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J B Ruit

Publications and source records attributed to J B Ruit.

4 recordsLinked to original sources
PubMed1990

Phase II study of lomustine, cytarabine, mitoxantrone, and prednisone (CAMP) combination chemotherapy for doxorubicin-resistant intermediate- and high-grade malignant non-Hodgkin's lymphoma.

A phase II study was conducted to evaluate the efficacy and toxicity of lomustine, cytarabine, mitoxantrone and prednisone (CAMP) chemotherapy in doxorubicin-resistant intermediate- and high-grade malignant non-Hodgkin's lymphomas (NHL). Among 30 patients, the complete remission rate was 27% (duration: 10, 16, 22, 35, 35+, 42+, 51+, 55+ months) and the partial remission rate was 20%. Median survival for complete responders was more than 4 years. The best responses were seen in patients with relapsed NHL compared to those with primary refractory NHL. Toxicity was mainly related to myelosuppression. The results suggest that the CAMP schedule can be applied on an outpatient basis with satisfactory efficacy in patients with relapsing intermediate- and high-grade malignant NHL.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1977

Reversal of sign of long spinal reflexes dependent on the phase of the step cycle in the high decerebrate cat.

Reversal of the sign of long ascending and descending spinal reflexes dependent on the phase of the step cycle has been shown in the high decerebrate cat. Electrical stimuli were applied to the skin over the dorsum of the metacarpals and metatarsals and the effects were recorded in the corresponding hindlimb or forelimb of the same side. Stimulation generally evoked an increase in activity of flexor or extensor muscles shortly before, and during, activity of the muscle. Inhibition of a muscle occurred when its activity overlapped with the activity of an antagonist muscle. From the latencies it was concluded that at least the early components of the long reflex responses are due to spinal mechanisms. In the stimulated limb the activity of flexor and extensor muscles was also modulated in a phase dependent manner. No consistent long spinal responses to skin stimulation were obtained in high spinal cats during stepping. Electrical stimulation of cutaneous nerve trunks in decerebrate preparations during stepping gave variable though phase dependent long spinal reflex effects.

Animals↗