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Biomedical subjects

J Bourne

Publications and source records attributed to J Bourne.

16 recordsLinked to original sources
PubMed1987

Clinical hypersensitivity to specific aerosol challenge in parenterally immunized calves.

This paper reports an experiment designed to demonstrate that the calf lung can be sensitized to a specific respirable challenge following parenteral immunization with a nonliving antigen (human serum albumin). The possibility that immune-mediated injury could subsequently interfere with nonspecific mucosal defenses was also investigated by infecting calves with Pasteurella haemolytica after the antigen challenge and assessing pulmonary clearance of the organism. The results indicated that specific aerosol challenge produces reversible signs of respiratory hypersensitivity and that persistence of incidental infection in the upper respiratory tract is potentiated. Since the calves were sensitized by an immunization regime which imitated conventional vaccination, this study highlights the potential dangers of inactivated parenteral respiratory vaccines.

Aerosols↗
PubMed1977

The nature of the local immune system of the bovine mammary gland.

The origin of the immunoglobulins of bovine colostrum and milk were examined by using radiolabeled protein. Colostrum was found to consist mainly of immunoglobulin derived from serum, although there was some local synthesis. In lactation the immunoglobulins of milk were almost entirely serum derived. The local immune system was very inactive but could be stimulated to activity by local immunization. The immunoglobulin profiles of the secretion from the stimulated gland were still relatively deficient in IgA compared to other species, notably the pig.

Animals↗