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Biomedical subjects

J Boutin

Publications and source records attributed to J Boutin.

13 recordsLinked to original sources

Patients' preference regarding portable pumps.

The growing number of home parenteral nutrition patients has encouraged the development of portable infusion pumps. The authors found that the individual who meets the criteria for home therapy is also the same individual who welcomes independence. The portable pump further enabled these individuals, who have already undergone a major lifestyle change, to achieve the desired independence. Twenty-three home parenteral nutrition patients were surveyed regarding pump satisfaction and operation. The distinct psychological advantage provided was the final motivating factor.

Humans

[Glomerular disease associated with myelofibrosis (author's transl)].

The authors report the case of a 46 year-old patient presenting with membranous-proliferative glomerular disease, megakaryocytes present in the glomerular capillaries, evolving concomitantly with myelofibrosis. There are two possible explanations for this unusual association: the glomerular disease and the myelofibrosis may both result from the same etiologic and pathogenic factor, or the glomerular disease may be the consequence, thrombocytosis existing, of platelet activation, either direct or after deposition of immune complexes. The formation of immune complexes after antigenic stimulation in myelofibrosis is theoretically compatible with immunitary anomalies found in the evolution of this disorder as described in the literature.

Humans

[Renal lesions in myelofibrosis (author's transl)].

In 26 cases of myelofibrosis, the authors investigated for possible renal impairment that can be appraised from the usual clinical, laboratory, and roentgenographic signs. No anomalies were demonstrated in 12 of these cases. In 14 (or 53%) of the patients, some anomaly was discovered : essentially proteinuria with minor alteration of renal function, but also, two cases of poorly functioning left kidney evidenced on intravenous urograms, one case of acute anuric renal failure connected with hyperuricemia, one case of hypokalemic tubulo-interstitial nephritis, and one case of glomerulonephritis with, nephrotic syndrome. This study, when compared to the literature, indicates that besides nephropathy specific to myelofibrosis and attributed to myeloid metaplasia in the kidney, serious consideration must be given to lesions due to (1) compression of the left kidney by the enlarged spleen, (2) urate precipitation in the urinary passages, and (3) a possible glomerular disorder whose mechanism remains undefined.

Adult

[Hyperacute periarteritis nodosa complicating Basedow's disease].

The symptoms and the evolution of necrotizing vasculitis vary greatly. The authors illustrate the case of an 18 year old patient with a history of frequent allergic manifestations (urticaria and others) who was found to have, in septembre 1975, a typical case of Grave's disease. During the following 2 months she was treated with an iodide derivative. One year later the clinical signs increased to the point where a treatment associating lugol, carbamizole and propanolol was deemed necessary. Less than 2 months later there developed a polyvisceral disease with oscillating fever, polyarthralgia and necrotizing vasculitis. The plurivisceral nature of the illness was further illustrated by the presence of a hyperreflexia, a glomerulopathy and retinal exsudats. A muscle biopsy revealed the necrotizing vasculitis with granulomas typical of periarteritis nodosa. Cardiac, neurologic and renal complications were responsable for a rapid down-hill course and despite corticoïdes and immunosuppresive drugs, the patient died after a few weeks of treatment. That periarteritis nodosa should complicate the evolution of Grave's disease suggests a connection between the two, very probably immunologic in nature. The role of drugs capable of inducing vasculitis must be explored, especially the iodide derivatives, the antithyroïd medications or their association. Such cases, even though they may be rare, should incite special care in the prescription of antithyroïd drugs in the allergic patient.

Acute Disease