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Biomedical subjects

J B Hertz

Publications and source records attributed to J B Hertz.

13 recordsLinked to original sources
PubMed1992

Time-related decrease in diffusion capacity in HIV-infected patients with impaired immune function.

The purpose of this study was to investigate acute and time-related changes in lung function, i.e. forced expiratory volume in 1 second (FEV1), vital capacity (VC) and transfer factor (KCO) in HIV-infected patients with CD4 cell counts less than 400 x 10(6)/l. 66 males with no history of HIV-related pulmonary symptoms participated in a prospective lung function study for 9 months with 3-month intervals between examinations. 15/66 patients (23%) developed acute pulmonary symptoms, i.e. dyspnea (n = 12), cough (n = 13), fever greater than 38 degrees C (n = 13) and interstitial infiltrates on the X-ray (n = 9). Among the 51 asymptomatic patients, a significant time-related decrease in KCO (median decrease of 7%) was found, whereas no significant change in FEV1 or VC was observed during the study. Baseline KCO, i.e. KCO at entry, was found to be significantly higher in the asymptomatic patients (102% predicted (pred.) than in those patients who developed pneumonia (88% pred.). Development of pulmonary symptoms was both followed by a significant decrease in KCO (median decrease 17%), FEV1 and VC. We therefore conclude that HIV-infected patients with impaired immune function have in the absence of pulmonary symptoms a decrease in KCO. In case of pneumonia an acute decrease in both KCO, FEV1 and VC occurs.

Adult↗
PubMed1992

Hormonal and menstrual changes after laparoscopic sterilization by Falope-rings or Filshie-clips.

OBJECTIVE: To evaluate the influence of laparoscopic sterilization by Falope-rings (Cabot Medical Corp., Langhorne, PA) or Filshie-clips (Femcare, Nottingham, United Kingdom) on menstrual pattern and ovulatory function. DESIGN: A prospective, nonrandomized study of women sterilized by Falope-rings (n = 6) or Filshie-clips (n = 5). Menstrual charts were kept. Serum follicle-stimulating hormone (FSH), estradiol (E2) and progesterone (P) were measured by means of radioimmunoassay in one cycle before and 3, 6, and 12 months after the sterilization. Blood samples were drawn on day -6, -2, 0, +6, +10 of the menstrual cycle, ovulation corresponding to day 0. The women sterilized by Filshie-clips had abdominal ultrasonography of the ovaries measuring the leading follicle on day -6, -2, 0, +6 of the menstrual cycle. PATIENTS: Twelve women, 25 to 38 years old, with regular menstrual cycles and no use of oral contraceptives or intrauterine contraceptive device at least 6 months before sterilization. One woman was excluded. RESULTS: After the sterilization, all women reported unchanged menstrual pattern. The follicular rise in E2 unchanged, and FSH levels fell accordingly. Progesterone levels were ovulatory, but the midluteal P peak 3 months poststerilization was significantly decreased. Serial abdominal ultrasonography in women sterilized by Filshie-clips confirmed ovulation in all cycles except in one woman, who had an unruptured follicle in one cycle before and in the sixth cycle after sterilization. CONCLUSION: Laparoscopic sterilization by Falope-rings or Filshie-clips does not seem to interfere with menstrual pattern or ovulatory function.

Adult↗
PubMed1979

Cross-reactions between Staphylococcus aureus and fifteen other bacterial species.

Fifty-five different antigens were demonstrated in an antigen preparation obtained by sonication of a protein A-free strain of Staphylococcus aureus, using crossed immunoelectrophoresis and antiserum obtained from rabbits. The antigens were characterized by absorption experiments with formalin-killed bacterial cells, temperature resistance and protein and polysaccharide staining. One of the antigens showed reaction of identity with a preparation of teichoic acid from S. aureus. Using this reference system, cross-reactions between the S. aureus reference strain and S. aureus strains from the four phage groups as well as 15 other bacterial species, were studied by various quantitative immunoelectrophoretic methods. The S. aureus antigens from the four phage groups showed almost 100% cross-reactivity for all antigens, while antigens from nine other bacterial species cross-reacted to varying degrees with one to four S. aureus antigens. All of 12 S. aureus antigens cross-reacted with the four S. epidermidis biotypes.

Antigens, Bacterial↗
PubMed1979

Cross-reactions between Haemophilus influenzae and nineteen other bacterial species.

Forty-one different antigens were demonstrated in an antigen preparation obtained by sonication of a Haemophilus influenzae (H. influenzae) type b strain, using crossed immunoelectrophoresis and antiserum obtained from rabbits. Antigens were characterized by absorption experiments with whole heat-killed bacteria, temperature resistance and protein and polysaccharide staining. Cross-reactions between H. influenzae type b and 19 other bacterial species were studied by various quantitative immunoelectrophoretic methods, using the reference system. A non-capsulated H. influenzae cross-reacted extensively (41 antigens) with H. influenzae type b and Haemophilus parainfluenzae, and Haemophilus haemolyticus showed considerable cross-reactivity with H. influenzae type b (26 and 32 antigens respectively), while antigens from eight other bacterial species cross-reacted to varying degrees with one to five H. influenzae antigens.

Antigens, Bacterial↗
PubMed1979

Estradiol, estriol and human placental lactogen in serum in threatened abortion.

In 64 pregnant women admitted to hospital because of threatened abortion the prognostic value of estradiol-17-beta, estriol and human placental lactogen (HPL) in serum was examined. The hormones were determined by radioimmunoassay. Blood samples were taken at regular intervals during admission to hospital and subsequently until delivery. For each hormone a reference range was based on the hormone values obtained from the pregnancies that continued to viability. The study shows that the three hormones examined gave a good indication of the prognosis in threatened abortion, both separately and in combination. The best predictive values were achieved with estradiol and HPL after serial samples. Of these two hormones estradiol is to be preferred because of its fetoplacental origin.

Abortion, Threatened↗
PubMed1977

In vitro stimulation of human lymphocytes by Bordetella Pertussis.

Bordetella pertussis (B.p.) induces blast transformation of human lymphocytes; whole killed B.p. are more efficient than extracts obtained by sonication. Similar responses were obtained with each of the four strains used in the Danish pertussis vaccine. B.p. with low amounts of Protective Antigen and Histamine-Sensitizing Factor also induced lymphocyte transformation, but were less toxic to the lymphocytes at high concentrations. The supernatants of B.p. cultures were purified with respect to Lymphocytosis Promoting Factor; evidence is presented that these purified fractions possess T-lymphocyte mitogenic activity. Lymphocytes from all normal humans were stimulated by B.p., including cells from cord blood. Cells from childbearing women, obtained immediately after delivery, showed a general depression of lymphocyte transformation including the response to B.p. Children with whooping cough had a lower lymphocyte response to B.p. than healthy children. A highly significant correlation was observed between the responses to B.p. and to E. coli in the adults and newborn examined. It is concluded that the major part of the lymphocyte transformation induced by B.p. is non-specific.

Adult↗
PubMed1976

Crossed immunoelectrophoretic analysis of Bordetella pertussis antigens and of corresponding antibodies in human sera.

Fourty-four antigens were demonstrated in sonicated preparations of Bordetella pertussis (B.p.), using crossed immunoelectrophoresis against antiserum obtained from rabbits. No qualititative differences between the four strains of the Danish pertussis vaccine were found. In preparations of B.p. culture medium, purified with respect to Lymphocytosis Promoting Factor (LPF) activity, one antigen was possibly related to LPF. In human sera, antibodies against five of the B.p. antigens were demonstrated by means of crossed immunoelectrophoresis with intermediate gel. Antibody production was demonstrable in children during the pertussis vaccination period and was most marked after the second vaccination.

Antibodies, Bacterial↗
PubMed1976

Cross-reactions between Bordetella pertussis and twenty-eight other bacterial species.

Cross-reactions between B. pertussis and 28 other bacterial species were studied by various quantitative immunoelectrophoretic methods. A sonicated B. pertussis antigen preparation and a corresponding pooled rabbit antiserum were used as reference system. Two of the B. pertussis antigens were cross-reactive with antigens from 17, respectively 19, other bacterial species mainly gram-negative species. As judged by absorption of antibodies, the degree of cross-reactivity of these B. pertussis antigens with antigens from other species was found to be in the range 25-30%. Antigens from B. parapertussis and B. bronchiseptica were found to cross-react very extensively with B. pertussis, and only 4, respectively 2, of the 44 antigens of the B. pertussis reference system could not be absorbed with antigens from these two Bordetella species.

Antibodies, Bacterial↗