Ginger, the common spice, has recently been found to act as a potent inhibitor of thromboxane synthetase, raising levels of prostacyclin, without a concomitant rise in PGE2 or PGF2 alpha. Indications for use of ginger to replace either thromboxane inhibitors having serious side effects or prostacyclin are given.

Condiments↗

PubMed1986

Carbon dioxide inhalation therapy for anxiety: effectiveness due to increased prostacyclin and decreased thromboxane biosynthesis? Re-evaluation of a neglected technique.

CO2 inhalation has been used for many years in the treatment of various psychiatric and medical disorders and different rationales for its effect have been offered. Since it has been recently found that CO2 inhibits thromboxane biosynthesis and raises levels of prostacyclin, a new rationale for the effect of CO2 inhalation, based on its inhibition of thromboxane biosynthesis, is offered.

Anxiety↗

PubMed1986

Increased serum copper in pulmonary hypertension: involvement of thromboxane?

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Copper↗

PubMed1986

Loop diuretics causing reduction of voluntary alcohol drinking: relevance of thromboxane inhibition and opiate receptor activation?

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Alcohol Drinking↗

PubMed1985

Lithium-induced improvement of myotonia: relevance of prostaglandin E1 blockade by lithium.

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Humans↗

PubMed1984

Prolonged breast feeding as a prophylaxis for recurrent otitis media: relevance of prostaglandins.

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Alprostadil↗

PubMed1984

How information processing mode could affect prostaglandin E1 metabolism and lung inactivation: relevance of hemispheric specialization, neurotransmitter asymmetry and brain reactivity.

Due to asymmetry of brain neurotransmitters and differential hemispheric information processing modes, it is suggested that the excessive use of one information processing mode could engender a state of brain reactivity whose neurochemical correlates would be either a rise in melatonin or beta-endorphin in systemic circulation. Since melatonin and beta-endorphin have opposite effects on lung-mediated regulation of prostaglandins, it is further suggested that the pulmonary inactivation of prostaglandin E1 would either be increased or inhibited. Low levels of PGE1 would engender high levels of PGE2 whose effects would explain the findings in schizophrenics of: 'reducing' pattern of visual evoked response, cerebral atrophy, and viral and autoimmune phenomena. The primacy of the disordered cognitive style in leading up to the immunological, biochemical and neuropathological processes is stressed. Implications of this model for understanding depression, anxiety and phobic disorders, autism, attention deficit disorder, obesity, alcoholism, smoking, drug addiction, sexual deviations, and certain psychosomatic and psychophysiological disorders are suggested.

Alprostadil↗

PubMed1984