Biomedical subjects

J Bosak

Publications and source records attributed to J Bosak.

3 recordsLinked to original sources

PubMed1984

A study of mental health administrators and systems utilizing a four-part rural/urban taxonomy.

A study of administrators working in public-sector community-level mental health systems was undertaken. Three hundred and fourteen managers representing 109 systems in both urban and rural settings were interviewed, with 91 percent providing completed questionnaires. Multiple discriminant analyses indicated significant differences in perception of ruralness; personal, job, and system characteristics; and nonwork dimensions. Administrators differed in what they did on the job, not in responses (e.g., turnover, stress) to their work. The rural manager seems more a generalist, but other stereotypes of the nature of rural mental health management and managers were contraindicated. Implications of the data and further research are discussed.

Community Mental Health Services↗

PubMed1980

Single-isotope enzymatic derivative method for measuring catecholamines in human plasma.

The radioenzymatic determination of plasma catecholamines with a modification of the method of da Prada & Zürcher ((1976), Life Sci 19, 1161-1174) is described. The several reaction steps were optimized with respect to the quantities of substrate and enzyme, and reaction time. There were particular methodological difficulties concerning the blanks, which were determined by using sodium metaperiodate-oxidized plasma. The reliability criteria of the method were determined. Coefficients of variation between 3.4 and 8.6% were found for the intra-assay variability of 10 pg of norepinephrine and 3 pg of epinephrine or dopamine, resp. The recoveries o the three catecholamines ranged from 88-93%. The detection limits were calculated from the standard deviation of the blanks and amounted to 12 ng/l (norepinephrine), 6 ng/l (dopamine) and 3 ng/l (epinephrine). The method was used for the analysis of plasma samples from patients. In a further investigation we examined the stability of plasma catecholamines stored at different temperatures. It was found that samples can be stored for 1-2 hours at room temperature and for several weeks at -27 degrees C without losses in catecholamine content.

Animals↗

PubMed1979

Platelet turnover studies associated with left ventricular assist device (LVAD) implantation.

Calves given LVADs have been studied to determine changes in platelet turnover induced by the device and modified by time and anticoagulants. Passivation with time occurs but is surprisingly incomplete even one month later and despite coumadin, aspirin and dipyridamole. Without these drugs, enhanced platelet turnover and local thrombus formation on the device is exaggerated. Sequential platelet turnover studies may be useful to quantitate, monitor and/or predict thromboembolic events.

Animals↗