received metoclopramide 10 mg, iv; Group 4 patients received metoclopramide 10 mg, iv. Eighty-eight per cent of patients in the control group had a gastric pH less than or equal to 2.5, while 36% had a gastric content volume greater than or equal to 25 ml with pH less than or equal to 2.5. Bicitra, 15 ml and 30 ml, po, increased mean gastric pH and decreased the proportion of patients with a gastric pH less than or equal to 2.5 to 32 and 16%, respectively, in Groups 2 and 3. However, Bicitra 15 ml and 30 ml, increased the mean gastric volume in Group 3 and also increased the proportion of patients with a gastric volume greater than or equal to 25 ml to 56% in Group 2 and 84% in Group 3. The addition of metoclopramide 10 mg, iv, to Bicitra reduced the proportion of patients with a gastric volume greater than or equal to 25 ml in Groups 5 and 6 to 28 and 36%, respectively. Metoclopramide (Group 6) independently reduced mean gastric volume (15.6 ml vs. 32.7 ml) and the proportion of patients with a gastric volume greater than or equal to 25 ml (20% vs. 36%). Bicitra and metoclopramide combination significantly reduced the proportion of patients with gastric contents greater than or equal to 25 ml with pH less than or equal to 2.5.

Adult↗
PubMed1982

Subglottic stenosis after cricothyroidotomy.

Analysis of the case histories of 17 patients who developed subglottic obstruction following cricothyroidotomy shows that all 10 patients with chronic stenosis had acute laryngeal pathology at the time of initial operation. Seven patients were identified as having acute subglottic obstruction with granulation tissue. Although these patients were effectively managed by local means, ineffective management of intratracheal granulation tissue may convert a minor, temporary problem into a serious chronic obstruction. Cricothyroidotomy is appropriately used for prolonged airway access only in patients free of acute laryngeal pathology.

Adolescent↗
PubMed1976

Extended use of intra-aortic balloon pumping in peripartum cardiomyopathy.

A patient with perinatal cardiomyopathy was greatly benefited physiologically by 7 weeks of intra-aortic balloon pumping. This experience documented that extended pumping can be carried out with only manageable complications. Although the patient survived the hospitalization, she died shortly thereafter of intractable congestive failure. Perinatal cardiomyopathy is a potentially reversible condition. Ventricular assistance by intra-aortic balloon pumping may be sustaining during continued systemic treatment of this entity. Further evaluation for longevity of more advanced congestive heart failure from cardiomyopathies needs further clinical trial.

Adult↗
PubMed1976

Cricothyroidotomy: elective use in respiratory problems requiring tracheotomy.

Surgical teachings insist that cricothyroidotomy should be performed only under emergency conditions as a temporary means of securing an airway. Subsequent subglottic stenosis is thought to occur in alarming numbers of patients intubated for any length of time. The incidence of complications associated with cricothyroidotomy has not been critically examined since Jackson's classic paper in 1921, condemning the operation. A total of 655 patients with cricothyroidotomy tubes in place from hours to months were studied to determine the incidence of problems associated with this procedure. The over-all complication rate was 6.1 per cent. There was one cricothyroidotomy-associated death. Chronic subglottic stenosis did not occur, although 5 patients required resection of tracheal strictures. No additional complications occurred if the procedure was carried out at the bedside instead of in the operating room. The simplicity, absence of cross-contamination of median sternotomy incisions, and safety documented by this study recommend routine use of cricothyroidotomy in patients whose management requires tracheotomy.

Adolescent↗
PubMed1976

Myocardial infarction complicated by rheumatic heart disease.

This report describes the case of a 32-year-old woman with the sudden onset of chest pain and an evolving inferior wall infarction proved by the electrocardiogram and enzyme studies. The patient underwent embolectomy 2 months later for a thromboembolus in the right main coronary artery. An autologous patch graft was used to close the arteriotomy. Four years later, the patient is asymptomatic, having no activity limitations. The patch graft to the right coronary artery is patent. This case exemplifies and reaffirms the possibility of emboli being lodged in the coronary arteries in certain types of disease. It may be necessary to operate in order to re-establish proper coronary circulation.

Adult↗