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Biomedical subjects

J Barberá

Publications and source records attributed to J Barberá.

At least 37 records · Page 2Linked to original sources
PubMed1987

Fascicular ligation in the prevention and treatment of painful terminal neuroma: an experimental study in the rat.

The role of microfascicular double ligation and interligature coagulation in the prevention of painful neuroma was studied in an experimental model of section of the sciatic nerve in the rat. The experimental parameters used were the onset of autotomy and the weekly autotomy score. The autotomy of the denervated limb is a behavioral pattern that occurs in the experimental animal after the severing of peripheral nerves and has been related to anomalous electrical activity originating from the neuroma. Microfascicular ligation was performed immediately after section of the sciatic nerve or 10 days later. The results were compared to those of control groups treated with simple nerve section or simple neuroma resection 10 days after nerve section. The results show that immediate or delayed microfascicular ligation has no effect on pain as measured by the development of autotomy.

Animals↗
PubMed1986

Spinal cord stimulation in peripheral arterial disease. A cooperative study.

Percutaneous epidural stimulation of the low thoracic spinal cord was carried out in 41 patients with pain from peripheral arterial disease of the lower limbs. Results are reported relating to pain, claudication distance, peripheral blood flow, and trophic lesion changes. Following a trial period of stimulation, 37 patients had stimulators permanently implanted. After a mean poststimulation follow-up period of 25 months, substantial pain relief (75% to 100%) was obtained in 29 cases; claudication distance significantly increased in 15 cases; Doppler ultrasound recordings of lower-limb distal arteries showed a tendency toward normalization of pulse-wave morphology, with increase of amplitude in 12 of the 23 patients studied; a rise in skin temperature was also detected by thermography. Distal arterial blood pressure remained unchanged with stimulation. Ischemic cutaneous trophic lesions of less than 3 sq cm healed, but gangrenous conditions were not benefited. A placebo effect or the natural history of the disease can be excluded as the reason for these improvements. It is concluded that spinal cord stimulation is a valid alternative treatment for moderate peripheral arterial disorders when direct arterial surgery is not possible or has been unsuccessful.

Adult↗
PubMed1985

Centrocentral anastomosis in the prevention and treatment of painful terminal neuroma. An experimental study in the rat.

In this experimental study, microsurgical centrocentral anastomosis was applied to an experimental model of painful terminal neuroma resulting from left sciatic nerve section in the rat. The anastomosis consisted of end-to-end suturing of the sciatic nerve fascicles to the tibial branch, with the interposition of a nerve graft taken from the same anastomosed fascicle. As a control parameter for the experiment, the autotomy which follows sciatic nerve section in the rat was evaluated. Autotomy is considered an objective indication of abnormal sensations that are provoked by the formation of a terminal neuroma. Histological study of the proximal stump of the sciatic nerve was also performed. The observation period was 10 weeks. The study demonstrates that centrocentral anastomosis reduces the size of the neuroma formation and the incidence of autotomy.

Animals↗
PubMed1980

Burr-hole electrocorticography.

In 17 epileptic patients, most of them with seizures of partial type but with diffuse or focal alternating abnormalities in the electroencephalographic recordings, chronic implantation of subarachnoid electrodes was performed. Through two bicoronal burr-holes and under fluoroscopic control, 13 to 19 insulated monopolar flexible electrodes were introduced in the subarachnoid space, conducting them either to standardized cortical targets, or concentrating them in that area of interest showed by conventional EEG. The electrodes were placed bilaterally and symmetrically, and remained implanted for 10 days. During this period, the activity of multiple foci, the reciprocal dependence between them, its reaction to cortical electric stimulation, barbiturate administration and sleep, were studied. No morbidity was found. Because of the simplicity and safety of this technique, it appears to be a good diagnostic method placed between conventional EEG and stereoelectroencephalography.

Electric Stimulation↗
PubMed1980

Septal stimulation on painful and symbolic stress. Experimental study.

Based on the rewarding effect of septal area, therapeutic stimulation of this region has been applied to surgical management of chronic pain. However some basic problems of this technique remain unsolved. Thus the effect of septal stimulation was tested on an experimental model of painful and symbolic stress, comparing the variations in the pituitary-adrenal axis activity, the peripheral catecholamine levels and the structural changes in gastric mucosa and adrenal glands, between the problem and different control groups. The bioelectrical activity of septal area and anterolateral hypothalamus during stimulation were recorded. A decrease in gastric ulceration and plasma cortisol were observed in the septal stimulation group. No direct influence on the catecholaminic system was noted. A facilitation of septal activity and its influence on hypothalamic rythm were found. All these effects were mainly achieved in the posterior perifornical septal region.

Animals↗
PubMed1980

Primary eosinophilic granuloma of the frontal lobe.

The clinical symptoms, pathological findings and surgical treatment of a case of primary frontal lobe eosinophilic granuloma are presented. Initially a frontal mass was detected that clinically seemed like a low-growth tumor. After operation, the histological, cytochemical and ultrastructural studies showed positive acid phosphatase, alpha-naftil-esterase, oil-red and PAS reactions of tumoral cells and the presence of rod-shaped bodies in proliferative histiocytes, all which confirmed the pathological diagnosis of eosinophilic granuloma. Other osseous or visceral histiocytosis-X signs were not observed. The patient remains asymptomatic after a postoperative follow-up of 2 years.

Adult↗
PubMed1979

Stereotaxic pontine spinothalamic tractotomy.

Radiofrequency lesions of the spinothalamic tract in the pons have been made in five patients with pain from malignant disease. In all cases relief from pain in the upper limbs and neck was obtained. No important dysesthesias were reported postoperatively. Findings on stimulation in the target and elsewhere in the pons are described. In one case the lesion was verified on postmortem examination.

Adult↗
PubMed1978

Prophylaxis of the laminectomy membrane. An experimental study in dogs.

Sixty laminectomies were performed in dogs to investigate the prevention of the laminectomy membrane and its side effects. These operations were distributed in six groups of 10, one was a control group, and in the others the bone defect was protected with different materials (Oxicel, Silastic, Dacron, methyl methacrylate, and Kiel bone graft). After a survival of 2 months, suboccipital myelography was performed, immediately after which the animals were sacrificed and the operated spinal slice obtained. The different radiographic densities of the tissues of each slice were calculated and the diverse histological nature identified by hematoxylin and eosin, periodic acid Schiff, Masson's trichrome, and Gomori's reticulin strains. Only the acrylic plastic and the Kiel bone graft prevented expansion of the scar tissue inside the spinal canal and adhesions between the dura and the cicatrical overlying muscles. Therefore, the authors suggest that a solid barrier is necessary to effectively prevent the so-called "laminectomy membrane."

Animals↗
PubMed1977

[Craniosynostosis: a review of 14 cases (author's transl)].

Fourteen cases of single and polimalformative craniosynostosis are presented. A Crouzon's syndrome, and Apert's syndrome and a Carpenter's syndrome are included. On the cranial deformities, 7 cases of scaphocephaly, 4 cases of oxycephaly and 3 cases of acrocephaly were diagnosed. The eye abnormalities, the mental retardation and the intracranial hyperpressure symptomatology were analyzed. A lineal descompresive craniectomy was performed in 10 cases. The applied surgical criterium was the appearing of intracranial hyperpressure. The postoperative results upon the clinical symptomatology and the cranial deformity are commented, showing a real improve of the hyperpressure symptoms in all the cases, a correction of the scaphocephalic defect and a lack of effect on those clinical manifestations resulting from the cerebral damming. Finally, the timing of operation is discussed.

Child, Preschool↗
PubMedDate not supplied

Primary glioblastoma with EGFR amplification and a ring chromosome 7 in a young patient.

Glioblastoma is the most common primary tumor of the central nervous system, but the underlying genetic changes that give rise to these tumors are still poorly understood. We report a primary glioblastoma with an unusual age of presentation. The patient was a 22-year-old man with a survival of 16 months. Morphological findings showed an increase of cellularity with positive GFAP and EGFR expression, increase of proliferate index, vascular hyperplasia with glomeruloid structures and necrosis. Molecular analysis showed EGFR amplification. No mutations of the TP53 or amplification of MDM2 and CDK4 were detected. Neither homozygous deletion of the 9p21 locus genes nor aberrant methylation were found. The cytogenetic study showed a clonal karyotype. The metaphases presented, among other anomalies, a small ring chromosome and double-minutes chromosomes. Using FISH and CGH techniques, it was found that the ring chromosome was a partial trisomy of chromosome 7, and the region implicated corresponded to 7p13-q21. Partial trisomies in glioblastoma could play an important role in defining those regions where genes implicated in this tumor process may be found. We studied the possible correlation of these findings with the tumoral phenotype.

Adult↗