This article reviews the course of development of research on a currently popular explanatory approach to dysfunctional behavior, the learned helplessness analysis. The early history is prominent in this review as it reflects the inspirations of Richard L. Solomon, a scholar who fostered the resurgence of psychologists' interests in Pavlovian conditioning in the 1950s and 1960s. Current research is characterized as having four separate themes: elaboration of "symptoms," elucidating the role of fear, explicit modeling, and extensions involving attributional constructs.

Animals↗

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Conditional choice-unique outcomes establish expectancies that mediate choice behavior.

Conditional discriminative choice tasks can be arranged such that all correct choices yield the same reinforcer or such that each type of correct choice has its own unique reinforcer. The former is the traditional "Common Outcomes" Procedure; the latter is the "Differential Outcomes" Procedure. Use of this Differential Outcomes Procedure facilitates the rate of learning, increases the asymptotic level of performance, and enhances working-memory based performances in both animals and humans. These facts have stimulated many questions and experiments about learning and memory mechanisms and fostered potential applications.

Animals↗

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Differential Pavlovian fear conditioning as a function of the qualitative nature of the UCS: constant versus pulsating shock.

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Avoidance Learning↗

PubMedDate not supplied

The neurobiology of stress ulcers.

We have reviewed the neurobiology of stress ulcers from animal models to potential pharmacotherapeutic mechanisms. The evidence strongly supports the hypothesis that certain stress-related gastric lesions are 'brain-driven' events which may be more effectively managed through central manipulations than by altering local, gastric factors. Recent advances in the use of anxiolytic and antidepressant drugs in the management of stress-related gastric mucosal injury further supports the contention that a brain-gut axis, which may have nervous, peptidergic and classic monoaminergic components, modulates the intricate and complicated pattern of communication between the brain and the stomach. Delineation of the precise pathways which make up this communication as well as their manipulation by various pharmacological agents will be the focus of future research endeavour.

Animals↗

PubMedDate not supplied

Ibuprofen effects on Alzheimer pathology and open field activity in APPsw transgenic mice.

We previously showed the non-steroidal anti-inflammatory drug (NSAID) ibuprofen suppresses inflammation and amyloid in the APPsw (Tg2576) Tg2576 transgenic mouse. The mechanism for these effects and the impact on behavior are unknown. We now show ibuprofen's effects were not mediated by alterations in amyloid precursor protein (APP) expression or oxidative damage (carbonyls). Six months ibuprofen treatment in Tg+ females caused a decrease in open field behavior (p < 0.05), restoring values similar to Tg- mice. Reduced caspase activation per plaque provided further evidence for a neuroprotective action of ibuprofen. The impact of a shorter 3 month duration ibuprofen trial, beginning at a later age (from 14 to 17 months), was also investigated. Repeated measures ANOVA of Abeta levels (soluble and insoluble) demonstrated a significant ibuprofen treatment effect (p < 0.05). Post-hoc analysis showed that ibuprofen-dependent reductions of both soluble Abeta and Abeta42 were most marked in entorhinal cortex (p < 0.05). Although interleukin-1beta and insoluble Abeta were more effectively reduced with longer treatment, the magnitude of the effect on soluble Abeta was not dependent on treatment duration.

Aging↗