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Biomedical subjects

J Brömsen

Publications and source records attributed to J Brömsen.

4 recordsLinked to original sources
PubMed2006

[Prevention of thromboembolism in patients with atrial fibrillation].

Provided that account is taken of the criteria discussed in the present article, there is no doubt about the therapeutic benefits of effective anticoagulation in patients with chronic atrial fibrillation. Indeed, it is to be expected that the previously valid therapeutic guidelines are more likely to be expanded to reduce feared thromboembolic complications to a minimum, as is exemplified by the recommendation that the application of anticoagulation treatment with vitamin K antagonists should be continued over the longer term, that is, after the restoration of sinus rhythm. Furthermore, there is hope that effective drugs with a calculable (level of) safety and simplicity of administration may soon become available.

Administration, Oral↗
PubMed2005

[Cardiac resynchronization therapy].

Severe cardiac insufficiency with a clearly diminished contraction of the left ventricle is often accompanied by a pronounced left bundle branch block in the EKG. The early and late activated sides of the ventricular walls contract asynchronously, further decreasing the cardiac output. Resynchronization can be achieved through a biventricular pacemaker, which simultaneously stimulates the early and late sides of the ventricular walls. In addition to the electrode usually placed in the tip of the right ventricle, a second electrode is placed on the lateral wall of the left ventricle. This normally leads to an immediate small increase in the blood pressure and to an increased functional capacity. For patients with asynchrony of the left ventricle, an improvement of the cardiac insufficiency by approximately a half of an NYHA class and a decrease in the yearly mortality by 4% has been documented.

Algorithms↗
PubMed2005

[Effect of CRT on morbidity and mortality].

Patients with chronic heart failure who show a left ventricular ejection fraction < or =35% and remain in NYHA class III or IV despite optimal pharmacologic treatment show less morbidity and mortality on cardiac resynchronization therapy (CRT) if the left ventricle shows asynchrony. Although only one study has shown a significant reduction of mortality about 4% less deaths per year in the first two years can be resumed. Procedure related mortality is less than 1%. By improving on average one NYHA class 10-20% less patients experience hospitalization due to heart failure in the first two years after implantation of a CRT device. Patients who are hospitalized despite CRT have on average a hospital stay below 5 days. At least 10% of patients are currently suffering surgical revisions due to infections, dislocations and high pacing thresholds of the left ventricular lead. If costs saved by less hospitalization can finance costs of CRT or even exceed the costs of CRT remains unknown.

Cardiac Pacing, Artificial↗