PubMed Health⌕ Search

Biomedical subjects

J Boné

Publications and source records attributed to J Boné.

29 records · Page 2Linked to original sources
PubMed1975

Urea production related to intraperitoneal inflammation.

To eluicdate a possible connection between the amount of urea production and degree of intraperitoneal complication 24 hour urea production was studied in patients having undergone appendectomy. The base material consisting of 60 patients with an uncomplicated postoperative course was divided into three groups: 1) 20 patients with a normal appendix without any infection, 2) 20 patients with acute appendicitis without perforation, and 3) 20 patients with acute appendicitis with perforation and varying degrees of peritonitis. Twenty-four hour urea production was determined from the second to seventh postoperative day. A significant difference in postoperative urea production was found between the three groups mentioned, the patients in group 3 had the highest and the patients in group 1 the lowest urea production. Further, all three groups showed a gradual, significant decrease in urea production from second to seventh postoperative day. Two patients with intraperitoneal complications after appendectomy had a significantly increased urea production.

Abscess↗
PubMed1975

Parietal cell vagotomy in dogs. Influence on heidenhain pouch acid secretion, serum gastrin concentration, gastric emptying and motility.

No change was observed in fasting Heidenhain pouch (HP) acid secretion and fasting serum gastrin concentration following parietal cell vagotomy (PCV) in six dogs whereas significant increase in food-stimulated pouch secretion and serum gastrin concentration was observed. The increase in pouch secretion after PCV took place mainly in the first 2 h after meal. The maximum serum gastrin concentration was reached at 15 min after feeding before as well as after PCV. Maximum in HP secretion was reached later, at 120 min before and at 90 min after surgery. Gastric emptying studies, using a food-barium meal, showed a slight decrease in the emptying rate after PCV in two dogs, while it was unchanged in the others. Cineradiography showed an unaffected antral motility in all dogs after PCV.

Animals↗
PubMed1975

Serum gastrin concentration before and after parietal cell vagotomy in man and dog.

Serum gastrin concentrations were measured during fasting and after feeding in duodenal ulcer patients and in dogs before and after parietal cell vagotomy (PCV). Postoperatively, fasting serum gastrin concentrations increased significantly in man and insignificantly higher in dog. After feeding, serum gastrin reached higher values postoperatively in both man and dog. The percentage rise in food-stimulated serum gastrin after PCV was higher in dog than in man.

Adult↗
PubMedDate not supplied

Evaluation of paediatric tolerance to an extract of Alternaria alternata under two treatment regimes. A multicentre study.

In order to evaluate the efficacy and safety of an extract of Alternaria alternata in a paediatric population, a two phase study plan has been elaborated that in the first place consists of a retrospective analysis of tolerance under the standard treatment regimes used by the clinical groups involved. This was achieved by analysing the records of 94 patients that have been treated with this extract, these being consecutive patients included at 7 clinics over a period of 6 months. Two regimes were used: a conventional short regime of 7 doses and a cluster regime. Under neither of these two regimes were any serious reactions registered. The percentage of local reactions was significantly greater using the short conventional regime than with the cluster regime (1.9% and 0.4% respectively, p = .035). In contrast, no significant differences were observed with respect to the systemic reactions (0.5% and 1.2%), these percentages also being similar to those registered with other extracts in which identical regimes have been used. In conclusion, we can confirm that a very satisfactory tolerance profile was observed, with the advantage that through using shorter regimes than the conventional regime of 13 doses, a considerable saving is made both in the number of visits and the doses necessary to reach the maintenance dose.

Adolescent↗