Biomedical subjects
Publications and source records attributed to J Basu.
L-lysine administration to male weanling rats at a dose of 110.4 mg (25% LD50) per 100 g body weight per day for 15 days reduced the liver total ascorbic acid level. The biosynthesis as well as the degradation of L-ascorbic acid was diminished under these conditions. The fall in liver total ascorbic acid level after L-lysine administration was ascribed to its reduced synthesis.
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The effects of administration of L-lysine on total ascorbic acid level of various tissues and plasma of rats were studied. The biosynthesis of L-ascorbic acid by the liver tissue was also followed. L-lysine was administered at a dose of 88.3 mg day-1 (20% of LD50) for each 100 g body weight for 14 days. L-lysine administration at the present dose elevated the total ascorbic acid level of liver, kidney, testes, spleen and brain tissues. The plasma total ascorbic acid level was also elevated. The synthesis of L-ascorbic acid from both D-glucuronolactone and L-gulonolactone by the liver was, however, reduced after L-lysine administration. It has been suggested that L-lysine administration at the present dose altered the plasma amino acid pattern which in turn impaired the in vivo synthesis of tissue proteins and, consequently, the synthesis of apoproteins of ascorbic acid-synthesizing enzymes, the D-glucuronoreductase and L-gulonooxidase, were reduced. The elevation in the total ascorbic acid level of extra-hepatic tissues and plasma after L-lysine administration was ascribed to the reduced catabolism and diminished urinary excretion of ascorbic acid.
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1. The oestrogenic properties of four triphenylethylene compounds were compared. They can be listed as follows in order of their oestrogenic potency: 1-[p-(beta-diethylaminoethoxy)-phenyl]-2-nitro-1,2-diphenylethylene (E.I.P.W. 111) > clomiphene > 1-[p-(beta-dimethylaminoethoxy)-phenyl]-2-nitro-1, 2-diphenylethylene (E.I.P.W. 113)> 1-[p-(beta-diethylaminoethoxy)-phenyl]-1,2-diphenylethylene (E.I.P.W. 103). The oestrogenic potency of compound E.I.P.W. 111 was found to be about 1/10th of that of oestradiol.2. Compound E.I.P.W. 111 is partially antioestrogenic but not progesteronic in nature. It has no androgenic effect.
Bacteriocins of Vibrio cholerae have been demonstrated against enterobacterial and vibrio indicator organisms by conventional techniques. Abundant bacteriocin production took place on casein hydrolysate-yeast extract, tryptic soy, digest broth, proteose-peptone, and neopeptone agars. Essential factors were a citrate-phosphate buffer concentration of 0.5 to 0.7%, at pH 7.5 to 7.6, and cold shock. Thermal treatment of indicator organisms at 45 C for 12 min increased the percentage of typable strains. The bacteriocins of V. cholerae appeared to be powerful diffusible bactericidal agents. By using 8 indicator strains, 11 bacteriocin types have been recognized among 425 strains, of which 87% are typable at present.
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