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Biomedical subjects

J Borquez

Publications and source records attributed to J Borquez.

2 recordsLinked to original sources

Diterpenoids from Haplopappus rigidus.

Fractionation of the aerial parts of Haplopappus rigidus Phil., directed by the brine shrimp lethality test (BST), has led to the isolation of two new diterpenoids, rigidusol and deacetylrigidusol. Their structures were established as 13-hydroxy-18-acetoxy-cis-cleroda-3,14-diene (8betaH, 10betaH, 19beta, 20alpha form) and 13,18-dihydroxy-cis-cleroda-3,14-diene (8betaH, 10betaH, 19beta, 20alpha form), respectively. Rigidusol exhibit moderate cytotoxic activity against human breast adenocarcinoma cell line MCF-7. Their structures were established by spectral data, in particular using 2D NMR spectroscopy (DEPT, DQF-COSY, HMQC and HMBC).

Asteraceae↗

Unemployment and work interruption among African American single mothers: effects on parenting and adolescent socioemotional functioning.

Using interview data from a sample of 241 single African American mothers and their seventh- and eighth-grade children, this study tests a model of how 2 economic stressors, maternal unemployment and work interruption, influence adolescent socioemotional functioning. In general, these economic stressors affected adolescent socioemotional functioning indirectly, rather than directly, through their impact on mothers' psychological functioning and, in turn, parenting behavior and mother-child relations. Current unemployment, but not past work interruption, had a direct effect on depressive symptomatology in mothers. As expected, depressive symptomatology in mothers predicted more frequent maternal punishment of adolescents, and this relation was fully mediated by mothers' negative perceptions of the maternal role. More frequent maternal punishment was associated with increased cognitive distress and depressive symptoms in adolescents, and consistent with predictions, these relations were partially mediated by adolescents' perceptions of the quality of relations with their mothers. Increased availability of instrumental support, as perceived by mothers, predicted fewer depressive symptoms in mothers, less punishment of adolescents, and less negativity about the maternal role. Both economic stressors were associated with higher levels of perceived financial strain in mothers, which in turn predicted adolescents' perceptions of economic hardship. Adolescents who perceived their families as experiencing more severe economic hardship reported higher anxiety, more cognitive distress, and lower self-esteem.

Adolescent↗