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Biomedical subjects

J Benz

Publications and source records attributed to J Benz.

At least 37 records · Page 2Linked to original sources
PubMed1992

Antidiabetic agents and lactation.

If the dose of insulin and adequate carbohydrate intake is ensured, most diabetic mothers taking insulin will be able to breastfeed satisfactorily. Compared to the dose before pregnancy, the required insulin dose probably will be substantially reduced during breastfeeding. The American Academy of Pediatrics recommends tolbutamide as the preferred oral hypoglycemic agent during the breastfeeding period; however, the infant should be monitored closely for signs of jaundice. The mother should be monitored using a method specific for glucose, since lacturia may interfere with nonspecific methods of urine glucose measurement. It is important to monitor for ketones in the mother because acetone is excreted in breastmilk and may adversely affect the infant's liver.

Diabetes Mellitus↗
PubMed1992

[Is follow-up of breast cancer with CEA and CA 15-3 justified?].

The significance of the tumor markers CEA and CA 15-3 for the oncological follow-up of breast cancer was examined in a retrospective analysis of 274 patients. Only 45% of 225 patients with nonmetastatic breast cancer showed in a period of 3 years normal values for both markers. 123 patients with increased markers in the same period were without evidence of tumor progression. Neither marker is suitable for the diagnosis of a local recurrence. In 32 cases of distant metastasis CA 15-3 is more sensitive than CEA (88%/63%), with an increase of 3% in sensitivity when analysing both markers simultaneously. The cut off level of CA 15-3 is problematic, 25 U/ml or 40 U/ml can be used as a threshold for tumoral activity. The use of tumor markers in the follow-up is not really justified so long as the prognosis or mortality of a patient is not changed by starting therapy early.

Antigens, Tumor-Associated, Carbohydrate↗
PubMed1992

[The value of the localization technique of occult breast changes with reference to future screening programs].

A retrospective study of 54 needle localisations of occult mammographic lesions by the technique of Brun del Re shows an easy and precise handling of the method without serious complications and emphasizes the favourable result of the localized breast cancers (a lot of non-invasive cancers, small average size of the cancers, most cases with nodal negative state). Our results are compared to a literature review. The discussion demonstrates the importance of localisation techniques in the set-up of screening programs.

Biopsy, Needle↗
PubMed1992

[Breast cancer: locoregional recurrence and subsequent disease course].

The survival of 409 patients with breast cancer treated by surgery +/- adjuvant therapy is controlled in a retrospective study. 65 (15.9%) patients subsequently suffered from loco-regional recurrences. 41 (63.1%) of these patients showed either simultaneously with the loco-regional recurrence or at the latest within 2 1/2 years after the diagnosis of the loco-regional recurrence distant metastasis. The incidence of the distant metastasis is the more probable the shorter the interval between the primary treatment and the occurrence of the loco-regional recurrence. More prognostic factors for the survival after the diagnosis of the loco-regional recurrence are discussed.

Breast Neoplasms↗
PubMed1990

[Pseudotumor cerebri in pregnancy].

This is undoubtedly a rather rare clinical picture. The existence of a brain pressure syndrome with symptoms such as headache, increased cerebrospinal fluid pressure, and diplopia simulates a brain tumor, even though the radiological and tomographical evidence is absolutely normal. Therapeutic possibilities are steroid medication, lumbar punctions, as well as a neurosurgical intervention installing a lumboperitoneal drainage. We deem the initial dosage of 16 mg Millicorten/day to be therapeutically effective and adequate.

Acetazolamide↗
PubMed1989

[Early detection of environmental chemicals in food by means of specific substance criteria].

In an approach to selecting potential food contaminants by means of specific substance criteria we came up with a list of 68 chemicals. Among them, we found chemicals which are already well known as food contaminants such as polycyclic aromatic hydrocarbons and chloroaromatic compounds. So far, other chemicals have not been mentioned as food contaminants. During a project called "Information System for Environmental Chemicals" we conducted, for these 68 chemicals, an intensive literature search in databases for their occurrence in food. The results are stored in our factual databank named "LEBKON" and are graphically described in profiles. For 44 of the chemicals, we found information for their detection in food or in drinking water. We plan to analyse the remaining substances for which no data have been found in the literature. We placed emphasis on the toxicological properties and the production volume of the substances in question. This approach should represent a contribution to the question of monitoring systems oriented by the consumer and monitoring systems oriented by cause.

Animals↗
PubMed1989

[Labor without prenatal care--an unnecessary challenge].

A group of 431 patients who had given birth, but had not attended regular check-ups during their pregnancy, are compared with a cumulative comparative group. The data is from a databank, belonging to the Swiss gynaecological working group. The following results are striking: Very young women, relatively older childbearing women, a noticeably high number of unmarried women and women from the Mediterranean countries. The number of women with heavy nicotine abuse is significant. The general progress of the pregnancy is however not noticeably different from the comparative group. The premature birth rate is higher in the group without pregnancy check-ups, as are birth deficiences and clinical foetal distress. Particularly noticeably is the high number of perinatal deaths. The pointlessness and the possible reasons for lack of regular pregnancy check-ups are discussed.

Adolescent↗
PubMed1989

[The Pena-Shokeir syndrome].

The Pena-Shokeir syndrome is undoubtedly a rare clinical picture. The aim of this work is to introduce this syndrome, which was first described 14 years ago, and to show the (limited) possibilities of intrauterine diagnosis. The fact that the etiology of the Pena-Shokeir syndrome is still discussed indicates the necessity to expand our knowledge on this clinical entity.

Abnormalities, Multiple↗
PubMed1988

[Colorectal carcinoma following radiotherapy of gynecological carcinoma].

To assess the risk of radiation-induced cancer of the colon we studied 196 patients with a history of radiation treatment for cancer of the female genital system. After a median follow-up of 12.4 years (range 10-15 years) corresponding to 1172 patient-years, 94 (48%) patients were still alive. 84 (89%) of these patients were evaluated for a second primary cancer to the colon. In 38 (45%) colonoscopic examination was performed. 3 patients were found to have a second primary cancer to the colon compared with 0.32 expected (relative risk 9.3) on the basis of rates from the Zürich Tumor Registry. Due to partial long-term survival, patient non-compliance and non-feasibility of colonoscopic examination, only one fourth of all patients initially treated by radiotherapy for cancers of the female genital system were suitable for colon screening. For these high risk women, colorectal tumor screening should be integrated into a gynecologic tumor follow-up.

Adult↗
PubMed1988

[Childbirth in 2 patients with congenital analgesia].

Pregnancy and labour in two cases of congenital analgesia are reported. Not only was there total absence of labour pains but also no perception of uterine contractions. In both cases the women did not notice the onset of labour till the moment of spontaneous rupture of the membranes. Due to the absence of bearing down efforts, expulsion ceased for several hours in the second stage; nevertheless, delivery followed spontaneously. As the patient is unaware of labour, fetal asphyxia may occur during the second stage if the child is not under technical control. Stillborn children have been reported. For this reason we recommend programmed birth in cases of congenital analgesia.

Adult↗
PubMed1987

[Laparoscopy in gynecology and obstetrics].

Thanks to the statistics of the Arbeitsgemeinschaft Schweizerischer Frauenkliniken (Swiss Gynecological Clinics' Working Group) it has for the first time become possible to report on larger numbers of laparoscopies performed in Switzerland. In contrast to most international statistical records, data relating to this subject are gathered prospectively; there is no doubt that this improves the quality of the data. The authors report on a total of 18,186 laparoscopies performed in 1983/84/85, in 50% of the cases for sterilization. The various sterilization methods employed are discussed. As far as diagnostic laparoscopies are concerned, the indications and techniques are described. Serious intraoperative complications occurred in 15 cases, which corresponds to one serious complication in every 1,212 laparoscopies. Fortunately, not a single patient died as a direct result of the laparoscopy. The results are compared with those in the international literature. With regard to late-onset morbidity it is evident that there are more complications with the more complex procedure of diagnostic laparoscopy.

Female↗
PubMed1987

[Obstetric-gynecologic data collection for quality control and responding to health and political status questions. A survey based on 250,000 patients].

Since January 1, 1983 a total of 250,000 patient records have been stored in computer-compatible form in the data base of the Working Group of Swiss Gynecologic Clinics (59 gynecologic-obstetric departments). The information resulting from this mass of data is commented on and analyzed in concise form. Problems of quality control, health care and status-related policies can be addressed and resolved on the basis of up-to-date data which are always available. In the authors' experience, the benefit of correctly compiled statistics is indisputable.

Cesarean Section↗