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Biomedical subjects

J B Nelson

Publications and source records attributed to J B Nelson.

6 recordsLinked to original sources

Computed tomography in the initial evaluation of patients with blunt trauma.

Two hundred sixty-six of 374 consecutive blunt trauma patients underwent emergency computed tomographic (CT) scanning during evaluation at a level I trauma center. The purpose of this study was to develop guidelines for use of CT scanning in the initial evaluation of blunt trauma patients. Of the 131 CT scans of the head obtained, 20 (15%) had positive results. Seven patients whose initial neurologic examinations were normal had abnormal results on head CT scans; none required emergent treatment of their head injury. This suggests that, in the presence of a normal neurologic examination, head CT scans can safely be delayed until other more serious injuries are addressed. Twenty-six CT scans of the chest were performed and ten (38%) were interpreted as abnormal. Chest CT scans provided information about the extent of the injury but did not alter the initial management of any patient and therefore are rarely indicated in the acute evaluation of trauma patients. A total of 110 abdominopelvic CT scans were performed and 20 (19%) were interpreted as positive. Seventy-five percent of those patients with positive CT scans were treated successfully in a nonsurgical fashion.

Chicago

Upper esophageal motility disorders.

This article begins with a summary of the anatomy and physiology of the upper esophageal region. The appropriate diagnostic tools used in the evaluation of upper esophageal motility disorders are then detailed including cineradiography, manometry, and other modalities. Specific clinical disorders associated with pharyngeal, UES, or upper esophageal dysfunction are described followed by a section on treatment.

Animals

Antisomatogyral illusion.

Following voluntary ambulatory turning (eight turns), perceived motion is reversed in direction relative to a) aftereffects of passive rotation and b) predictions from current concepts of immer ear function. Following active turning, feedback from reflexes elicited by vestibulospinal activity apparently dominates the perceptual experience. Practical consequences in medicine and aviation are discussed.

Adult

Effects of changes in the concentrations of substrate and oxygen on the perfused rabbit heart.

Rabbit hearts were perfused with bicarbonate-buffered fluid containing 1.0 mM glucose and 1.5 mM lactate. Pairs of redox substrates were measured in the perfusion fluid and the heart after perfusate concentrations of beta-hydroxybutyrate (beta-HB) and oxygen were varied. The perfusate lactate to pyruvate ratio was shown to accurately represent the tissue ratio. The intracellular redox state varied independently of changes in substrate uptake. Increasing perfusate beta-HB concentration caused increased beta-HB uptake, decreased lactate uptake, and unchanged glucose uptake. Decreased perfusate oxygen tension caused inhibition of lactate and beta-HB uptakes and, when exteme, caused increased glucose uptake. The combination of a modest reduction in oxygen tension and increased perfusate beta-HB concentration caused a more reduced environment in the tissue than either change by itself. This combination of changes may have additive deleterious effects as suggested by clinical observations.

Animals