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Biomedical subjects

J B Selkon

Publications and source records attributed to J B Selkon.

At least 19 recordsLinked to original sources
PubMed1979

The use of spore strips for monitoring the sterilization of bottled fluids.

A bacterial spore test has been developed which enables the efficacy of the sterilizing cycle recommended by the British Pharmaceutical Codex (1973) for bottled fluids to be accurately monitored. During a 14-month period this test detected faults in 3.3% of the sterilizing cycles, representing five distinct episodes of sterilization failure that passed unnoticed by the conventional controls of physical measurements and sterility testing. There were no failures of sterilization as detected by conventional techniques which were not indicated by the spore test.

Geobacillus stearothermophilus↗
PubMed1978

Abscesses of the frontal lobe of the brain secondary to covert dental sepsis.

The bacterial species found in pus aspirated from brain abscesses in two patients were typical of those found in dental sepsis. Subsequently apical-root abscesses were demonstrated in the upper jaws of both patients. This evidence strongly suggests that these cerebral abscesses were secondary to dental sepsis which could have spread from the teeth to the frontal lobes by several possible antaomical pathways.

Actinobacillus Infections↗
PubMed1978

A study of carbon dioxide-dependent strains of Streptococcus milleri.

Forty-four strains of non-haemolytic streptococci, from a variety of sites, that required CO2 for aerobic growth were identified as Streptococcus milleri. Of these strains, 40 (90%) possessed the Lancefield group-F antigen, the remainder being non-groupable with antisera to the group antigens A, C, F and G.

Aerobiosis↗
PubMed1977

Inhibition of phagocytosis in vitro by obligate anaerobes.

A variety of species of obligate anaerobes have been shown to interfere with the phagocytosis and killing of Proteus mirabilis and other aerobic bacteria in vitro. Although all the obligate anaerobes examined showed this activity, the effect was greatest with strains of Bacteroides melaninogenicus and B. fragilis. In contrast, none of the 36 aerobes tested acted in this way. These observations suggest that the presence of obligate anaerobes may be fundamental to the pathogenesis of some types of infections.

Bacteroides↗
PubMed1977

Metronidazole compared with penicillin in the treatment of acute dental infections.

The efficacy of metronidazole in the treatment of acute dental infections was investigated and compared with parenteral penicillin in a controlled trial. All 37 patients in the trial responded satisfactorily and metronidazole appeared to be as effective as parenteral penicillin. A further 24 patients treated with metronidazole also responded satisfactorily. Bacteriological studies of pus obtained from 25 patients revealed the presence of many species of obligate anaerobes. Since metronidazole is only active against obligate anaerobic bacteria it is concluded that these organisms are the important pathogens in acute dental infections.

Adult↗
PubMed1977

The API ZYM system in the identification of Gram-negative anaerobes.

The API ZYM reactions of type species of Gram-negative anaerobes representative of those encountered in human infections and of 56 clinical isolates of such organisms, identified by conventional techniques, were investigated. The API ZYM test clearly distinguished between the different genera and species examined and appears to provide a simple, reliable method for the identification of this group of organisms.

Bacteriological Techniques↗
PubMed1976

Cerebral abscess.

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Anaerobiosis↗
PubMed1976

Cost-effectiveness of two methods of screening for asymptomatic bacteriuria.

A comparison of two methods of screening schoolgirls for asymptomatic specimens of urine from 96.3, but that the home self-administered use of dipslides was successful in only 70.2%. The failure to obtain the return of satisfactory dipslides was most frequent in children under seven and over 11 years of age, and in children from the lower social classes; satisfactory dipslides were returned by 84% of children from social classes I, II, and III non-manual workers, but by only 58% of children from social class V and the unemployed. The cost per child screened was pounds 0.77 with the supervised method and pounds 0.26 with the dipslide method. An alternative supervised method which would have successfully screened 85% would have cost pound 0.55 per child screened. Using the home dipslide method, the cost per case of asymptomatic bacteriuria detected would vary from pounds 10.40 to pounds 20.00, depending on the age group screened.

Adolescent↗