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Biomedical subjects

J Baillet

Publications and source records attributed to J Baillet.

At least 37 records · Page 2Linked to original sources
PubMed1985

[Efficacy of ranitidine and cimetidine in the treatment of gastric or duodenal ulcer resistant to an initial treatment with cimetidine. Multicenter controlled therapeutic trial].

In a controlled clinical trial conducted in 28 centers, 354 ambulatory patients with a cimetidine-resistant duodenal or gastric ulcer (at least six weeks of treatment at a dose of 1 g/day) confirmed by endoscopy were allocated at random to either ranitidine or cimetidine treatment: 166 patients received cimetidine (1.6 g/day in 4 oral doses), and 188, ranitidine (0.3 g/day in 2 oral doses). The two groups differed significantly with regard to sex and history of gastrointestinal hemorrhage but not with regard to age, weight, history of peptic disease, history of perforated ulcer, duodenal/gastric ulcer ratio, number of smokers and alcohol consumers. The criterion of effectiveness was endoscopic healing of the ulcer after six weeks of treatment; in case of doubt, vital staining with methyl blue was performed. A significant difference was observed between the results of the two treatments in the duodenal group (p less than 0.05) but not in the gastric group, the healing rates being respectively 71 p. 100 and 65 p. 100 with ranitidine, and 59 p. 100 and 44 p. 100 with cimetidine. Twelve patients developed side-effects with a highly significant difference between the two groups: 11 patients under cimetidine and one patient under ranitidine (p less than 0.001). These results show the effectiveness of ranitidine as a complementary treatment in cimetidine-resistant peptic ulcers of duodenal location.

Adult↗
PubMed1983

[Dynamic study of the diffusion and clearance of proteins in human interstitial tissue].

The application of a venous tourniquet leads to distension of the distal venous and capillary circulation and a local increase in plasma volume. In the normal subject, plasma volume returns to its initial level within approximately 10 sec of tourniquet release. In subjects affected by cyclical oedema, the local increase in plasma volume persists several minutes after tournique release. Radioactive labelling of plasma proteins shows that this delay is associated with the retention of plasma proteins by the tissues. These proteins are subsequently cleared by lymphatic drainage or diffusion back into veins. These results suggest that the combination of tournique test with the labelling of plasma proteins measures capillary and venous permeability as well as tissue protein clearance kinetics.

Body Fluid Compartments↗
PubMed1982

[Is there any justification to the scintigraphy and echotomography B association for the tracking down of hepatic metastases? (author's transl)].

Regarding the tracking down of hepatic metastases, a study was made on 58 patients presenting either digestive or genital adenocarcinoma. The determining criterion of selection was the carrying out of the three following tests within the same month (Technetium 99 Scintigraphy, Echotomography B and surgery). The global breakdown of exact answers is in favour of echography (72% against 53%), echography being more reliable than scintigraphy. Therefore echotomography B seems to be the first morphological method that should be proposed; and for improving the tracking down, scintigraphy makes the interpretation of the results more difficult, and reduces the number of correct answers.

Humans↗
PubMed1982

[Pulmonary embolism. Perfusion and ventilation pulmonary scintigraphy findings (author's transl)[].

After discussing the rather particular misadventures that the concept, diagnosis, and treatment of pulmonary embolism have been subjected to in France, the techniques for performing and analyzing results of pulmonary scintigraphy are described. Typical findings are one (or more) totally excluded areas in the biopsy specimen, easily systematized on a profile film. Though scintigraphy imaging appears to be essential, the sensitivity of the technique enabling positive exclusion of a pulmonary embolus if the image is normal, it is not specific. Results of the investigation appear to vary according to the use of a "soft approach" (repeated scintigraphy, heparinization) or a "hard approach" (pulmonary angiography, venography, fibrinolytic). Practical experience tends to show, however, that fallacies appear mainly when an attempt is made to elucidate cases other than acute emergencies, as for example in patients with lung cancer, women on the contraceptive pill, and chronic bronchopathy patients. It is strongly recommended that clinical studies be conducted to compare the "soft" and "hard" approaches, in order to obtain a consensus of opinion on the diagnosis and treatment of pulmonary embolism, a subject which remains passionate. . . and passional.

Angiography↗
PubMed1981

[Changes in serum beta-thromboglobulin levels during oral contraception, cardiac valve disease and pulmonary embolism (author's transl)].

beta-thromboglobulin (beta TG), a platelet-specific protein, was measured in the plasma of 53 healthy subjects (20 men and 33 women), 53 women using estrogen-progestogen contraceptives, 31 patients with cardiac valve disease (including 19 with prosthesis) and 71 patients about to undergo scintigraphy for suspected pulmonary embolism. Compared with levels in healthy subjects, beta TG levels were significantly increased in oral contraceptive users and in cardiac patients with or without prosthesis. High beta TG levels were also found in 20 out of 28 patients with pulmonary embolism confirmed by scintigraphy, but also in some of the .9 lung patients with chronic bronchopulmonary disease. Cardiac patients treated with heparin had higher beta TG levels than non heparin-treated patients, which raises queries about a possible influence of heparin on this particular blood protein.

Adult↗
PubMed1981

[Effectiveness of various hormonal preparations in adults with hypothyroidism (author's transl)].

Among more than 7000 adult patients with suspected dysthyroidism in who radioimmune assays were performed, the authors have selected 21 patients with high TSH hypothyroidism who had assays before and after replacement therapy with various preparations prescribed by their G.P. The results in this group of 61 treatments of at least 3 weeks duration were as follows: (1) under thyroid extract or thyroglobulin (21 treatments), the condition persisted in the majority of patients; (2) under thyroxine (31 treatments), the thyroid function returned to normal with a once-a-day dose of 150 mcg/-T4; (3) under triiodothyronine (7 treatments), none of the patients reverted to euthyroidism. Levothyroxine therapy therefore appears to be the most effective and cheapest way of providing optimal replacement therapy in patients with hypothyroidism. The daily dose of about 150 mcg can easily be adjusted according to the results of occasional hormonal assays.

Humans↗
PubMed1979

Idiopathic edema.

Explore the source record for details and available documents.

Diagnosis, Differential↗
PubMed1979

[Study of muscle hemodynamics during exercise: Physiological and pathological variations in Xe 133 elimination: A new method of interpretation (author's transl)].

Muscle blood flow measurements are of physiological (and pathological) significance only during effort. For this reason, the authors used Xe 133, which has been known since 1964, to measure regional muscle blood flow after its injection into the muscle, to quantify results during effort (pedalling). Effort is controlled by two measurable parameters: the weight lifted by the pedal and the frequency of movements. Curves showing the reduction in intramuscular Xe 133 levels cannot be mathematically formulated. It is easy, however, to measure their areas and thus define a mean elimination time (Tm) between times T1 and T2, beginning and end of effort, corresponding to activities A1 and A2 such that: formula: (see text). Normal Tm value, measured in 58 normal subjects with variable frequencies and weights lifted is: Tm = 1.70 +/- 0.38 min. The values in 70 patients with arteritis were significantly longer and can be greater than 3.5 min. This objective test could be of value in quintifying the effects of so-called vasodilators, both in patients with arteritis and venous insufficiency.

Humans↗