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Biomedical subjects

J Bonte

Publications and source records attributed to J Bonte.

70 records · Page 4Linked to original sources
PubMedDate not supplied

Vaginal cytologic evaluation as a practical link between hormone blood levels and tumor hormone dependency in exclusive medroxyprogesterone treatment of recurrent or metastatic endometrial adenocarcinoma.

In one hundred patients treated by means of one gram medroxyprogesterone a week for disseminated or recurrent endometrial adenocarcinoma, vaginal cytohormonal evaluation seemed to be an important predictive factor of hormone dependency and tumoral responsiveness to progestational therapy. Almost all 51 patients, representing the responsive group, revealed an evident drop of the Karyopyknotic Index and a complete shift to the left of the Maturation Index. Both cytohormonal and tumoral response to medroxyprogesterone seemed directly related to estrogen-progestogen interaction on a cellular level. The striking LH response in the responsive group has previously not been integrated in this mechanism of action.

Adenocarcinoma↗
PubMedDate not supplied

Cytotoxic effects of müllerian inhibiting substance (MIS)?

To determine whether Müllerian Inhibiting Substance (MIS) is the factor responsible for the cytotoxic effects of testicular preparations on gynecological cancers, homogenates of bovine fetal testes were fractionated by Sephadex G 200 chromatography and their cytotoxic effects tested on a Müllerian-derived endometrial cancer cell line (AN3-CA), an ovarian carcinoma cell line (CAOV 3) and on a breast cancer cell line (MCF 7). No difference in cytotoxicity was found between Müllerian and non-Müllerian derived human cancer cells. Cytotoxicity and MIS activity were found in different fractions on Sephadex G 200 gel chromatography.

Anti-Mullerian Hormone↗
PubMedDate not supplied

Influence of practice on the biochemical analysis of steroid receptors in human breast cancer.

The value of experience and practice in the routine biochemical analysis of steroid receptors was studied in 2576 different primary breast cancer specimens over five consecutive years. The positivity rate (beyond 3 fm/protein) and the measured concentrations of the steroid receptors increase. The positivity rate and average steroid receptor concentration of the samples immediately frozen is significantly higher compared to the overall sample population. It is concluded that the handling of the specimen before freezing and the experience of the technician play an important role in the routine biochemical analysis of steroid receptors.

Breast Neoplasms↗
PubMedDate not supplied

Independent regulation of growth and steroid receptors in uterus and mammary tumors of rats.

Anti-estrogens and progestagens are synergistically active in the treatment of hormone dependent tumors. The combined action of both compounds in daily treatment schedules are analyzed in rat uterus and in DMBA- induced rat mammary tumors. Tamoxifen in contrast to estradiol does not significantly affect tissue growth, while PgR induction is considerably stimulated by Tamoxifen. It is suggested that the "estrogenic effects" of Tamoxifen and estradiol are separately modulated. When given in sequential combination with anti-estrogens, the anti-tumor response of progestagens is enhanced. Combinations of hormonal treatment based on careful analysis of the regulation processes at target cell level may greatly improve results of anti-tumor therapy.

9,10-Dimethyl-1,2-benzanthracene↗
PubMedDate not supplied

[Diagnostic value of breast cytology (author's transl)].

The comparison between clinical examination, mammography, thermography and fine needle aspiration cytology shows the usefulness of cytology in differential diagnosis of benign and malignant breast tumours. The cytology shows the real nature of benign suspicious and malignant mammographic and thermographic results. Specially in the younger patients cytology identifies early tissue changes, invisible on mammography. Application of the TNM classification shows TOT1 T2 tumours 72% of the material, with 90% positive cytologic results.

Adult↗
PubMedDate not supplied

Effects of daily anti-estrogen treatment on uterine growth and progesterone receptor concentrations in adult rat uterus.

The effects of daily Tamoxifen treatment on adult rat uterus weight depend on the degree of estrogenic impregnation of the animal. In intact animals, Tamoxifen caused a decrease of the uterine weight. A weight increase was observed, after castration, which was dose-dependent without reaching saturation even with 500 micrograms of Tamoxifen per day. This uterine weight increase, reaching its peak during the first 24 h after the initial Tamoxifen application, is attributable to water retention. The uterine progesterone receptor (PgR) concentrations are stimulated by daily antiestrogen treatment of intact and castrated animals. This increase in the PgR levels is initially dose-dependent up to 10 micrograms of Tamoxifen per day reaching maximal levels after 4 days of treatment. The results indicate that growth and PgR induction in adult rat uterus are essentially controlled by independent mechanisms, constituting the biological basis of the synergistic effects of anti-estrogens and progestagens.

Animals↗
PubMedDate not supplied

Adriamycin, cyclophosphamide and vindesine (ACV) versus mitoxantrone, cyclophosphamide and vindesine (NCV) in advanced breast cancer.

The choice of chemotherapy for advanced breast cancer patients is based on both response rates and anticipated side effects. Two polychemotherapy regimens, ACV and NCV, were compared in an open study with 90 patients of whom 69 were evaluable both for efficacy and toxicity. Both ACV and NCV are active in metastatic breast cancer. ACV leads to more remissions in a relatively short time. NCV treatment results in a larger proportion of stable diseases. ACV causes more important alopecia, nausea and vomiting. NCV gives more anemia. The characteristics of both treatment results give the oncologist the opportunity to choose in particular clinical situations.

Adult↗
PubMedDate not supplied

Effects of sodium ascorbate (vitamin C) and 2-methyl-1,4-naphthoquinone (vitamin K3) treatment on human tumor cell growth in vitro. II. Synergism with combined chemotherapy action.

The growth inhibitory effects of a combined application of sodium ascorbate (Vitamin C) and 2-methyl-1,4-naphthoquinone (Vitamin K3) together with various chemotherapeutic agents has been examined on in vitro cultured human endometrial adenocarcinoma (AN3CA) cells. Combined vitamin treatment and chemotherapy in well defined conditions of cell confluence and at the dose levels applied result in a synergistic effect on growth inhibition. The combined vitamins when reaching their own synergistic cytotoxicity levels frequently obscure the additional synergistic effects attributable to the chemotherapeutic agents. Apart from the specific cytotoxic characteristics of the chemotherapeutic drugs examined, the formation of reactive oxygen radicals during treatment, possibly accentuated by less defined secondary mechanisms, appears essentially responsible for the observed stimulated cytotoxicity.

Adenocarcinoma↗