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Biomedical subjects

J B Robbins

Publications and source records attributed to J B Robbins.

At least 217 records · Page 12Linked to original sources
PubMed1972

Enteric bacteria cross-reactive with Neisseria meningitidis groups A and C and Diplococcus pneumoniae types I and 3.

Enteric bacteria of 1,335 individual strains were studied for serological cross-reactions with Neisseria meningitidis groups A and C and Diplococcus pneumoniae types I and III. Enterobacterial antigens cross-reactive with the capsular polysaccharides of these four bacteria were found. Bacteria cross-reactive with noncapsular antigens of meningococci and pneumococci were also observed. Since some enteric bacteria possess antigens with serological specificities similar to those of meningococci, the possibility that enteric bacteria cross-reactive with meningococcal antigens provide an antigenic stimulus for the observed age-related "natural" immunity to this pathogen is discussed.

Animals↗
PubMed1971

Specific secondary biological properties of purified rabbit immunoglobulin M and immunoglobulin G antibodies to Brucella abortus and Bordetella pertussis.

Rabbit immunoglobulin (Ig)M and IgG antibodies to Brucella abortus and Bordetella pertussis were isolated as purified products and their specific secondary biological activities were compared. IgM antibodies were found to be more active than IgG proteins in inducing agglutination and sensitization of B. abortus for the complement-dependent bactericidal effect and in inhibiting B. pertussis-induced lymphocytosis in the mouse. IgM and IgG antibodies were found to be equally effective in inducing agglutination of B. pertussis suspended in a colloidal solution. These data parallel previous work to indicate that IgM antibodies to bacterial surface antigens are more efficient than IgG molecules in initiating biological processes concerned with the inactivation of these pathogens.

Animals↗
PubMed1971

Age-related susceptibility to Haemophilus influenzae type b disease in rabbits.

Anti-type b antibodies were detected in newborns and in most 6- to 8-week-old rabbits, similar to those observed in humans. Culture of the pharynx and rectum of rabbits at varied ages failed to yield Haemophilus influenzae type b. Bacteria with cross-reacting antigens were observed in both the pharyngeal and rectal cultures from rabbits of varied ages. Rabbits without preexisting serum anti-type b antibodies were highly susceptible to septicemia and death after injection of small numbers of H. influenzae type b. Passively acquired antibody, whether observed in newborns or injected into animals without preexisting antibodies, conferred a high degree of protection against H. influenzae type b.

Age Factors↗