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Biomedical subjects

J Bleistein

Publications and source records attributed to J Bleistein.

9 recordsLinked to original sources
PubMed1990

Exogenous coenzyme Q (coq) fails to increase coq in skeletal muscle of two patients with mitochondrial myopathies.

Recently, several studies were published on therapy with coenzyme Q (CoQ) in patients with mitochondrial myopathies without biochemically established muscular deficiency of CoQ. Two patients with mitochondrial myopathies presenting as oculocraniosomatic syndromes were treated with coenzyme Q (CoQ). The muscle biopsy of both patients showed ragged-red fibers and single muscle fibers without histochemical reaction for cytochrome c oxidase. Biochemical analysis revealed normal activities of the respiratory chain complexes in muscle and normal levels of CoQ in serum and muscle. After one year of treatment CoQ in serum of both patients had increased 1.4-fold and 2.0-fold, respectively. In muscle, however, there was no increase of CoQ in either patient. In both patients the activities of citrate synthase and of the respiratory chain complexes I + III and IV, and in 1 patient also of complex II + III, were lower in the second biopsy compared with the first biopsy. In both patients there was no improvement of maximal isometric muscle strength assessed by a quantitative electronic strain gauge. The exercise-induced pathological rise of lactate in 1 patient remained essentially unchanged during therapy. The data indicate that orally administered CoQ fails to increase total CoQ in muscle of patients with mitochondrial myopathies but without muscular CoQ deficiency.

Administration, Oral↗
PubMed1989

Partial deficiency of complexes I and IV of the mitochondrial respiratory chain in skeletal muscle of two patients with mitochondrial myopathy.

Respiratory chain enzymes were studied in isolated mitochondria of two patients with mitochondrial myopathy. Both patients had been suffering from chronic progressive external ophthalmoplegia and abnormal muscular fatigability since late childhood. One of the patients exhibited the complete triad of symptoms characteristic of Kearns-Sayre syndrome. Venous lactate levels at rest and during minimal exercise were increased in both patients. Histochemical examination of muscle revealed ragged red fibres and intermingled fibres negative for cytochrome c oxidase. Biochemical studies showed decreased activities of complex I and complex IV of the respiratory chain in both patients. Reduced minus oxidized spectra of mitochondrial cytochromes revealed a decreased content of cytochrome aa3 in only one patient, but a normal content in the other. A combined deficiency of complexes I and IV in muscle might either be due to a deficiency of a single subunit common to both complexes or to a coincidental deficiency of both complexes expressed either in the same or in different fibres.

Adult↗
PubMed1989

[EEG findings in cortisone psychoses--a retrospective study in 10 patients].

The EEG of 10 patients, suffering from cortisone induced transit syndromes according to H.H. Wieck were studied retrospectively. Four patients with mild forms of transit syndromes and acute onset (appearance of symptoms within one month) showed normal EEG. EEG-alterations (i.e. parenrhythms and aidiorhythms according to H. Penin) were found in 5 patients, suffering from a severe transit syndrome with peracute onset (appearance of symptoms within 7 days). Their EEG became normal after remission of this severe transit syndrome. EEG-alterations were not influenced by the administered cortisone dosage. No epileptic seizures nor epileptic patterns in EEG were seen while under cortisone treatment. The data indicate a good correlation between syndrom severity of cortisone induced transit syndromes and the appearance of pathological EEG-patterns.

Adult↗
PubMed1988

[Cortisone-induced psychoses].

The records of 15 patients with cortisone psychoses were studied retrospectively. We observed two types of these substance-induced mental disorders: 1. rapidly reversible organic psychoses with peracute onset and 2. cortisone-induced schizophrenic psychoses with prolonged remission and typical follow-up. Depressive moods, dysthymia, anxiety, psychomotor agitation or euphoric symptoms are features occurring in initial states or mild forms of transit syndromes. More severe forms of cortisone induced transit syndromes are dominated by delusions and hallucinations, whereas most severe transit syndromes are characterized by reversible dementia. Females were affected more frequent than males. 40% of our patients developed steroid psychoses after treatment with a daily dose of 5-20 mg prednisolone or its equivalent. Neither dosage nor duration of treatment influenced severity, onset or duration of this mental disorders. Neuroleptic treatment and dose reduction led in 87% of patients to remission within four weeks.

Adult↗
PubMed1986

[Neurological complications and therapy in herpesvirus diseases].

An overview on the diversity of neurologic complications of infections with different human herpes virus strains is given. Encephalitis, meningoencephalitis and the Guillain-Barré-syndrome are of major importance. Affection of single cranial nerves and mononeuropathies occur in a lesser frequency, while myelitis and isolated disturbances of the autonomic nervous system are rare complications. Therapeutically the application of acyclovir in herpes simplex and varicella zoster virus infections has given encouraging outlooks, whereas no convincing results exist with respect to cytomegalovirus and Epstein-Barr virus infections.

Antiviral Agents↗
PubMed1985

[Paroxysmal phenomena in multiple sclerosis].

The different types and common features of paroxysmal attacks are illustrated by three case reports. The main cause for these attacks is multiple sclerosis, but the mechanism is still unknown: ephaptic activation of demyelinated neurons is discussed. "Anticonvulsive therapy" leads to cessation of the attacks.

Adult↗