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J Bidziński

Publications and source records attributed to J Bidziński.

At least 19 recordsLinked to original sources

Cerebral gangliogliomas. Morphological and immunohistochemical study.

Report concerns 6 uncommon cases of cerebral ganglioglioma in adult patients, the majority of whom (4) demonstrated typical classic features, others were anaplastic. Both types presented neuronal and glial components characterized either by NF, NSE and Syn or GFAP immunoreactivity. Only the tumor of the youngest patient presented moderate desmoplasia. Observations indicate at an easy classification of glial component contrary to neuronal component in relation to the origin of neuronal changes.

Adolescent

[Diagnosis and treatment of Cushing's disease].

Authors present the results of surgical treatment of 63 patients with Cushing's disease. They evaluate various diagnostic procedures, applied to define the aetiology of endogenous hypercortisol. The petrosal sinus sampling for ACTH level is described. In the series in only 32% of patients; radiological examinations (including CT and MRI) showed the pituitary adenoma. Among 63 operated persons--43 were subjected to surgery based on endocrinological data alone. All the patients were operated by transsphenoidal route. Good result--endocrinological recovery in the treatment of Cushing's disease was achieved in 80% of patients.

Adolescent

Supratentorial astrocytoma associated with arteriovenous malformation. Case report.

A case of the 18-year-old boy suffering from epilepsy since 8 years and suspected of microangioma is presented. The craniotomy revealed left parietal parasagittal superficially located neoplasm and arteriovenous malformation beneath. Unexpected fibrillary astrocytoma associated with vascular tumor was the diagnostic problem, solved histologically after the operation. The problem of coexistence of various neoplasms with arteriovenous malformations is discussed.

Adolescent

Successful prevention of neurological deficit in SAH patients with 2-chlorodeoxyadenosine.

Twenty patients suffering from subarachnoid haemorrhage due to ruptured intracranial aneurysm and operated on within 72 h after SAH were treated with an experimental immunosuppressive drug 2-chlorodeoxyadenosine (2-CDA), dose 0.05 mg/kg/day i.v. for 7 days. The 2-CDA treatment was started immediately after angiographic confirmation of ruptured aneurysm, and the standard pharmacological treatment (nimodipine and steroids) was also given. 50% of patients were severely threatened by "delayed vasospasm" or late neurological deficit (Fisher's score 3 or 4). The neurological outcome (assessed 8-12 weeks after SAH) was good (GOS = 1) in 70%, and fair (moderate disability, GOS = 2) in 25%. A single case of severe disability (GOS = 3), as well as two cases of less than perfect outcome (GOS = 2), were related to unusual pre- or intraoperative complications. We conclude that the low doses of 2-CDA can be considered as a valuable adjunct to the standard pharmacotherapy of SAH patients operated on early.

Adult

Glial differentiation in medulloblastoma. Case report.

A 30-year-old man suffered for a year of a typical syndrome of cerebellar tumor. At suboccipital craniectomy a soft tumor infiltrating both hemispheres and vermis, filling up part of the IV ventricle was found. After subtotal removal of the neoplasm the postoperative course was poor and the patient died 5 weeks later. Biopsy material consisted of three types of tissue: 1. large nests of carrot-shaped, hyperchromatic cells, 2. fields of "halo" cells presenting myelin basic protein (MBP) immunoreactivity and 3. fields and scattered strongly GFAP-positive cells. The histological and immunocytochemical pattern of the neoplasm indicates differentiation of the tumor into oligodendrogliomatous and astrocytomatous line being an uncommon example of dual glial differentiation capability in medulloblastoma.

Adult

The results of the surgical treatment of occipital lobe epilepsy.

Out of 502 patients with surgically treated drug-resistant chronic epilepsy (tumour cases excluded) in 12 (2%) a clear occipital focus was found. The pattern of seizures was in most cases nonspecific and polymorphic. EEG examination and neuroradiological findings led to proper localization of the epileptogenic focus. Partial or total occipital lobectomy was performed. Follow-up from 4 to 20 years revealed a satisfactory result in 11 of the surgical cases. One patient was lost to follow-up. Brain scarring was found in the histological examination of specimens in 9 out of 12 patients. The results of the surgical treatment of occipital lobe epilepsy are much better than in other localizations of epileptogenic foci.

Adolescent

Risk of epilepsy after aneurysm operations.

This prospective study was undertaken to evaluate the risk of epilepsy after aneurysm operations. The patients were discharged after operation without any anticonvulsant prophylactic treatment and followed-up for 12 months. Out of 128 such patients 121 were submitted for final evaluation. Epilepsy was diagnosed if two or more seizure attacks occurred during that time. Such attacks occurred in 8 patients, so the risk of epilepsy was estimated at 7% for the 12 months after operation in patients without prophylactic treatment. In another 3 patients single seizures occurred during the follow-up, they were not treated with anticonvulsant drugs; seizures did not recur for up to two years. Detailed analysis of the patients with late epilepsy revealed that most of them were pre-operatively in the 3rd clinical group according to WFNS scale. The rationale for the use of prophylactic anticonvulsants after aneurysm surgery seems to be doubtful in view of this study and data from the literature.

Adult

Neuropathological changes in resected temporal lobe of patients with cryptogenic epilepsy.

The study was performed on cerebral tissue resected during temporal lobectomy in 16 patients whose long-standing cryptogenic epilepsy did not submit to anticonvulsive drugs. Cases presenting definite etiological factors such as CNS trauma, infection or neoplasm were excluded. Neuropathological investigations disclosed microangiomas and focal vascular malformations in the meninges and tissue in 7 patients. Neuronal heterotopias in the white matter and of the white matter in the cortex were observed in 3 cases. Main cortical changes were: neuronal loss, chronic neuronal degeneration, perineuronal satellitosis, and GFAP-positive submeningeal gliosis, especially at the bottom of sulci, perivascular gliosis and laminar or diffuse gliosis. The changes in the hippocampus were most enhanced in the end-plate and in the sector H3 of the pyramidal layer. Astrocytic gliosis in the white matter presented distinct GFAP and S-100 immunostaining; the latter involved in some cases a wider area than the GFAP reaction. The above named changes are analysed with regard to the presumed epileptogenic factors and to the postepileptic damage.

Adolescent

Formation of new aneurysms. Report of five cases.

Among 964 patients diagnosed and treated for intracranial aneurysms in 5 evidence of formation of new aneurysms was found. Repeat angiography, performed after the second SAH, revealed new aneurysms on arteries normal on previous angiograms; there were multiple aneurysms in 3 cases. In 4 cases, the aneurysms were formed within 3 to 6 years. In the authors' opinion, the possibility of formation of new aneurysms after the cure of a demonstrable one, should be considered in all aneurysmal patients, especially in multiple cases. Possible mechanisms of development of new aneurysms are discussed.

Adolescent

Acute surgery in intracranial aneurysms. Experience with 100 cases.

In the last 3.5 years (up to August 1988) out of 450 patients with surgically treated intracranial aneurysms in 100 cases (22%) acute surgery was performed (up to 72 h after SAH). Patients in grade I-III (WFNS scale) were operated upon. In all the cases there were supratentorial aneurysms. CSF drainage during the operation was used routinely and nimodipine topically, in intravenous infusion and orally was applied. In all the cases, but one, the aneurysms was clipped. Follow-up--1 year. Assessment of the results was done using the Glasgow Outcome Scale (GOS). Full recovery was obtained in 78 patients and further 5 patients are independent. There were 14 deaths, in 7 patients due to postoperative vasospasm. Symptomatic ischaemia developed in 25 patients, however, in 15 of them it was fully reversible, due to the possibility of aggressive antivasospastic treatment (hypervolaemia, induced arterial hypertension). The relatively worse results were obtained in patients with chronic arterial hypertension.

Adolescent

The value of different methods of treatment of brain abscess in the CT era.

67 cases of brain abscess were analyzed retrospectively. As 2 comatose patients died on admission before any treatment was started, the results are based on 65 treated patients. Different methods of treatment included: total removal in 36 patients, drainage in 14, aspiration in 6 and conservative treatment in 9. Management mortality was 18.5% and was almost not dependent on the method of treatment (except aspiration) being lowest in the drainage group. The mortality was significantly higher in patients with serious impairment of consciousness on admission. Follow-up examination after 1 to 11 years was performed in 47 out of 53 discharged patients and revealed in 25 of them (53%) full recovery. 10 additional cases (21%) are independent. The best early and long term results were obtained in patients by drainage and medical treatment. Chronic epilepsy developed in 34% of patients with supratentorial lesions. The risk of epilepsy was lowest in the group of patients treated by drainage. The authors present the opinion that removal of brain abscess is necessary only in exceptional cases.

Adolescent

Ruptured intracranial aneurysm associated with spontaneous occlusion of internal carotid artery. Experience with 5 cases.

Out of 921 patients diagnosed and treated for intracranial aneurysm in 5 cases (0.5%) the co-existence of ruptured aneurysm and occlusion of the internal carotid artery was found. 4 patients were treated surgically--aneurysm clipping--without serious post-operative complications and 6 months follow-up showed satisfactory results. In 4 of 5 cases the aneurysm was located on the anterior communicating artery (ACA); this fact may support the hypothesis concerning a possible role of enhanced blood flow in aneurysm formation and rupture. In cases with good collateral blood flow extra-/intracranial bypass before aneurysm occlusion seems not to be necessary. The risk of operation in those patients is not as high, as might be expected.

Adult

[Conservative treatment of intracranial hematomas and the dynamics of their resorption].

In 10 out of 63 patients with intracerebral haematomas treated conservatively the authors measured approximately the volume of haematomas by means of serial CT examinations during observation of their resorption. These were large and medium-size haematomas, from 20 to 70 ml in volume. The mean rate of resorption was from 0.7 to 1.0 ml daily. Gradual regression of mass effects was noted. All patients were on admission in a relatively good condition, conscious or only somnolent, with focal neurological signs. In some cases signs of increased intracranial pressure were present. Improvement of the general condition and neurological status was relatively rapid, even pronounced paresis and aphasia regressed in most cases. Two patients (3%) died of non-cerebral causes. It is believed that most intracerebral haematomas may be treated conservatively. The presence of mass effects, increased intracranial pressure or even a major neurological syndrome are not regarded as indications to operation if the state of consciousness is good and is not deteriorating. Even large and deeply situated haematomas may be resorbed without leaving a gross neurological deficit. A careful observation of the state of the patient, control CT investigations and the possibility of carrying out emergency operation in case of deterioration of the level of consciousness are indispensable for safe conservative treatment of these patients.

Adult

Pathological findings in suboccipital decompression in 63 patients with syringomyelia.

Out of 97 patients with syringomyelia treated surgically, in 63 of them suboccipital decompression was performed. Various kinds of congenital or early acquired abnormalities were found to be the possible cause of the disease. Simple Arnold-Chiari malformation was found in 29 patients. In next 16 cases the Arnold-Chiari malformation was accompanied by partial occlusion of the foramen of Magendie with tiny, translucid membrane, that covered lower 1/2 or 3/4 of the foramen. In another 9 cases of Arnold-Chiari malformation, foramen of Magendie was totally occluded with thick, grayish membrane. In 7 cases lowered cerebellar tonsils were firmly attached to the medulla and joined by adhesions between themselves. In 1 case total atresia of foramen of Magendie was present only. In 1 case no pathological changes were found. The above mentioned findings point out, that in practically all the cases of syringomyelia various kinds of gross pathology, that leads to difficulties in normal outflow of the CSF from the IVth ventricle to cisterns can be found. From that point of view the suboccipital decompression seems to be the most reasonable surgical procedure.

Cerebral Ventricles

Late results of the surgical treatment of syringomyelia.

97 patients with syringomyelia were treated surgically during the last 12 years. Only those patients in which the disease showed rapid progression in the last 1/2-1 year were operated. Of these 97 patients 54 were followed for 5 years or longer. 28 patients were treated by suboccipital decompression, 17 by terminal ventriculostomy, 4 by myelotomy and syringo-subarachnoid shunt; 5 had a combination of two procedures. Very good results were obtained in 12 patients (22%), satisfactory-in 31 (58%) and poor results-in 11 (20%). Very good results were more often achieved after suboccipital decompression, but each method had as well excellent as unsatisfactory results, and the number of the patients is too small as to allow statistically significant conclusions. It is almost impossible to predict the result of the surgical treatment in syringomyelia, but good results were obtained most often in young patients with relatively short duration of the disease. However, it is not the rule. Satisfactory results can even be obtained in older patients with long lasting disease and poor neurological status. The best method of surgical treatment is still under discussion.

Aging

Jerzy Choróbski.

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History, 20th Century