PubMed Health⌕ Search

Biomedical subjects

J B Turchik

Publications and source records attributed to J B Turchik.

4 recordsLinked to original sources
PubMed1980

Role of the central nervous system in acute-phase responses to leukocytic pyrogen.

Intracerebroventricular injection of rabbit leukocytic pyrogen (LP) into conscious, healthy cannulated rabbits produced markedly enhanced febrile and acute-phase responses as compared with equivalent-dose, single bolus intravenous injection. The increased effectiveness in inducing granulocytosis and hypoferremia on intracerebroventricular injection was matched by changing the method of administration of intravenous LP from a single initial bolus to multiple fractional doses over a 2-h period. This suggested that augmentation for these parameters may have reflected only a "reservoir" function of the cerebral ventricles which prevented rapid clearance of LP from the blood. The ability of LP to induce hepatic synthesis of haptoglobin and C-reactive protein was so markedly enhanced by intracerebroventricular injection, however, that a role of the central nervous system in mediating or in modifying in an important way a non-neural mechanism for this mediation must be postulated.

Animals↗
PubMed1975

Transient bacteremia associated with percutaneous liver biopsy.

Transient bacteremia associated with percutaneous liver biopsy was studied by pour-plate blood cultures, which were obtained immediately before and after the procedure and 5, 10, 15, and 30 min later in 89 patients. Part of the liver tissue was also cultured in all patients. Histological diagnoses included hepatitis, cirrhosis, cholangitis, fatty liver, granulomata, metastatic liver disease, lymphoma, and miscellaneous disorders. All blood cultures obtained before liver biopsy were sterile. Bacteremia was demonstrable in 12 patients (13.48%). In most of these patients, blood cultures were positive for as long as 15 min after liver biopsy; all cultures were negative at 30 min. Among the bacteria associated with 12 episodes of bacteremia were Escherichia coli, Klebsiella, Bacteroides, enterococci, diphtheroids, Staphylococcus aureus, alpha-hemolytic Streptococcus, and Streptococcus pneumoniae. The patients with positive liver biopsies had a higher incidence of bacteremia (83.3%) than did the patients whose liver biopsies were sterile (8.r%); this difference is stastically significant (P smaller than 0.01). Thus, liver biopsy can be associated with transient bactermia.

Bacteroides↗