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Biomedical subjects

J Belaïsch

Publications and source records attributed to J Belaïsch.

15 recordsLinked to original sources
PubMed1993

[Should we treat the man or his sperm?].

The treatment of male hypofertility should not be started if spermatogenetic dysfunction is not clearly established. Under 5 millions spermatozoa/ml, it appears that male fertility is generally present. Further fertility investigations should always be continued in the female in such a case. The multiple ways, mainly hormonal in nature, of probable spermatogenetic stimulation and the conditions in which it is wiser to resort to medically associated procreation are analysed.

Fertilization in Vitro↗
PubMed1993

[The latest progestagens].

The new progestative molecules have allowed to reduce the doses of steroids in the combined pills. They have a reduced androgenic activity allowing the positive effects of ethinyl estradiol to act on lipid metabolisms, which may lead to a reduction of atherogenesis. However these new pills should not be administered if the classical contraindications exist. On the contrary the strong gonadotropic effect of the latest nor-pregnane derivates can be used (the chlormadinone as well) on patients with thromboembolic history on the condition that the still partially experimental aspect of this mode of contraception is taken into consideration.

Arteriosclerosis↗
PubMed1993

[Progestagens and bones].

Gestagens when administered alone to menopausal women, (19 nortestosterone or progesterone derivatives) suppress loss of mineral content. But often a slight bone loss is observed, in contrast to the effect of oestrogenotherapy. 19 norpregnane derivatives seems to protect against bone loss. Progestagen may enhance bone formation without decreasing bone resorption. Administered together with oestrogens, gestagens have demonstrated either a decrease in biochemical estimates of bone loss or a radiologically positive effect. Progestogens alone in premenopausal women have various effects. In the case of contraception by injectable MPA the bone mass tend to decline as a result of hypoestrogenism. In summary gestagens seem to have on bone mass a rather favourable effect, which nevertheless is weaker than that of oestrogen.

Bone Density↗
PubMed1990

[Endometriosis and sterility].

Relations between endometriosis and infertility are complex and difficult to establish. Numerous theories have been suggested, but none of them has proved conclusive. As always in case of endometriosis, medical and surgical treatments are open to discussion. The right time for medically assisted procreation is obvious in patients with tubal obstruction but in the others it varies according to age, duration of infertility and previous treatments.

Endometriosis↗
PubMed1989

[Progress in combined oral contraception: gestodene, a third generation progestogen].

Gestodene is a new progestogen of the 13-ethyl series. Its novel pharmacological profile (powerful anti-ovulatory and progestomimetic activities, low androgenic activity) means that it can be suggested for use in very low doses in combination with ethinyl estradiol. Studies carried out using a three-stage combination containing Gestodene (Phaeva) have failed to demonstrate any detrimental effect on either lipid or carbohydrate metabolism. The results confirm the advantage of using this third generation progestogen over the very long term.

Animals↗
PubMed1983

[Exposure to diethylstilbestrol during intrauterine life. Signs that should suggest this. Therapeutic implications].

From now on it is general knowledge that there is marked increase in the frequency of clear cell cancers of the cervix and of the vagina in daughters whose mothers were given diethylstilboestrol (DES) during their pregnancies. Equally well known is the high fréquency of vaginal adenosis in these patients. Since 1977, moreover, several North American writers have commented on the lowering in reproductive capacity of these women. It seems that women who were exposed to DES in utero had a greater frequency of extra-uterine pregnancies, spontaneous abortions, and perinatal mortality of their offspring as compared with carefully selected control series. These complications seem to have a predilection for women who have abnormal cervices of who have a T-shaped hypoplastic uterus found on hysterosalpingography. Recently it has been found that there is a higher level of female sterility as compared with male sterility in these patients. Reviewing the literature and describing the principal abnormalities has made it possible for us to produce a hypothesis. This should explain how the action of DES on the mesonephric canals of Wolff causes changes in the shape of the uterus.

Diethylstilbestrol↗
PubMedDate not supplied

[Pro clomiphene].

Thanks to CC an important number of endocrine sterility has been cured. The antiestrogenic effect of CC has been accused to promote perturbations of cervical mucus secretion and endometrial receptivity. The different technics to assure correction of negative side effects while promoting optimal activity of clomiphene will be discussed in terms of modern evaluation methods.

Abnormalities, Drug-Induced↗