PubMed Health⌕ Search

Biomedical subjects

J B Peiris

Publications and source records attributed to J B Peiris.

30 records · Page 2Linked to original sources
PubMed1980

Sodium valproate in trigeminal neuralgia.

Sodium valproate, which has been recently introduced for the treatment of epilepsy, was tried in 20 patients with trigeminal neuralgia. Six out of 20 patients had no attacks for six months to 18 months while, in three patients, the frequency and severity of attacks were reduced by at least 50%. Four patients responded well when sodium valproate was used in combination with other drugs. Six patients showed little or no response while one patient showed poor tolerance to sodium valproate.

Aged↗
PubMed1980

Giant aneurysms of the carotid system presenting as visual field defect.

Visual field loss was the presenting symptom in 19 patients with large intracranial aneurysms of the carotid system. Location of the aneurysm was cavernous, carotid-ophthalmic (two), supraclinoid (nine), anterior communicating (six). Other features were pain and a long history of fluctuating visual loss. Cavernous or carotid-ophthalmic aneurysms mostly caused purely uniocular field loss consistent with optic nerve compression. Supraclinoid aneurysms most often caused a lateral chiasmal syndrome. Anterior communicating aneurysms caused asymmetric compression of one or both optic nerves, the eye contralateral to the feeding artery being more often affected. Carotid ligation appeared to arrest visual deterioration in some patients in the supraclinoid group.

Adult↗
PubMed1978

Transient emboligenic aortoarteritis. Noteworthy new entity in young stroke patients.

The clinical and postmorten anatomical data in a group of ten patients with occlusive cerebrovascular disease in the 15- to 40-year group were studied. The occlusion of the peripheral supply artery in the brain in all cases was found to be due to thromboemboli generated from focal thrombotic lesions situated proximally in the aorta and elastic arterial trunks arising from it. These central thrombotic lesions were caused by a transient form of focal aortoarteritis that primarily affects medial elastic tissue underlying the thrombi. This is a new disease entity, distinct from Takayasu's and other forms of segmental aortitis. The pathogenesis of occlusive cerebrovascular disease in the young remains obscure in a majority of cases. In this context, the definition of this new entity is an important contribution to the understanding of nonatherogenic occlusive cerebrovascular disease.

Adolescent↗
PubMed1976

Clonazepam in the treatment of choreiform activity.

In a limited study, clonazepam, a new benzodiazepine derivative, has been found to be effective in suppressing choreiform movements in three patients with Huntington's chorea, three patients with non-familial chorea, and in one patient with senile chorea. In two patients with chorea of doubtful aetiology the response was not very satisfactory. A simple method was used to assess objectively the effect on choreiform movements. The effective dose varied from 3-5 to 5-5 mg a day. The drug was well tolerated by most of the patients.

Adult↗
PubMedDate not supplied

Immune activation during cerebellar dysfunction following Plasmodium falciparum malaria.

Evidence for immune activation was investigated in 12 patients with a rare syndrome of self-limiting, delayed onset cerebellar dysfunction following an attack of falciparum malaria which occurred 18-26 d previously. Concentrations of tumour necrosis factor, interleukin 6 and interleukin 2 were all significantly higher in serum samples of patients during cerebellar ataxia than in recovery sera and in the sera of 8 patients who did not develop delayed cerebellar dysfunction following an attack of falciparum malaria. Cytokine concentrations in the cerebrospinal fluid were also significantly higher in ataxic patients than in controls. These findings suggest that immunological mechanisms may play a role in delayed cerebellar dysfunction following falciparum malaria.

Adolescent↗
PubMedDate not supplied

Relationship between dose and serum concentrations of carbamazepine, phenytoin, phenobarbital, and primidone in a Sri Lankan population compared with a European population.

Concentrations of carbamazepine, phenytoin, phenobarbital, and primidone have been measured by high pressure liquid chromatography (HPLC) in serums of 177 Sri Lankan epileptic patients. Relationships between concentrations and dose per kg body weight of these drugs have been compared with those of patients in the Netherlands, using a matching procedure. Although variabilities in dose-concentration ratios were somewhat larger in Sri Lanka than in the Netherlands, no evidence was found of a systematic difference in pharmacokinetics between both populations.

Adolescent↗