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Biomedical subjects

J B Norton

Publications and source records attributed to J B Norton.

At least 19 recordsLinked to original sources
PubMed1987

Double-outlet right ventricle and severe systemic outflow tract hypoplasia.

Double-outlet right ventricle and severe systemic outflow tract hypoplasia comprises a subset of patients in whom total correction or palliation requires complex surgical procedures in the neonatal period. Our experience with 3 patients illustrates the difficulties associated with treatment and suggests possible surgical options for this otherwise lethal variant of the Taussig-Bing syndrome.

Aorta, Thoracic↗
PubMed1986

Cardiovascular and respiratory effects of ketamine in the neonatal lamb.

To determine the cardiovascular and respiratory effects of intravenous ketamine in the neonatal lamb we studied six unpremedicated chronic neonatal lamb preparations. Each lamb was anaesthetized with ketamine 15 mg [corrected] X kg-1, allowed to recover and then anaesthetized with ketamine 30 mg [corrected] X kg-1. Mean arterial pressure, mean pulmonary artery pressure, mean left atrial pressure, pulmonary bloodflow, heart rate, respiratory rate and arterial blood gases were measured before and at one, two, four, six, eight and ten minutes after the administration of each dose of ketamine. Pulmonary vascular resistance, systemic vascular resistance and the ratio of pulmonary to systemic vascular resistance were also determined. After the administration of either dose of ketamine, only respiratory rate changed significantly (p less than or equal to 0.05), reaching a maximum after two minutes. This change was not associated with any arterial blood gas abnormalities. We conclude that in the presence of adequate ventilation, ketamine produces no significant cardiovascular effects in neonatal lambs.

Animals↗
PubMed1986

Attenuated pulmonary vascular obstructive disease in double-outlet right ventricle and mitral stenosis.

A young woman with double-outlet right ventricle, mitral stenosis, and high systemic pulmonary artery pressure is described. Pulmonary vascular morphometric analysis indicated considerably less pulmonary vascular obstructive disease than might otherwise have been expected. Total repair was performed and resulted in a marked fall in pulmonary artery pressure. Pulmonary vascular morphometry may be indicated in selected patients before palliative management is selected over complete repair.

Adult↗
PubMed1983

Renovascular hypertension in an infant with segmental renal artery stenosis and hypoplasia of the abdominal aorta.

Hypoplasia of the abdominal aorta is a rare cause of renovascular hypertension. Arteriographic studies of the renal vasculature are presented from an infant with hypoplasia of the abdominal aorta and segmental renal artery stenosis. The renovascular hypertension was cured by partial nephrectomy. There was no difference in the parenchymal histology in the tissue from the congenitally ischemic lower pole of the kidney and the vascularized upper pole. In this unique case with decreased renal blood flow during fetal development there was no evidence that parenchymal ischemia can cause renal parenchymal hypoplasia.

Aorta, Abdominal↗