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Biomedical subjects

J B Hawkins

Publications and source records attributed to J B Hawkins.

12 recordsLinked to original sources
PubMed1994

Myopathy with ragged red fibres following renal transplantation: possible role of cyclosporin-induced hypomagnesaemia.

A 65-year-old man developed a painless proximal myopathy 7 years after commencing cyclosporin therapy following a successful cadaveric renal transplant. Muscle histology showed ragged red fibres and biochemical studies suggested mitochondrial dysfunction. The possible pathogenesis of this mitochondrial myopathy, particularly its relationship to cyclosporin-induced hypomagnesaemia, is discussed.

Aged↗
PubMed1969

Iron metabolism in the anaemia of chronic renal failure. Effects of dialysis and of parenteral iron.

Serial studies of iron transport in patients on maintenance dialysis showed normal or raised values in almost all subjects and a transient increase soon after the start of dialysis in three. These patients, who were seldom or never transfused, had low serum iron levels and normal iron-binding capacity with low saturation. Iron transport was substantially increased by parenteral iron-dextran treatment. Tracer studies showed good iron utilization, with transport to the marrow rather than to the liver. In these circumstances iron therapy is safe and beneficial, and a useful rise in red cell mass was shown to result from it. The packed cell volume was found to be a valid index of red cell mass in these patients. Red cell loss in the dialysers was insufficient to account for the observed reduction in red cell survival.

Adult↗
PubMed1969

Lithium.

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Bipolar Disorder↗