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Biomedical subjects

J Batchelor

Publications and source records attributed to J Batchelor.

10 recordsLinked to original sources
PubMed1993

Regional cerebral blood flow during memory recognition and neuropsychological performance in patients referred for investigation of dementia.

Regional cerebral blood flow was studied at rest and during a memory recognition activation task in a preliminary investigation carried out in patients with mild to moderate dementia of Alzheimer type and in 2 control groups of subjects. There were differences in the sites of activation-increased blood flows between the normal controls and the controls with major depression, while the Alzheimer's disease subjects showed more variable patterns of flow response, which differed overall from those present in the 2 control groups.

Alzheimer Disease↗
PubMed1992

Neuropsychological abnormalities in patients with pituitary tumours.

Neuropsychological assessment of 65 patients with pituitary tumours revealed impairment of memory and executive function. This did not appear to be related to the size or type of tumour or the effects of radiotherapy or surgery. It is possible that the problems arose from multiple unconnected factors but this observation lends support to the suggestion that pituitary or hypothalamic hormones have a role in the modulation of memory and behavioural pathways. Whatever the cause, neuropsychological impairment is common in patients with pituitary tumours and is an aspect of their disability which has received insufficient attention in the past.

Adenoma↗
PubMed1991

Regional cerebral blood flow and recognition memory in elderly normals: potential application to Alzheimer's disease.

Regional cerebral blood flow, a physiological measure of brain function, has been used for the assessment of cognitive dysfunction in Alzheimer's disease. A number of studies have found diminished temporo-parietal regional cerebral blood flow (RCBF) in Alzheimer's disease patients at rest and have differentiated these patients from normal subjects with a high degree of sensitivity. However the majority of the Alzheimer's disease patients have been in the moderate to severe stages of the disorder. Few studies have assessed RCBF in the early stages of Alzheimer's disease. With increasing emphasis now being placed on the early detection of such patients we chose to examine RCBF during a task which made demands on those cognitive processes which are impaired in the early stages of the disease, viz. a recognition--memory task. Using a 32-channel RCBF system, we examined 20 normal control subjects over the age of 60 years and 10 patients with early to moderate Alzheimer's disease. RCBF was examined during a task of recognition--memory, and also at rest. Normal subjects showed a global increase in RCBF, with marked left frontal activation, as compared with when at rest. Resting perfusion was decreased in the Alzheimer's subject, and there appeared to be a greater degree of intersubject variability in flow during activation.

Aged↗
PubMed1989

A simple method for measurement of the haemoglobin binding capacity of canine haptoglobin.

The potential of a series of related compounds to induce haemolytic anaemia in dogs highlighted the need for a reliable and sensitive technique to identify changes in plasma haptoglobin concentration. An indirect method established for human samples was adapted for use with canine plasma. This method measures the haemoglobin binding capacity of plasma, which is directly proportional to the functional haptoglobin concentration. The efficacy of this technique was investigated on samples taken from Beagle dogs which had previously received small quantities of water intravenously. A substantial reduction in haemoglobin binding capacity was recorded before other haematological parameters were significantly affected. It was concluded that measurement of haemoglobin binding capacity by this method provides a valid reflection of haptoglobin status in the dog.

Animals↗
PubMed1986

Preliminary validation of a clinical scale for measuring the duration of post-traumatic amnesia.

An operational definition of post-traumatic amnesia is presented and a standardized procedure for the measurement of post-traumatic amnesia, which has been clinically tested in over 100 patients with severe, closed head injury is described. Twenty patients with severe head injuries who were still experiencing post-traumatic amnesia (as defined in this study), were assessed on an independent test of learning ability, as were 20 other patients with severe head injury who were no longer suffering post-traumatic amnesia. The performance of the two groups differed significantly; those in a state of post-traumatic amnesia performed more poorly. Both these groups showed significant impairment when compared with a control group of 20 patients who were in hospital because of orthopaedic injuries that were suffered during a motor vehicle accident. These preliminary results are sufficiently encouraging to recommend this simple procedure for routine use in hospitals, to enhance the accuracy of measuring the severity of head injury. The medicolegal use of this measure is also discussed.

Adult↗
PubMed1980

Data processing in microbiology: an integrated, simplified system.

A MUMPS based computer system is described for the processing of data in a microbiology laboratory. The system uses visual display units and mnemonic codes for data input. All functions are carried out within the department by the medical, technical, and clerical staff. While the system described is integrated with other user-systems in the hospital, it is readily adaptable, and portable to a stand-alone system.

Laboratories↗
PubMedDate not supplied

Post-coma disturbance and post-traumatic amnesia as nonlinear predictors of cognitive outcome following severe closed head injury: findings from the Westmead Head Injury Project.

This study sought to identify combinations of early neurological variables which best predict cognitive outcome 12 months after severe head injury. At the time of admission patients were assessed on seven neurological indices. Twelve months later a battery of neuropsychological tests examining recent memory functioning and speed of information processing was administered. Recent memory functioning was best predicted by a combination of post-coma disturbance (PCD; i.e. the duration of post-traumatic amnesia, PTA, minus the duration of coma) and presence of subarachnoid haemorrhage (multiple r = 0.54, p < 0.001). Speed of information processing was best predicted by the duration of PTA (r = 0.35, p < 0.01). However, these conclusions were based on square root transformation of PCD and PTA variables. The success of this transformation in assisting prediction confirms suggestions that the relationship between PTA and cognitive outcome is nonlinear.

Adolescent↗