Biomedical subjects
Publications and source records attributed to J B Mulder.
A simple device was fabricated from a single piece of plastic to restrain several different species of rodents. The device served as a useful adjunct for numerous research, medical and teaching applications.
Explore the source record for details and available documents.
Ketamine and xylazine were combined to provide anesthesia for coyotes. The drugs were tested in eight adult animals divided equally by sex. A dosage combining 5.5 mg./kg. of each drug provided effective anesthesia for periods from 45 to 60 min.
An anesthetic combination of ketamine and promazine was tested in 25 male and 25 female mice of each of two strains. The mean induction time was 5 minutes for the C57BL/6We mouse and 8 minutes for the DBA/2We mouse. No sex differences were observed. The mean duration time was 45 minutes for the C57BL/6We male, 53 minutes for the C57BL/TWe female, 29 minutes for the DBA/2We male, and 35 minutes for the DBA/2We female. The mean recovery time was 39 minutes for the C57BL/6We male, 38 minutes for the C57BL/6We female, 21 minutes for the DBA/2We male, and 24 minutes for the DBA/2We female. The drug combination provided effective anesthesia for these strains of the laboratory mouse for a period of 30--50 minutes after a single intramuscular injection.
An anesthetic combination of ketamine and promazine (75mg/kg by ketamine content) was tested in 15 male and 15 female adult New Zealand white rabbits. The mean induction time was 9 minutes for both the male and female. Mean duration for anesthesia was 61 minutes for the male and 49 minutes for the female. The mean recovery time was 22 minutes for the male and 33 minutes for the female. The drug combination provided effective anesthesia for a period of 50--60 minutes after a single intramuscular injection.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Half-time disappearance of (51)Cr-laeled erythrocytes was studied in 39 Sinclair miniature swine at 20 to 46 days of age and again at 79 to 109 days of age. Mean erythrocyte half-time disappearance, disregarding age, was 21.29 (+/-0.77) days for males and 22.04 (+/-0.81) days for females. The half-time difference between males and females was not statistically significant (P<0.05). At 20 to 46 days of age the mean erythrocyte half-time disappearance was 19.56 (+/-1.41) days. The same pigs, tested at 79 to 109 days of age, had a mean erythrocyte half-time disappearance of 23.95 (+/-1.94) days. There was a significant difference (P<0.01) in erythrocyte half-time disappearance from miniature swine as the result of age and also for age within sex. The grand mean erythrocyte half-time disappearance, for all the miniature swine tested, was 21.67 (+/-0.54) days. The estimate of heritability was 0.61 for dam effect at 20 to 46 days of age and 0.06 at 79 to 109 days of age. Sire estimate of heritability was 0 at both age groups. It was concluded that the large heritability coefficient found only for dam component in young nursing pigs was the result of maternal environment rather than additive genetic variance.
Half-time disappearance of (51)Cr-labeled erythrocytes from 20 adult miniature swine was measured. Seven males and 13 females from 388 to 418 days of age, having a mean weight of 55kg were studied. Five ml of blood collected from each animal were labeled with 75 microCi (51)Cr at room temperature for 60 to 90 min. Following injection of the labeled erythrocytes into each animal, blood samples were collected every four to six days. Specific activity was measured and half-time disappearance determined by linear regression. The results were compared with values obtained from the same animals tested at two earlier ages. No significant (P <0.05) difference in erythrocyte half-time disappearance was detected between males and females at the three different ages. Mean (+/-SEM) erythrocyte half-time disappearance values were: 20 to 46 days of age, 19.58 (+/-0.59) days; 79 to 109 days of age, 23.56 (+/-1.18) days; and 388 to 418 days of age, 22.35 (+/-0.72) days. A significant (P <0.01) difference in erythrocyte half-time disappearance was found between the miniature swine tested at 20 to 46 days of age and those tested at either 79 to 109 or 388 to 418 days of age. No significant (P <0.05) difference in erythrocyte half-time disappearance was found between the two older age groups.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.