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Biomedical subjects

J B Tingelstad

Publications and source records attributed to J B Tingelstad.

18 recordsLinked to original sources
PubMed1978

Lack of connection between the atria and the peripheral conduction system in a case of corrected transposition with congenital atrioventricular block.

This is the first documented histologic study of the heart of a patient with corrected transposition of the great vessels and congenital atrioventricular (A-V) block with no connection between the atria and an anterior type of peripheral conduction system. Musculature in the superior (anterior) walls of both atria was absent, as was the anterior A-V node. The peripheral conduction system began with the bundle of His. In place of the absent atrial musculature, fibrosis and calcification were present. The relation of laboratory evidence of connective tissue dyscrasia in the mother to the congenital A-V block in the child is discussed.

Adult↗
PubMed1977

Congenital heart block in newborns of mothers with connective tissue disease.

Of 22 children with congenital complete heart block (CCHB) available for study, 14 (63.6%) were born to 11 mothers with clinical or laboratory evidence of connective tissue disease, primarily lupus erythematosus (LE). Seven mothers had both clinical and laboratory evidence of disease while four had only positive laboratory studies including fluorescent antinuclear antibody, rheumatoid factor, and depressed complement levels. In adults with systemic LE, pathologic changes in the collagen surrounding the conduction system have led to the fibrosis and death from heart block. Antinuclear antibodies of the IgG class cross the placental barrier and newborn infants have been reported with transient skin lesions of lupus. Placental transmission of such antibodies may affect the fetal cardiac conduction system, surrounding collagen, and myocardium, leading in some cases to CCHB. This is probably one important etiologic factor in CCHB even though the mother is asymptomatic during her pregnancy.

Antibodies, Antinuclear↗
PubMed1976

Confirmation of a retrosternal mass by echocardiogram.

Case report of a 14 year old girl with Hodgkin's disease whose echocardiographic findings showed an anterior mediastinal mass between the right ventricle and the chest wall. The echocardiogram permitted an accurate measurement of the AP diameter of the mass. This technique, in conjunction with chest x ray, provides a means of determining changes in overall mass size as an indication of response to therapy.

Adolescent↗
PubMed1976

Fluttering of the interventricular septum. The result of truncal insufficiency.

We present a child with truncus arteriosus and truncal insufficiency who had diastolic fluttering of the anterior mitral valve leaflet and left ventricular surface of the interventricular septum on echocardiogram. Although the fluttering has been previously described in patients with aortic insufficiency, it has not been reported with truncus arteriosus.

Child↗