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Biomedical subjects

J Berlie

Publications and source records attributed to J Berlie.

At least 19 recordsLinked to original sources
PubMed1992

[Retrospective study of 139 cases of epidermoid carcinoma of the upper respiratory and digestive tracts treated by induction chemotherapy with cisplatin-5FU. Influence of the result on the therapeutic protocol].

A retrospective study of 139 untreated staged III and IV epidermoid carcinomas of the upper aero digestive tract is reported concerning oropharynx, oral cavity, hypopharynx and larynx, all of them received as a first treatment, chemotherapy using a five days course of Cisplatinium (20 mg/m2/D) and 5FU (1,000 mg/m2/D). The aim of the trial was to determine: a) a free of disease survival and a global survival rate's increase, b) a more conservative treatment. The results of chemotherapy were clinically evaluated in two groups: Responders (a total or a more than 50% response), and no responders. The results were: on the tumor site: 64% responders (25% total response)--more in smaller lesion; on the lymphatic nodes: 54% responders (more in N1-N2). The results vary in inverse ratio to the stage of the lesion; usually, 2 cycles of chemotherapy are used but in case of efficiency: 2 to 6 cycles are provided increasing to 20% the rate of the total responders; toxicity of the drugs was neligible: 6 cases, 3 of them were renal insufficiency. The global survival rate at 3 months reaches 56.7%. The median line of survival reaches 32 months in responders reverse 15 months (NR); but there are no significant difference between the two groups concerning the recurrences, or the metastasis. The local treatment (after chemotherapy) decided in the 137 patients was surgery, in 40 cases and radiotherapy, in 97 cases (conservative treatment; 80%).(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1991

Polyadenylic-polyuridylic acid plus locoregional and pelvic radiotherapy versus chemotherapy with CMF as adjuvants in operable breast cancer. A 6 1/2 year follow-up analysis of a randomized trial of the French Federation of Cancer Centers (F.F.C.C.).

In this study, patients with operable breast cancer T2 or T3, treated by mastectomy + axillary dissection and with invaded axillary nodes (N+), were randomized to receive either: 1) postoperative locoregional and pelvic radiotherapy (RX) and Poly(A).Poly(U) (AU), 60 mg IV once a week for 6 weeks, or 2) CMF (cyclophosphamide 100 mg/sqm P.O. on days 1-14, methotrexate 40 mg/sqm IV on day 1 and 8, fluorouracil 600 mg/sqm IV on day 1 and 8; monthly cycle, for 6 months. Between March 1982 and December 1985, 517 patients were enrolled, 257 of whom were treated by RX + AU and 260 with CMF. The main clinical, pathological and prognostic characteristics were equally distributed in the two groups. The present analysis was conducted after a mean follow-up of 69 months (S.D. = 13). There was no significant difference in overall survival (OS) between the two groups (test adjusted by center and menopausal status); the five-year OS rate was 74% in the RXAU group and 77% in the CMF group. Relapse-free survival (RFS) was significantly higher (p = 0.05) in the RXAU group compared to the MCF group; the five-year RFS rates were 57% and 46% in the two groups respectively. This short, well-tolerated combined RXAU treatment appears to be as efficient as CMF and might offer an alternative to chemo- or hormonotherapy, in case of contraindications to these treatments.

Adult↗
PubMed1990

[Epidemiologic and prognostic factors of cancer of the breast].

Breast cancer is the most common of all cancers affecting women in France; its frequency increases in countries with a high standard of living. A family history and certain types of mastosis are unquestionable risk factors, although their weight has not yet been well established, but there is no absolute proof that feeding habits (notably fats and alcohol), which have been blamed by some authors, play a role in the genesis of breast cancer. Among the classical prognostic factors, which are necessary for surgical decisions, the size of the tumour, its histological grade and above all the number of axillary lymph nodes involved are the most important. However, a better knowledge of breast cancer biology has yielded factors that seem to be more promising than hormonal receptors, notably the DNA content of tumoral cells and the presence or absence of a protease, procathepsin 52 K, which reflects tumoral aggressiveness. As for the study of oncogens described elsewhere in this monograph, it will provide a better definition of high risk subjects and more precise information on the progress of the cancer.

Adenocarcinoma↗
PubMed1985

[Cancer of the prostate. Epidemiologic evaluation, incidence, and trends, especially in France].

With 7,172 deaths in 1982, prostatic cancer is a frequent cancer in France observed among old men, coming just after the lungs cancers and representing 9.6% of male mortality from malignant disease. Its incidence in the French regional population based on departmental registries is about 25/100.000 (age adjusted to the world standard population). The geographical distribution throughout the world shows a high incidence rate among the black american, the Scandinavian countries and low rates in the south-east of Asia. As well as incidence as for mortality low trends of increase all over the world are observed. In the clinical data from the "Enquete Permanente Cancer" (E.P.C.) the high proportion of metastatic dissemination (48%) at initial time of diagnosis, and also the high proportion of epithelial cancer (92%) emerge from a series of 1,223 prostatic cancer registered between 1975 and 1982. The 9 year-survival relative rate (32%) for the whole group lets appear a level of cure observed after the 8 years of follow-up. Few risk factors have been yet recognized so that it is not easy to identify risk population and propose them any preventions.

Adenocarcinoma↗
PubMed1979

[Mortality due to carcinoma of the stomach between 1954 and 1974. Changes in France (author's transl)].

A study of changes in mortality due to carcinoma of the stomach in France between 1954 and 1974 was undertaken on the basis of probable levels standardised on the French population in 1968. There was a marked fall in this mortality for both sexes. In the male, the initial level in 1954 was 54.8/100 000 and the decrease was of the order of 1.35 deaths per 100 000 per year, i.e. an annual fall of -3.21%. This phenomenon was more marked during the second period (1965--1974): - 3.88%, than during the first period (1954--1963: - 2.38%. In the female, with an initial mortality rate of 31.25/100 000, the annual decrease was 31.25/100 000, i.e. an annual fall of - 3.49%. This fall was - 3.09% for the first ten year period and - 4.80% for the second period. Thus in France, in common with many other countries, there has been a marked decrease in mortality due to carcinoma of the stomach, for both sexes, and this phenomenon became progressively more notable during the period of the study.

Female↗
PubMed1979

[Mortality of bladder cancer in France: 1952--1976. Trends and increase, particularly in the South of France (author's transl)].

Trends in mortality from bladder cancer have been described with several statistical methods using bi and multivariate analysis. Between 1952 and 1976, the mortality by bladder cancer was marked by an increase for both sexes with a predominance among the males (annual increase + 3,65%, against 1.34% among the females). In 1976, the age-adjusted rate/100,000 of mortality was 11,35 for males and 3,20 for the females showing an high sex-ratio. The computerized mapping of this cancer geographical distribution shows a significant predominance in the south of France and also a high statistically significant correlation with the geographical distribution of lung and gallbladder cancer mortality in France.

Adult↗
PubMed1979

[Mortality of carcinoma of uterine cervix in France : 1950-1976, trends and geography (author's transl)].

A study of changes in mortality due to carcinomas of cervix uteri in France between 1950 and 1976 was undertaken. Rates increased slightly over the whole period (0.44% per year). However, from 1950 to 1968 there was an increase (1.9% per year) and from 1969 to 1976 a decrease (1.17%). This decrease may be due partly to improvements in diagnosis, screening and cure. The geographical distribution has not shown any regional particularity. There is a high significant correlation with geographical distribution of breast cancer mortality, a hitherto unknown finding in France.

Adult↗
PubMed1977

[Breast cancer in man].

Mortality from carcinoma of the breast in man varied from 0.6 to 0.8 per 100,000 from 1950 to 1970. Over the same period the equivalent figures in women were 22 to 29 per 100,000. From 1955 to 1968, the Enquête Permanente Cancer recorded 537 cases of carcinoma of the breast in men. 293 of which were seen before any treatment. This last group is described with respect to the age of the patient, the topography of the tumour, the histology, the tumor node metastasis and treatment. Survival rates were as follows: 39.2% at 5 years, 23.7% at 10 years and 16% at 20 years. The relative survival was 49% at 5 years, 37.5% at 10 years and 43.8% at 20 years. These results are identical to those published for numerically similar series. In this enquiry, a comparison between the results of carcinoma of the breast in men and women showed no difference.

Adolescent↗
PubMed1977

[Polychemotherapy of advanced breast cancer. Triple combination with doxorubicin. Analysis of 209 observation].

Two hundred and nine patients with breast cancer in an advanced stage were treated according to a chemotherapeutic regimen associating doxorubicin, vincristine and methotrexate, administered in courses of 5 days every three weeks. This analysis deals only with the short range results; they confirm those of a previous randomized study. A global objective response was obtained in 187 cases (89%) and a measurable regression of the lesions in 150 cases (71%); in these later cases 90 (43%) had a regression of more than 50 per cent. The most striking effects, often rapidly observed, involve sites which are not generally sensitive: liver (40%), pleura (24%) and bone (only 6%, but 8 times out of 10 a definite action on the pain syndrome). Side effects were, on the whole, acceptable (only one severe hematologic complication); however, the risk of myocardiac toxocity due to the accumulation of doxorubicin limits the utilization of this association. It thus needs to be relayed by other drug regimens which are included in a program of long term action, but has interesting characteristics as induction chemotherapy.

Adult↗
PubMed1977

[Relations between biomedical variables: mathematical analysis or linear algebra?].

The authors, after a short reminder of one pattern's structure, stress on the possible double approach of relations uniting the variables of this pattern: use of fonctions, what is within the mathematical analysis sphere, use of linear algebra profiting by matricial calculation's development and automatiosation. They precise the respective interests on these methods, their bounds and the imperatives for utilization, according to the kind of variables, of data, and the objective for work, understanding phenomenons or helping towards decision.

Mathematics↗
PubMed1977

[Use of models in the study of survival in oncology].

Observation of numerous survical surves connecting the survival rates with time usually expressed in yearly intervals has permited the elaboration of patterns describing survival probability in terms of time. Gross survival patterns, from which the most utilized is the exponential pattern, must be distinguished from comparative surival patterns that debouch into the recovery probleme. Their interest is to caracterize survival for a group of patients with the assistance of a limited number of values (three at most). From that, follow their practical applications: comparison between several groups that may differ either from the characteristics of the discase or from the received treatments and from the vital future forecasting, either on one group's level, or for an individual.

Mathematics↗
PubMedDate not supplied

[Cancer mortality in France. New Aspects of the presentation and analysis of data].

In France mortality statistics are the only complete source of information on cancer. Investigation of the annual figures and the application of statistical methods to their presentation and analysis has facilitated fresh studies of geographical pathology, utilizing methods of analysis with simple and multiple correlations (analysis of correlations). Certain groupings were thus revealed, notably in the case of death from bronchial carcinoma, urinary bladder and gall bladder. Two groups of departements appeared the nearest to the national levels for deaths from cancer for all body sites.

Computers↗
PubMedDate not supplied

[The chemotherapy of advanced breast cancer. A report on the first 600 cases in a cooperative programme to carry out a systematic study (1974-1977) (author's transl)].

The authors explain the objectives and the structure of a programme evolved for the methodic study of advanced breast cancers which they have worked out and carried out in cooperation with the departments of medicine in eight French anticancer centres. They analyse the initial phases, which correspond to the three first years of work. They give the state of the results that have been obtained in 603 patients using three protocols for treatment. These consisted of the administration in interrupted doses of chemotherapy which consisted of vincristine associated for the one part with cyclophosphamide and 5-fluoro-uracil and on the other hand with doxorubicine or/and with methotrexate. From this study there emerged the value of combined therapy using doxorubicine as much because of the frequency with which results better than 50% were obtained (in a randomised trial) as by their quality, which was made clear in an important series of 240 cases. They point out the conditions required to initiate the place of such a scheme in all complex therapy which aims as much at palliation as at cure, and point out how important it is to be methodical in the application of chemotherapy in order to ensure its development as an anticancer therapy.

Antineoplastic Agents↗