PubMed HealthSearch

Biomedical subjects

J Böning

Publications and source records attributed to J Böning.

14 recordsLinked to original sources

Disorders of smooth pursuit eye movement and auditory N100 in schizophrenic patients.

Attentional factors are thought to affect eye-tracking patterns. The present study examined the hypothesis that specific quantitative features of eye tracking would be correlated with the amplitude of a component of the auditory evoked potential, the N100, which is known to be enhanced by arousal and selective attention. We studied 12 clinically stable schizophrenic patients by means of DC-electro-oculography. The frequency and amplitude of different types of saccades (catchup, backup, anticipatory saccades, and square wave jerks) were assessed. The results suggest that small and large saccades, as classified by a simple amplitude criterion (4 degrees), have differential meanings and indicate that enhanced amplitudes of small saccades are an effect of arousal.

Adult

Syndrome metamorphoses in anorexia nervosa--an example of integrative psychopathology.

In connection with the current knowledge of interdisciplinary results of research, we discuss clinical syndrome transitions of psychotic and non-psychotic quality in the course of anorexia nervosa. According to its internal and external conditions, anorexia nervosa can in principle occur in any person and in any phase of life during a critical trial situation as an ontologically given possibility of specific psychosomatic reaction. In the course of a mainly neurobiologically determined protopathic change of psychologically initiated cross-sectional psychopathology, very heterogenous secondary syndromes (impulsive, phobic, obsessive-compulsive, addictive, autoaggressive, depressive and schizophreniform) may facultatively become manifest. The similarity of such anorexia nervosa metamorphoses with classical nosological disease entities is likely to be based on a common disturbance of biological feedback systems. As a touchstone of classical 'intermediate area' in psychiatry the changing clinical picture of anorexia nervosa provokes a unitarian view of mental disease. It exemplifies a hesitant change of paradigm in an up till now dualistic conception of organic/biological and psychological models. This complementary approach tries to integrate psychic phenomena into a holistic understanding of complex psychopathological realities on the basis of qualitative and dimensional aspects in order to counteract the nowadays threatening loss of information in psychiatric phenomenology.

Anorexia Nervosa

["Modality shift" paradigms and subjective basic symptoms in schizophrenic patients with various developmental biological risk anamnesis].

Clinical experimental research on schizophrenia does not consider maturation processes of brain function in the majority of cases. In the course of neuronal organization and the differentiation phases of cerebral systems, early traumas in functionally important regions of the brain are accompanied by a facultative impairment of complex systems of information processing. Against the background of the comprehensively coherent "integrative psychobiological model of schizophrenia" (Ciompi) with high construct validity, (experimental) psychology investigations are reported on in the context of the "high-risk" concept in 44 young (20-37 years old) and mainly chronic schizophrenic patients with formation of a specific hypothesis for the developmental biology of the condition. In two homogeneous groups with the same structure, it is checked whether a discriminative appraisal concerning a different organization principle of central information processing systems is possible with "crossmodal" choice-reaction times (cCRT) and certain subscales of the Frankfurt symptom questionnaire (FBF) with regard to alternatively distributed and specially operationalized anamnestic biological risk factors. It can be objectively established in terms of experimental psychology that postpsychotically de-actualized "risk-free" schizophrenics differ from the reference group with a high-risk anamnesis in terms of significantly prolonged cCRT, but not from healthy subjects and an "MBD" control group. In addition, the FBF subscores "weakness of selective attention" and "loss of automatized skills" correlate with poor cCRT.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult

[Performance-psychologic cross-sectional study of young schizophrenic patients with a subchronic and chronic disease course].

According to ICD-9 and DSM-III-R-criteria 14 subchronic schizophrenic male patients (duration of illness less than 2 years) and 17 chronically ill male schizophrenics (duration of illness between 5 to 12 years) matched for sex, age, education, type of illness, and medication were with the aid of 4 tests investigated with respect to time characteristics of performance parameters. Whereas subchronic patients revealed performance scores within the normal range of reference scores, chronically ill patients showed dissociative variations in performance (high scores in reasoning, low scores in speed factor). This can be interpreted as instability of brain functioning which characterizes schizophrenics suffering from a long duration of illness. Correlations between prolonged reactions to "crossmodal" choices and subjective basic symptoms in subchronic patients are hints at well established introspection ability of self regarded complaints.

Adult

[Immunologic diagnostic of blood CSF barrier in the course of delirium tremens (author's transl)].

Fifty chronic alcoholics with acute withdrawal (in the state of delirium tremens) were examined initially and in the following weeks by quantitatively testing immunoglobulins in the serum and in the cerebrospinal fluid to study the dynamics of the blood-CSF barrier. Compared -to other persons of the same age, acutely delirious patients show a pathologic IgG-IgA constellation in the CSF which does not depend on the serum. That points to an infrastructural barrier function disorder. After 2--4 weeks, delirium tremens, normally in the process of recovering, shows distinct sanitation of the immunologic spectrum of the CSF. With regard to their dynamic proceedings, the results confirm other findings on brain metabolism, biochemistry, neurophysiology, and pathologic anatomy during delirium tremens. The totally and progressively disturbed blood-CSF barrier system of complicated cases of delirium tremens (e.g., Korsakov's and Wernicke's syndromes) seems to provide the possibility of deterioration of the clinical syndrome. The method, simple to implement in the laboratory, permits not only an overall evaluation of the dynamic blood-CSF barrier function in acute and postdelirious state, but also provides both the possibility to diagnose a persistent infrastructural residual syndrome and to indicate a pathophysiologic complication of the clinical course.

Adult

[Clinical side and adverse effects of antidepressant drugs (author's transl)].

Cases of extrapyramidal-motoric and psychologic side effects are reported when treatment with antidepressant drugs was performed. They have not been mentioned in the literature before. Hypokinetic disorders of speech and motion, tonic-atonic disturbances, dyskinesia and myoclonic muscle contractions are listed. Besides the latter movement disorders, "dreamy state", episodic amnesia ("ictal" amnesia) and amnestic "black out" as transient memory disorders have been observed.

Adult

[Anorexic syndrome and depression. Considerations from a case history].

A connection between anorexic syndrome and depression has been the object of psychoanalytic as well as psychiatric considerations for a long time now. We report the case of a 45-year-old woman suffering from anorexia nervosa and depression. Biographically-anamnestic aspects are shown in connection with depth-psychological and psychiatric ones, thus trying to achieve a synopsis.

Anorexia Nervosa

[Psychosomatic and psychopathological aspects in dental-orofacial medicine with special reference to old age].

The mouth is frequently affected by psychosomatic manifestations and communicative intimacy. Together with the age-related changes to central nervous system and organic changes in the chewing mechanism and oropharynx, these changes represent a failure of psychodynamic coping. With advanced age a "tempora minoris resistentiae" associates with a "locus minoris resistentiae". This etiopathogenetic constellation triggers psychosomatic conversion phenomena and "circumscribed" hypochondrias, as well as dysmorphobobic delusional developments, and hypochondric cyclothymic depressions. When there is an organic, nerval accentuation of these changes the symptoms often became chronic. It must be pointed out that a mimic disease often resembles a monosymptomatic masked depression, frequently resulting in false diagnosis. Contextual to anthropologic-psychologic dimensions of pain sensation, this work finally deals with the psychophysiologic complementary model of orofacial pain-dysfunction syndrome.

Aged