Biomedical subjects
Publications and source records attributed to J B Lipschutz.
Bronchoalveolar lavage demonstrated a flux of neutrophils into the lung of a patient with procainamide-induced lupus pulmonary disease. Serial lavage studies have shown persistent low-grade alveolitis despite the absence of clinical, serologic, and radiographic evidence of disease activity.
An elevated PaCO2 is distinctly unusual in pulmonary embolic disease. We report 2 patients with massive pulmonary emboli complicated by hypercapnia in the absence of underlying chronic obstructive lung disease. Profound alterations in ventilation/perfusion matching and reduced cardiac output are probable mechanisms of this gas-exchange problem.
The present report describes a patient who had severe obstructive lung disease in association with acquired hypogammaglobulinemia. Evidence obtained by bronchoalveolar lavage is presented that suggests that his lung disease resulted from both a marked increase in elastase load and a reduction in protease inhibitor function.