PubMed Health⌕ Search

Biomedical subjects

J B Holme

Publications and source records attributed to J B Holme.

6 recordsLinked to original sources
PubMed1990

Comparison of one dose versus three doses of prophylactic antibiotics, and the influence of blood transfusion, on infectious complications in acute and elective colorectal surgery.

In a randomized prospective controlled trial involving 311 patients undergoing acute or elective colorectal surgery, the efficacy and safety of two different single dose and one triple dose regimen of antibiotic prophylaxis, as well as the influence of blood transfusion on postoperative infectious complications, were studied. Postoperative infectious complications occurred in a total of 59 patients (19.0 per cent). There were no major differences between the three treatment groups. Thirty-four patients (10.9 per cent) developed abdominal wound infection, 17 patients (5.5 per cent) intra-abdominal abscess and 16 patients (5.1 per cent) anastomotic leakage. Of 202 patients (65.0 per cent) requiring blood transfusion during hospitalization 57 (28.2 per cent; 95 per cent confidence limits of 23-36 per cent) developed infectious complications, whereas two non-transfused patients (1.8 per cent; 95 per cent confidence limits of 0.2 to 6 per cent; P less than 0.001) developed infectious complications. It is concluded that one single dose of antibiotic prophylaxis in acute and elective colorectal surgery is as protective as a triple dose regimen. The development of infectious complications despite antibiotic prophylaxis is strongly related to blood transfusion.

Adolescent↗
PubMed1990

Incidence of lesions of the saphenous nerve after partial or complete stripping of the long saphenous vein.

To find out whether the usual total stripping of the long saphenous vein in operations for varicose veins could be replaced by a less traumatic removal of only the femoral part of the vein, a randomised prospective study was carried out in 163 consecutive patients, of whom 157 were evaluable. Group A (n = 80) had total stripping and group B (n = 77) had partial stripping (extraction of the long saphenous vein from the groin to immediately below the knee). The two groups, which were comparable, were assessed three months after operation when 75 in group A (94%) and 75 in group B (97%) had excellent or good relief of symptoms and comparable absence of residual varicosities. Lesions of the saphenous nerve were found in 31 in group A (39%) and 5 in group B (7%) (p less than 0.001). There were few other complications. We conclude that preservation of the distal long saphenous vein not only reduces nerve damage, but also retains enough vein for use should coronary artery bypass or peripheral vascular grafting be necessary in future.

Adult↗
PubMed1986

[Transfixion].

Explore the source record for details and available documents.

Accidental Falls↗
PubMedDate not supplied

The anatomic relationship between the long saphenous vein and the saphenous nerve. Relevance for radical varicose vein surgery.

Radical surgery for varicose veins often includes total stripping of the long saphenous vein. Some surgeons now claim, however, that stripping of the distal part of that vein can be avoided, thereby reducing the risk of damage to the saphenous nerve. Dissection of 60 cadaver legs to demonstrate the relationship between the long saphenous vein and the saphenous nerve indicated that stripping performed from the groin to immediately below the knee would minimize the risk of nerve damage.

Female↗