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Biomedical subjects

J B Messenger

Publications and source records attributed to J B Messenger.

At least 19 recordsLinked to original sources
PubMed1992

[14C]deoxyglucose labelling of functional activity in the cephalopod central nervous system.

For the first time, the [14C]deoxyglucose radioautographic technique has been successfully used to map physiological activity in cephalopod brains. In unilaterally blinded octopus and cuttlefish, the optic lobe of the deprived side showed a decreased uptake of the labelled tracer. This suggests that the uptake is related to functional activity. The potential of the [14C]deoxyglucose technique as a powerful tool in studying the functional organization of cephalopod brains is discussed.

Animals↗
PubMed1989

New evidence that L-glutamate is a transmitter at the squid giant synapse.

Experiments are described showing unequivocally that transmission at the squid giant synapse can be reversibly blocked by L-glutamate and its agonists kainate, quisqualate and AMPA, though not by NMDA. This effect is presumably brought about by desensitization. The glutamate antagonists cis-2,3-PDA, GAMS and the new quinoxalinediones CNQX and DNQX are also potent reversible blockers. These findings provide new evidence that L-glutamate is a transmitter at the giant synapse and further suggest that the glutamate receptor may be of the non-NMDA type.

Action Potentials↗
PubMed1985

Magnesium chloride as an anaesthetic for cephalopods.

Magnesium chloride is an effective anaesthetic and narcotizing agent for cephalopod molluscs. Individuals belonging to five genera (decapod and octopod) were anaesthetized and subsequently revived at temperatures ranging from 13 to 22 degrees C. At no stage of anaesthesia does MgCl2 appear to cause any trauma. There is evidence that MgCl2 acts centrally on the nervous system to induce anaesthesia. This salt, cheap, readily available and convenient to use, is recommended over urethane or ethanol as a suitable anaesthetic or narcotic for use with cephalopods.

Anesthetics↗