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Biomedical subjects

J Brenner

Publications and source records attributed to J Brenner.

81 records · Page 5Linked to original sources
PubMedDate not supplied

Characterization and clinical relevance of a new complement-fixing antibody--anti-M8--in patients with primary biliary cirrhosis.

A new complement-fixing antimitochondrial antibody--anti-M8--was detected in patients with primary biliary cirrhosis. Anti-M8 was only found in association with anti-M2, however, not all anti-M2 positive patients had anti-M8. Thus, among 66 anti-M2 positive patients, 29 were also positive for anti-M8, whereas sera from patients who had the complement-fixing anti-M2 and anti-M4 antibodies in parallel always strongly reacted with the M8 antigen. This group was previously described as mixed form. The M8 antigen was isolated either from human liver mitochondria or pig kidney microsomes and could be clearly distinguished from the M4 antigen. In contrast to M4, M8 was trypsin sensitive and banded at sucrose densities from 1.16 to 1.24, while M4 was found at densities from 1.08 to 1.14. Like M4, the M8 antigen also co-purified with outer mitochondrial membranes. Fifty-three patients with primary biliary cirrhosis have been followed over a period of up to 16 years and were classified according to their complement-fixing antimitochondrial antibody profile. At the time of the first diagnosis, 95% of 31 patients being anti-M2 positive, but anti-M8 negative (antimitochondrial antibody Profile I) were in Stage I or II. In contrast, only 61% of 13 patients being anti-M2 and anti-M8 positive (antimitochondrial antibody Profile II) and 44% of 9 patients with anti-M2, anti-M8 and anti-M4 in parallel (antimitochondrial antibody Profile III) belonged to Stage I or II.(ABSTRACT TRUNCATED AT 250 WORDS)

Antibodies↗
PubMedDate not supplied

Enhanced antibody response in cattle against Leptospira hardjo by intradermal vaccination.

A commercial killed Leptospira hardjo vaccine (with adjuvant) and non-adjuvanted preparation of the same vaccine were used in comparison of the effectiveness of the intradermal (i.d.) and subcutaneous (s.c.) routes for these vaccines. The tests were conducted in 50 females aged 6-14 months. After the first vaccination, both types of vaccine elicited a very poor antibody response by both routes of vaccination. However, after booster vaccination, the commercial vaccine (with adjuvant) elicited a remarkable immune response which was twice as high by i.d. compared with s.c. vaccination. No local or general adverse reactions were observed after i.d. vaccination with the adjuvanted commercial vaccine (potassium aluminium sulphate).

Administration, Cutaneous↗
PubMedDate not supplied

Cerebral aspergillosis: MR imaging and histopathologic correlation.

The authors report a case of intracranial aspergillosis secondary to immunosuppression. Signal intensity changes in the lesion on brain MR are compared with gross and histopathologic findings at autopsy. A peripheral ring of low signal intensity relates to a dense population of Aspergillus hyphal elements and small areas of hemorrhage. CT findings are included for comparison.

Adult↗
PubMedDate not supplied

Recognition of the aberrant right subclavian artery on cervical spine MR.

Neuroradiologists performing cervical spine MR scans are reminded that an aberrant right subclavian artery is detectable on sagittal cervical spine views. This review of 335 consecutive patients revealed two such anomalies for a prevalence of 0.6%, which compares favorably with the published range of occurrences in the literature (0.5 to 2%).

Adolescent↗
PubMedDate not supplied

Hemorrhagic necrosis and vascular injury in carbon monoxide poisoning: MR demonstration.

MR imaging of a patient 3-years status post-carbon monoxide (CO) poisoning revealed areas of abnormal signal bilaterally in the region of the globus pallidus that had shorter T1 characteristics and longer T2 characteristics than cerebrospinal fluid, probably representing methemoglobin, and that is surrounded by a rim of decreased signal on T2-weighted images, felt to represent hemosiderin. This case demonstrates characteristic findings on MR imaging of CO poisoning, as well as observations that suggest prior focal hemorrhage. Typical findings, neuropathology, and the role of vascular injury and prognosis are discussed.

Adult↗