Biomedical subjects
Publications and source records attributed to J Borbujo.
We report a case of multiple cylindromas with a linear arrangement on the lower right extremity. The patient had more than 100 tumors, but the scalp was spared. Some tumors showed overlapping features with eccrine spiradenoma. We believe this is the first report of multiple linear cylindromas.
1. Dose-response curves for noradrenaline, phenylephrine and clonidine were determined isometrically in 2-mm cylindrical segments from human skin arteries at 24 degrees C and compared to those previously reported at 37 degrees C. 2. Noradrenaline (3 x 10(-10)-3 x 10(-4) M) induced dose-dependent contraction and the sensitivity was increased during cooling. Phentolamine (10(-6) M), prazosin (10(-6) M) or yohimbine (10(-6) M) produced a higher rightward shift of the control curve for noradrenaline during cooling. 3. Phenylephrine (10(-11)-3 x 10(-4) M) and clonidine (10(-11)-10(-6) M) caused dose-dependent contraction and the sensitivity of the arteries was augmented at 24 degrees C. 4. The arteries also showed a lower maximal contraction to the adrenergic agonists used and KCl (50 mM) during cooling. 5. The results suggest that cooling: (a) increases sensitivity of postjunctional alpha 1- and alpha 2-adrenoceptors in human skin arteries and (b) depresses contractility of these arteries to alpha-adrenergic stimulation and direct activation of vascular smooth muscle.
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Amyloidosis maculosa is a clinical entity with low incidence factor in our medium, which basically affects middle-aged women. The lesion is characterised by the presence of poorly defined, hyperpigmented, brownish or greyish maculae that converge and focus basically on the upper back and shoulders, usually accompanied by pruritus. Three patients were erroneously catalogued for years as having pityriasis versicolor. Two of these patients presented a typical clinical amyloidosis maculosa, and the third presented a less common manifestation of the disease: a single, well-defined lesion in the subscapular region. We believe that the approach to the diagnosis of pityriasis versicolor with hyperpigmented lesions that do not respond to specific treatment should be revised. Although amyloidosis maculosa has a low incidence in our medium, it is an entity which should not be discarded in these cases.