PubMed Health⌕ Search

Biomedical subjects

J Bódis

Publications and source records attributed to J Bódis.

At least 55 records · Page 3Linked to original sources
PubMed1992

Effect of LHRH and its analogues on the progesterone secretion of human granulosa cells in vitro.

Progesterone secretion of cultured human granulosa cells treated with LHRH or its analogues was measured. Granulosa cells were also stimulated with LH, FSH, cAMP or forskolin. No differences could be observed in the progesterone basal secretion of cultures treated with or without LHRH or its analogues and after the various stimulations. It was concluded that the clinical experience that the sensitivity of ovaries for gonadotropins after LHRH desensitization is decreased could not be explained with the peripheral effects of LHRH on the granulosa cells. From the data obtained, the lack of LHRH receptors in the ovaries are suggested in humans.

Female↗
PubMed1991

[Prospective hemorheological study in the third pregnancy trimester].

The prospective hemorheological study was performed in the third trimester of pregnancy. Whole blood viscosity, haematocrit, plasma viscosity and haemoglobin were measured. They did not find significant changes of these parameters in healthy pregnancy. The rheological parameters in the macrosomic group (75%) were same than in the normal group at 37th weeks, but later were significantly higher. Higher blood viscosity has been found in those pregnant women, who delivered retarded fetuses. They suggest, that the progressively increasing blood viscosity in the third trimester of pregnancy causes the disturbances in the intervillous microcirculation, and produces intrauterine growth retardation.

Blood Viscosity↗
PubMed1991

[Analysis of noradrenaline, dopamine and serotonin levels in follicular fluid following superovulatory treatment].

The authors measured the noradrenaline (NA), serotonin (5-HT) and dopamine (DA) content of 47 normally maturated and 16 cystically degenerated follicular fluid samples obtained from patients involved in the in vitro fertilisation and gamete transfer program. The patients were given human menopausal gonadotropin (HMG) as a superovulation treatment, and they were given 7500 IE human Chorionic Gonadotropin (HCG) to induce ovulation 34-36 hours prior to the follicular puncture done by laparoscope. The NA content of the normally developed preovular follicles is 11.4 +/- 8.4 micrograms/100 ml on average. For the cystically degenerated follicles the data are following: 1.1 +/- 0.7 micrograms/100 ml (p less than 0.001). 5--HT and DA for the preovulatory follicles are 14.3 +/- 8.9 micrograms/100 ml and 19.3 +/- 8.2 micrograms/100 ml respectively; at the same time for the cystically degenerated follicles they are 12.2 +/- 6.2 micrograms/100 ml, and 12.7 +/- 6.8 micrograms/100 ml respectively. They presume that the higher amount of NA in the follicular fluid might play an important role in the mechanisms of ovulation, the regulation of postovulatory tubal motility, and the release of progesterone from granulosa cells.

Adolescent↗
PubMed1991

Neonatal effects of methyldopa therapy in pregnancy hypertension.

This study has been performed to assess the effect of methyldopa (MD) therapy in pregnancy hypertension on the neonatal adaptation. Infants born to mothers on MD for several weeks prior to delivery and presenting with excessive tremor and irritability were evaluated according to the dose of maternal MD. Pregnancy hypertension and high dose MD was associated with impaired placental perfusion, compromised function of fetoplacental unit and more frequent surgical delivery. Infants of mothers on high (1.25-2.0 g/day) or low (less than 1 g/day) MD had gestational age, head circumference, acid-base balance, Apgar score and blood pressure similar to those born to healthy control mothers. The birth weight of infants of the high MD group, however, were significantly lower than in the low-dose or control groups. MD therapy resulted in a dose-dependent increase in plasma levels of prolactin, thyrotropin and triiodthyronine indicating decreased dopaminergic inhibition of pituitary hormone release. Plasma thyroxine concentration, however, decreased significantly. Cerebrospinal fluid noradrenaline was found to be markedly depressed after maternal MD showing disturbed central nervous system monoamine metabolism. It is suggested that MD administration to mothers presenting with pregnancy hypertension interferes with cerebral monoamine metabolism of the neonate and induces alterations in some endocrine functions under dopaminergic control. The possible role of chronic fetal distress frequently associated with pregnancy hypertension should also be considered.

Adaptation, Physiological↗
PubMed1986

Plasma prolactin levels in full-term newborn infants with idiopathic edema: response to furosemide.

In an attempt to explore the possible role of prolactin (PRL) in the control of neonatal electrolyte homeostasis, this study has been carried out to compare plasma electrolyte concentrations, urine volume and urinary electrolyte excretion as well as plasma PRL levels in healthy full-term neonates with idiopathic edema prior to and after furosemide treatment. No differences in plasma sodium and potassium were demonstrated, edematous neonates, however, had less urine volume and sodium excretion than neonates without edema. Plasma PRL proved to be significantly higher in the edematous group (11.0 +/- 1.9 vs. 4.2 +/- 3.1 U/l, p less than 0.01) but it remained unaltered by furosemide challenge (8.5 +/- 1.5 U/l) in spite of the marked elevation of urine flow and sodium excretion. It is concluded that PRL may be involved in the control of the volume and composition of the body fluids in the neonate but further studies are needed to define the effect of changes in body composition on the neonatal PRL secretion.

Diuresis↗
PubMed1985

Application of the parametric scan in the investigation of uteroplacental blood flow.

We developed a new radioisotope technique to measure placental blood flow for the early detection of placental insufficiency. Using the parametric scan, placental perfusion was measured in 80 late-pregnant women. The T-maximum pictures obtained made it possible to differentiate between the vascular and intervillous phases of placental blood flow. The time period of intervillous phase calculated as the percentage of the whole placental Tmax was given as the intervillous perfusion index (IPI). It was demonstrated that the IPI was significantly higher in pregnancies complicated with intrauterine growth retardation (64.2% +/- 16.5%), hypertension (60.0 +/- 15.2) and oedema (57.9% +/- 10.1%) than in the control group (33.7% +/- 10.5%). These data suggest that the first sign of placental insufficiency is the prolongation of the IPI which is likely to precede the quantitative reduction of placental perfusion.

Female↗
PubMed1985

Effect of low-dose dopamine infusion on prolactin and thyrotropin secretion in preterm infants with hyaline membrane disease.

The effect of low-dose (2-4 micrograms/kg/min) and long-term (greater than or equal to 46 h) dopamine infusion on serum prolactin and thyrotropin concentrations was investigated in 8 preterm infants with hyaline membrane disease. Dopamine was administered for systemic hypotension and/or for impending renal failure. Serum prolactin decreased from 1,314.5 +/- 422.7 microU/ml to 489.9 +/- 464.1 microU/ml (p less than 0.005), while serum thyrotropin fell from 3.77 +/- 2.27 microU/ml to 1.01 +/- 0.25 microU/ml (p less than 0.025) during dopamine infusion. Our data indicate that exogenous dopamine exerts an inhibitory effect on the secretion of prolactin and thyrotropin even in the sick preterm neonate. The role of prolactin in fetal lung maturation and in regulation of the neonatal tissue water stores is discussed. The results of the present study are also useful in explaining the renal effects of long-term low-dose dopamine infusion in the sick preterm infant.

Dopamine↗
PubMed1985

Determination of the intervillous perfusion index in pregnancies with intrauterine growth retardation.

The authors developed a new radioisotope technique to measure placental blood flow for early detection of placental insufficiency. Using this method placental perfusion has been measured in 20 healthy pregnant women and in 15 pregnancies complicated with intrauterine growth retardation (IUGR). The T-maximum pictures obtained made it possible to differentiate between the vascular and intervillous phases of placental blood flow. The time period of intervillous phase calculated as the percent of the whole placental T-maximum was given as the intervillous perfusion index (IPI). It has been demonstrated that IPI is significantly longer in IUGR pregnancies (67.0 +/- 14.6) than in the control group (31.6 +/- 10.7). These data suggest that the first sign of placental insufficiency is the prolongation of IPI, which is likely to precede the quantitative reduction of placental perfusion.

Adult↗
PubMed1985

The influence of NaCl supplementation on the postnatal development of urinary excretion of noradrenaline, dopamine, and serotonin in premature infants.

The present study was designed to investigate the role of noradrenaline (NA), dopamine (DA), and serotonin (5-HT) in the adaptation of premature infants to alterations of sodium balance. Urinary excretion of NA, DA, and 5-HT was measured spectrofluorimetrically in a group of low birth weight premature infants with (group S) and without (group NS) NaCl supplementation. Group NS consisted of 10 infants with a birth weight of 1200-1750 g (mean, 1493 g) and gestational age of 28-31 wk (mean, 30.1 wk). Group S included 10 infants with mean birth weight of 1414 g (range, 1150-1600 g) and mean gestational age of 30.5 wk (range, 27-32 wk). Measurements were made on the 7th day and weekly thereafter until the 5th wk of life. NaCl supplementation was given in a dose of 3-5 and 1.5-2.5 mEq/kg/day for 8-21 and 22-35 days, respectively. In group NS, mean urinary excretion of NA and DA increased from 8.6 +/- 1.5 and 15.8 +/- 2.4 micrograms/day to maximum values of 21.4 +/- 5.5 (p less than 0.05) and 33.4 +/- 6.0 micrograms/day (p less than 0.01) in weeks 2-3, respectively. 5-HT excretion averaged about 60 micrograms/day and showed no consistent change during the course of the study. NaCl supplementation prevented the rise of NA and DA excretion above the initial baseline values. The postnatal course of 5-HT excretion, however, remained unaffected by NaCl supplementation. Urinary excretion of NA in weeks 2-3 (p less than 0.05) and DA in weeks 2-4 (p less than 0.05) were significantly lower in group NS.

Dopamine↗
PubMed1985

The effect of metoclopramide administration on electrolyte status and activity of renin-angiotensin-aldosterone system in premature infants.

The present study has been carried out to define whether endogenous dopamine contributes to the regulation of renal sodium handling and the function of the renin-angiotensin-aldosterone system in low birth weight premature infants. Twelve premature infants with mean birth weight of 1420 g and mean gestational age of 29.2 wk were given metoclopramide (MTC) in a dose of 0.1 mg/kg/day to treat delayed gastric emptying, regurgitation, and abdominal distension at the age of 17-23 days. Infants were kept on either a low (2-3 mEq/kg/day) or high (4-7 mEq/kg/day) sodium diet to modulate activity of RAAS. Prior to and after a 3-day period of MTC administration, blood samples were taken, and in six male infants 24-h urine collections were made to determine plasma and urine electrolytes, plasma renin activity, plasma aldosterone concentration, and urinary aldosterone excretion. We demonstrated that plasma sodium and potassium concentrations and plasma renin activity were not altered by MTC. On the other hand, in response to MTC, there was a significant increase in urinary sodium excretion (1.8 +/- 0.3 versus 2.3 +/- 0.3 mEq/kg/day) and a decrease in potassium excretion (1.2 +/- 0.2 versus 0.8 +/- 0.1 mEq/kg/day); plasma aldosterone concentration and urinary aldosterone excretion decreased significantly from initial values of 2101 +/- 274 pg/ml and 2.91 +/- 0.52 micrograms/day to 1500 +/- 207 pg/ml (p less than 0.01) and 2.21 +/- 0.43 micrograms/day (p less than 0.01), respectively, after MTC. These alterations were independent of the pretreatment hormone levels.(ABSTRACT TRUNCATED AT 250 WORDS)

Aldosterone↗
PubMed1984

Noradrenaline content of cerebrospinal fluid in preterm and term infants recovering from perinatal asphyxia.

Noradrenaline content was measured in the cerebrospinal fluid of 17 full-term and 16 premature newborns with or without perinatal asphyxia. Upon the effect of asphyxia the noradrenaline content of cerebrospinal fluid exhibited a more than three-fold increase (from 2.61 +/- 1.45 microgram/l to 10.86 +/- 4.02 micrograms/l) in mature newborns, but it decreased to about half of the control value in premature babies (from 2.39 +/- 0.72 microgram/l to 1.25 +/- 0.70 microgram/l). The observations emphasize the role of central noradrenergic structures in the organization of asphyxia-induced stress-response and in the regulation of adaptation to extrauterine life.

Asphyxia Neonatorum↗
PubMed1982

[The effect of glucocorticoid treatment during pregnancy on adrenal function in newborn rats (author's transl)].

The authors examined the effect of prednisolone-salium succinate administered on the 17th or 18th day of pregnancy on the adrenal function of newborn rats. They found that in doses of 1.0 or 2.0 mg/kg it does not affect physiological development or, respectively, the extent of the circadian rhythm or the stress response. However, the adrenal function of newborn animals was significantly inhibited by 30.0 mg/kg as regards its adaptability to extra-uterine life. The authors point out the importance of investigations to determine the adrenal function of newborns following steroid therapy to prevent RDS.

Adrenal Glands↗
PubMed1982

[The effects of glucocorticoid treatment during pregnancy on lecithin synthesis in the fetal rat lung (author's transl)].

In the course of investigations in pregnant rats the authors established that the effect of prednisolone-sodium succinate on the maturation of the fetal lung depends on the dose administered and/or on the time at which it was given. The prednisolone only increased the surface-active lecithin concentration - thus accelerating the functional maturation of the lung - if it was given on the 17th or 18th day of gestation, in a dose of 1.0 mg/kg or 2.0 mg/kg. A dose of 0.5 mg/kg had no effect, while a high dose not only inhibited lecithin synthesis but also caused significant side-effects. The authors point out that the glucocorticoids only have a favorable effect on lung maturation if administered during a certain period in their development, and link this to the maturation process of the specific cortisol receptors in the lung. They also point out the potential danger of glucocorticoids administered to prevent dyspnea and emphasize the importance of determining the lowest effective dose of the various synthetic preparations and/or the optimum time for giving them. They raise the question of whether there is also an ideal time for glucocorticoid treatment in human pregnancies.

Animals↗