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Biomedical subjects

J B Jacobsen

Publications and source records attributed to J B Jacobsen.

17 recordsLinked to original sources
PubMed1987

The influence of theophylline and phenobarbital on rat brain 5'-nucleotidase.

Xanthines and barbiturates have opposing effects on cerebral function and metabolism. Since the xanthine theophylline is known to inhibit the enzyme 5'-nucleotidase, and thus endogenic adenosine release, an in vitro experiment was conducted on the assumption that theophylline and phenobarbital may have an opposing effect on 5'-nucleotidase activity. This assumption was confirmed. The hypothesis that barbiturates in general cause an increase in endogenic adenosine release seems compatible with the known functional and metabolic effects of barbiturates. Furthermore, accepting the hypothesis that cellular hypoxic-anoxic survival may ultimately depend on salvage of adenine nucleotides, this may even explain the dichotomy in the effect of barbiturates when used for protection of a hypoxic-anoxic insult.

5'-Nucleotidase↗
PubMed1980

Cross-infection from contaminated anaesthetic equipment. A real hazard?

A definite relationship between the use of contaminated anaesthetic equipment and subsequent pulmonary infection remains to be established. There is however indirect and circumstantial evidence suggesting that cross-infection may occur, and further an increased susceptibility of surgical patients to pulmonary infections has been demonstrated. Decontamination should be recommended before the equipment is re-used. Pasteurisation may prove sufficient and this can be obtained employing a specially designed dish-washing machine.

Anesthesia, Inhalation↗
PubMed1980

Efficiency of two variable performance techniques of oxygen therapy in relieving postoperative hypoxaemia.

The efficiency of two patient-dependent, variable performance techniques of oxygen therapy in relieving hypoxaemia after upper abdominal surgery was compared. A high-flow system delivered a humidified mixture of oxygen 2 litre min-1 and air 13 litre min-1 through a cannula inserted into the anterior nares. The low-flow system delivered 2 litre min-1 of dry oxygen into the nasopharynx through a catheter. Thirteen otherwise healthy patients received either high-flow oxygen therapy for 30 min followed by low-flow oxygen therapy for a further 30 min after operation or the same therapy in reverse order. With the patients breathing room air, arterial hypoxaemia could be demonstrated with Pao2 inversely related to age. The increase of Pao2 during either oxygen treatment was significantly greater with the low flow system.

Adult↗