Biomedical subjects

J Bönhof

Publications and source records attributed to J Bönhof.

4 recordsLinked to original sources

PubMed1998

[Noninvasive determination of coronary flow reserve with signal enhanced high resolution transthoracic Doppler color echocardiography].

UNLABELLED: The feasibility of non-invasive assessment of coronary flow reserve (CFR) in the left anterior descending artery (LAD) using echo-enhanced high-resolution transthoracic color Doppler echocardiography (TTCD) was investigated. The results were compared with the degree of coronary diameter-stenosis obtained during cardiac catheterization. CFR has proven to be useful in the selection of patients undergoing invasive treatment of coronary artery disease and in estimating their prognosis. However, CFR could only be determined in everyday practice invasively during catheterization procedures. Recent development of high-resolution TTCD allows transthoracic visualization of distal LAD and supra-apical intramyocardial perforator branches, and non-invasive measurement of CFR. CFR was determined by measuring the ratio of pulsed-wave Doppler time velocity integral during adenosine-induced hyperemia (140 micrograms/kg/min i.v.) to baseline value. If Doppler signal of LAD flow was insufficiently at basal condition, an echo enhancer (Levovist) was used. 45 patients were examined by TTCD (7 MHz B-mode, 5 MHz color Doppler, 3.5 MHz PW Doppler) after coronary angiography had been performed. Group I consisted of 15 patients without heart disease, Group II of 15 patients with 40 to 70% isolated LAD diameter stenosis, and Group III of 15 patients with > 70% LAD diameter stenosis. Peripheral LAD coronary flow at baseline condition was assessed in 40 patients (88%) using TTCD. CFR could be quantified in 36/45 patients (80%), in 18 patients without echo enhancer, and in 18 patients with echo-enhancing agent. In 9/45 patients CFR could not be assessed. CFR in Group I was 3.13 +/- 0.57, in Group II 2.23 +/- 0.20 (vs Group I p < 0.01) and in Group III 1.64 +/- 0.30 (vs Group II p < 0.02). CONCLUSION: CFR of LAD can be determined in 80% of patients by the synergistic use of high-resolution TTCD combined with intravenous given ultrasound echo-enhancing agent.

Adult↗

PubMed1990

[Echogenic splenic lesions--incidence and differential diagnosis].

In order to estimate the incidence and clinical relevance of echogenic focal lesions in the spleen, 121,372 ultrasound investigations from seven laboratories were evaluated. Ninety-two cases with echogenic lesions in the spleen were reviewed (incidence: 3.2 to 14.2 of 10,000 patients). Differential diagnosis included neoplastic tumors (17.4%; five metastases, three lymphomas, seven hemangiomas, one lymphangiomatosis), vascular disorders (17.4%: bleeding, infarct) and inflammatory focal lesions (8.7%; abscess, calcifications). Follow-up studies showed no change in size and pattern in a further 17.4% of the lesions, indicating benign disorders. Thirty patients suffered from a malignant condition with splenic metastasis or lymphomas in eight cases. In a further five patients, it was possible to confirm echogenic hemangiomas. There are no specific echographic patterns which differentiate hemangiomas from malignant tumors.

Diagnosis, Differential↗

PubMed1985

[Qualification and quality control in sonography].

On the basis of guidelines issued by the Kassenärztliche Vereingung Hessen, some criteria for the application of sonographic examinations are presented. Minimal requirements for sonographic equipment in certain specialties are mentioned, and it is pointed out how not only case history and clinical examination but also one's own sonographic evidence are important for a accurate sonographic diagnosis.

Abdomen↗

PubMed1978

[Changes in erythrocyte shape and volume caused by silymarin].

In vitro treatment of fresh human red cells with silymarin as well as its individual components silybin and silydianin (10(-4) and 10(-3) g/ml of water-soluble sodium or hemisuccinate sodium salt) resulted in disc-crenated sphere transformation of the erythrocyte shape, silydianin being least effective. 10(-4) g/ml of each compound tested, causing only slight changes of the shape of the erythrocytes, significantly increased their maximum diameter, whereas 10(-3) g/ml silymarin or silybin, resulting in a marked sphering of the cells, significantly decreased their maximum diameter. Mean cell volume in isotonic medium determined by Coulter counter method was significantly increased by 10(-3) g/ml silymarin, silybin, silydianin and, above all, chlorpromazin. 2 x 10(-5) g/ml chlorpromazine significantly increased the critical haemolytic volume in hypotonic medium, determined by microhaematocrit method, whereas an insignificant increase of the critical haemolytic volume was induced by 2.7 x 10(-4) g/ml silymarin.

Chlorpromazine↗