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Biomedical subjects

J Blahos

Publications and source records attributed to J Blahos.

At least 19 recordsLinked to original sources
PubMed1992

[Life style risk factors in the etiopathogenesis of osteoporosis and possibilities of prevention].

The prevalence of osteoporosis and its complications, in particular fractures of the femur, are rising and at present special attention is devoted to osteoporosis from the scientific, health and socio-economic aspect. The authors deal with factors of civilization which are involved in the aetiopathogenesis of osteoporosis and its complications and which can be influenced by preventive provisions. These factors which are part of the modern lifestyle comprise physical load, nutritional influences, the influence of toxic substances and drugs. As to nutritional factors the authors pay attention to an adequate calcium intake. They deal in detail also with aluminium intoxications. Attention is also drawn to the possible pathogenetic importance of stress and the authors contemplate on the inclusion of osteoporosis among diseases of civilization.

Calcium, Dietary↗
PubMed1992

[New views on the pathogenesis of osteoporosis].

The author points out new aspects on pathogenetic factors of osteoporosis and its complications. the character of these factors shows that osteoporosis may be considered as a "civilization disease". The incidence of osteoporosis in all civilized countries is increasing and there is a striking resemblance of factors involved in the pathogenesis of osteoporosis to factors involved in the pathogenesis of other "typical civilization diseases" as are cardiovascular diseases or cancer. In more detail are mentioned the roles of physical exercise, nutrition, drugs and various toxic factors.

Humans↗
PubMed1978

Effects of low calcium and low phosphorus diets on the duodenal absorption of calcium in betamethasone-treated chicks.

The effect of oral administration of betamethasone (25 microgram kg-1 day-1) on the duodenal absorption of calcium has been studied in chicks using the ligated loop technique in vivo. The chicks were fed normal calcium, normal phosphorus (NCaNP), low calcium, normal phosphorus (LCaNP) or normal calcium, low phosphorus (NCaLP) diets. Daily oral administration of betamethasone for 2-3 weeks markedly reduced the absorption of calcium in chicks fed the NCaNP diet, but did not significantly affect the adaptation in absorption when the NCaLP or LCaNP diets were fed for the same period of time. In one group of chicks, betamethasone was administered daily for 10 days before the birds were transferred to the NCaLP or LCaNP diets. Adaptation was again unaffected by betamethasone treatment. Administration of betamethasone caused a marked retardation in growth-rate, hypercalcaemia and an increased percentage of ash in the tibiae.

Animals↗
PubMed1976

The effect of calcitonin on glucose metabolism.

The authors have studied the effect of calcitonin on glucose metabolism. Ten healthy volunteers were investigated. Calcitonin administered intramuscularly in one single dose inhibited the physiological decrease of blood glucose levels during the forenoon fast. Salmon calcitonin administered in an intravenous infusion in the dose of 0.15 U MRC/kg of body weight impaired the glucose tolerance test with the increase of blood glucose levels. The greatest difference was in the 120th minute after the administration of 100 gm of glucose. Calcitonin failed to produce any significant inhibition of immunoreactive insulin release following the glucose stimulus. However, further studies will be necessary to show whether this lack of the inhibitory beta cytotropic action of calcitonin was due to the low dose of calcitonin.

Adult↗