Biomedical subjects
Publications and source records attributed to J Bertling.
We report on a case of the rare entity of multilocular cystic nephroma. The clinical symptoms, the problems with differential diagnosis and the therapy are described. The histological findings, origin and classification are discussed.
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The tissue distribution of intravenously injected native and enzyme-treated human gammaglobulin has been investigated in human rectum mucosa. FITC-labelled antibodies to human gammaglobulin were used to locate the injected antibody preparation. Three hours after application of these different gammaglobulin-preparations no enrichment in the mucosa was found. Neither the native gammaglobulin nor the enzyme-treated gammaglobulin showed any concentration in the lamina propria of the large bowel mucosa or an intracellular enrichment in the epithel. This study shows that the quicker elimination of enzyme-treated gamma-globulin from the circulation cannot be explained by an intracellular increase.
In the parenchymal cells of the liver of adult male rats re-fed on the evening of the fifth day after a period of absolute starvation, a nearly complete absence of autophagic vacuoles (AV) has been found by the morphometric determination of the fractional cytoplasmic volume of AV. The mean value for that parameter increased only gradually during periods of re-feeding. The value was found to be in the range of the control values only on, or after, the fifth day of re-feeding. As in previous experiments, in the control animals the number of AV was again found to be dependent on a circadian rhythm with maxima during the light, and minima during the dark, periods. This rhythm reappeared in the period of re-feeding without a shift in phase. In the controls as well as in the re-fed animals the "segregated fraction" was highest for microbodies, intermediate for mitochondria and glycogen, but rather low for the remaining components of the cytoplasm. It is suggested that the long term inhibition of cellular autophagy, found in the present study, plays an important role in the restorative cellular growth of the liver during the recovery from the atrophy induced by starvation.
Based on a personal case of congenital arteriovenous fistula we discuss the problem of the surgical treatment of this disease. Surgical treatment is always indicated in any case of systemic haemodynamic effects. The surgical treatment is not always successful as the fistula cannot always be exactly located. Another problem is the development of new circuits in regions mo-e proximally situated. This results in a high volume shunt, even if the more peripheral anomalies seem to have been removed completely. It is not sufficient to disconnect and resect the main arteries, without removing the fistula or the angioma, or new collateral vessels and trophic changes will be seen.
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