[In vitro dissolution test: evaluation criterion for prolonged release dosage forms vincamine example (author's transl)].
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Biomedical subjects
Publications and source records attributed to J Boucherat.
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This study consisted of a comparison of the release rates of six commercial brands of prolonged-release vincamine. The pH of the dissolution medium was found to be highly significant. Due to the low solubility of vincamine in media close to the neutral point, all of the preparations tested, with the exception of one, showed highly variable release curves under the three pH conditions chosen.
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