PubMed Health⌕ Search

Biomedical subjects

J Booth

Publications and source records attributed to J Booth.

107 records · Page 6Linked to original sources
PubMed1966

Acetyl transfer in arylamine metabolism.

1. N-Hydroxyacetamidoaryl compounds (hydroxamic acids) are metabolites of arylamides, and an enzyme that transfers the acetyl group from these derivatives to arylamines has been found in rat tissues. The reaction products were identified by thin-layer chromatography and a spectrophotometric method, with 4-amino-azobenzene as acetyl acceptor, was used to measure enzyme activity. 2. The acetyltransferase was in the soluble fraction of rat liver, required a thiol for maximum activity and had a pH optimum between 6.0 and 7.5. 3. The soluble fractions of various rat tissues showed decreasing activity in the following order: liver, adrenal, kidney, lung, spleen, testis, heart; brain was inactive. 4. With the exception of aniline and aniline derivatives all the arylamines tested were effective as acetyl acceptors but aromatic compounds with side-chain amino groups were inactive. 5. The N-hydroxyacetamido derivatives of 2-naphthylamine, 4-amino-biphenyl and 2-aminofluorene were active acetyl donors but N-hydroxyacetanilide showed only slight activity. Acetyl-CoA was not a donor. 6. Some properties of the enzyme are compared with those of other acetyltransferases.

Acetates↗
PubMedDate not supplied

MRI investigation of hydration and heterogeneous degradation of aliphatic polyesters derived from lactic and glycolic acids: a controlled drug delivery device.

Magnetic Resonance Imaging experiments have been used to investigate the degradation of drug-loaded poly(glycolic lactic acid) (PGLA) 50:50 cylinders. Spatial variation in the rate of degradation throughout the polymer cross-section has been observed non-invasively using quantitative imaging of penetrant concentration, T(2) and self-diffusion coefficient. This spatial variation in the rate of degradation was attributed to the quicker degradation in the inner region of the sample due to autocatalysis by carboxyl end groups generated upon ester bond cleavage.

Catalysis↗
PubMedDate not supplied

Advantages of primary nursing in geriatric day hospitals.

This article presents a rationale for the introduction of primary nursing as the most suitable method of organisation in geriatric day hospitals. Working conditions, the status of the nurse within the multidisciplinary team and the opportunities afforded by primary nursing for enhancing the nurse-patient relationship are examined.

Aged↗
PubMedDate not supplied

New degrees of prejudice.

Explore the source record for details and available documents.

Education, Nursing, Baccalaureate↗
PubMedDate not supplied

The study of nursing intervention in practice (SNIP).

The creation of a new role for an advanced nurse practitioner in cardiovascular medicine is being evaluated in a prospective randomised controlled trial--the study of nursing intervention in practice (SNIP).

Ambulatory Surgical Procedures↗
PubMedDate not supplied

Travellers' checks.

Explore the source record for details and available documents.

Consultants↗
PubMedDate not supplied

Deliberate self harm: the hidden population.

Population-based epidemiological surveys of deliberate self harm (DSH) exclude homeless people and do not represent them in their conclusions. However, DSH in the homeless is commonly seen in inner city hospitals and the homeless are probably at higher risk of eventual suicide. We examined the demographic characteristics of all patients who presented to an inner London hospital after an episode of DSH over a period of three years and found that 15% of patients were of no fixed abode. Alternative methods of studying DSH need to be explored if suicide is to be prevented in this group of people.

Adolescent↗
PubMedDate not supplied

Home and dry.

Explore the source record for details and available documents.

Aged↗