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Biomedical subjects

J B Kessel

Publications and source records attributed to J B Kessel.

4 recordsLinked to original sources
PubMed1992

Neurotoxicity related to lithium and neuroleptic combinations? A retrospective review.

The question of toxic interactions resulting from combinations of lithium and neuroleptic drugs is largely based on anecdotal reports. We replicated the methods of Miller and Menninger (1987) who reported that 27% of manic patients on treatment with lithium and neuroleptics developed toxicity. We found no cases of neurotoxicity as defined in the earlier report. Pharmacologic mechanisms and differences in the clinical findings of the two studies are discussed.

Antipsychotic Agents↗
PubMed1991

Pharmacokinetics of neuroleptics.

Older studies on neuroleptic pharmacokinetics had problems in methodology and laboratory techniques. High performance liquid chromatography (HPLC) and combinations of techniques are used now. Clozapine levels are related to dose, age, sex, and smoking. Fluphenazine decanoate gives more predictable levels than oral, and 25 mg/2 weeks is associated with the lowest relapse rate. A therapeutic window with haloperidol is not well established; increased side effects at higher doses may account for the worsening seen. Half-lives much longer than previously quoted are now described. Children and the elderly are more susceptible to side effects of neuroleptics. Studies of the neuroleptic threshold and brain imaging indicate that doses used today are excessive. Nonresponders can distort dose effect relationships. Plasma levels are not useful routinely; they are of use in ruling out pharmacokinetic factors in nonresponse and when side effects are severe.

Antipsychotic Agents↗
PubMed1979

Chronic occlusion of the monkey fallopian tube with silicone polymer.

Investigators have previously reported good retention, antifertility efficacy, and oviduct polymer compatibility in rabbit oviducts in studies of both short-term and chronic occlusion with high viscosity silicone polymer. The present study attempts to determine the chronic effects of the silicone polymer installed into the oviducts of 10 rhesus monkeys. Unlike former studies with rabbits, the polymer was installed into the fimbrial end of the monkey's oviducts because of the complexity of the uterotubal junction's musculature. Studies with light and scanning electron microscopy were conducted to examine tissue reaction to plug retention. Despite our major modification of the installation technique, we obtained a retention rate of 50%. In addition, there was no evidence of inflammation or tissue distortion, and the polymer plugs were not affected by menstrual bleeding.

Animals↗