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J Brines

Publications and source records attributed to J Brines.

14 recordsLinked to original sources
PubMed1990

Serological markers and celiac disease: a new diagnostic approach?

We analyze the diagnostic efficacy of two celiac disease serological markers: anti-gliadin (IgA and IgG class) and anti-endomysium IgA-class (EmA-IgA) antibodies applied to 336 serum samples from celiac patients on both gluten-challenge and gluten-free diets, and a control group. The anti-gliadin and anti-endomysium antibodies levels were significantly higher among the gluten-consuming celiac patients than in the other groups. The greatest efficacy in diagnosing celiac disease was achieved in the Ema-IgA class test. The IgA-class anti-gliadin antibodies proved to be more specific, with a higher positive test predictive value than the IgG-class anti-gliadin antibodies, whereas the latter proved to be more sensitive, with a higher negative test predictive value than those of the IgA-class anti-gliadin antibodies. Our results also demonstrate that the simultaneous assessment of anti-gliadin IgA- and IgG-class antibodies constitutes a valid test in selecting patients suspected of having celiac disease. In turn the EmA-IgA antibodies constitute a confirmative test for indication of an intestinal biopsy.

Adolescent↗
PubMed1986

[Serum DNA of hepatitis B virus in children with chronic infection].

Viral replication has been studied in 44 children with chronic infection induced by hepatitis B virus (HBV) investigating HBV-DNA by molecular hydridization technique, correlating its presence with immunological markers and activity of liver disease. HBV-DNA presence is correlated to HBe Ag detection, but this antigen was also found in absence of viral DNA (7 cases of 31). That can mean viral replication diminishes or disappears before the seroconversion. No differences were found in viral replication phases as for clinical manifestations in children. In presence of viral DNA, serum aminotransferases were higher (p less than 0,005) and active hepatic lesions more frequent. Therefore, more cytolysis an inflammation are found in presence of circulating virus. On the other, more developed lesions (inactive cirrhosis and hepatocellular carcinoma) have been found in viral replication absence.

Adolescent↗
PubMed1978

[A short loading acidificacion test with calcium chloride in infants (author's transl)].

The response of blood and kidney to orally administered CaCl2 (4.1 mEq. X Kg.) in a short acid loading was compared to that attained with standard agent NH4Cl (3.9 mEq. X Kg) in two groups of normal infants through a 6 hrs. period. Plasma pH and bicarbonate decreased significantly. Minimum urine pH was 5.0 o lesser in all infants. Decrease of urine pH was greater to CaCl2 than to NH4Cl group but the net hydrogen ion excretion by the kidney was minor. Accordingly this experience CaCl2 can replace NH4Cl as acidifying substance in a short acid loading test. Indication will be diffuse hepatic lesions rendering dangerous NH4Cl administration.

Acidosis, Renal Tubular↗
PubMed1977

Fosfomycin in infantile acute gastroenteritis.

A clinical test was carried out on 83 children suffering from infectious diarrhoeal processes who were treated with fosfomycin with the oral and paranteral route. Coproculture was carried out in all the children before the beginning of treatment and in 51 of them it was repeated at the end of treatment. Antibiograms were made on the isolated germs and their MIC to fosfomycin studied. Tolerance and secondary effects of the medicament were also studied. The study was considered insufficient in 13 patients so that the evaluation was based on 70, making 4 failures and 60 clinical cures. Administration of fosfomycin causes the eradication of serotypeable E. coli and is followed by an increase in the number of Proteus sp. and Klebsiella/Enterobacter. The sensitivity of the faecal flora to fosfomycin has been very high, except for the strains of Proteus sp. and Klebsiella/Enterobacter. The accumulative percentage of the MIC to fosfomycin of all the strains isolated shows that more than 75% of them are inhibited at concentrations under 32 mug/ml. Tolerance was good and no secondary effects were observed except for the sporadic rise in the SGPT of the children.

Acute Disease↗
PubMed1977

[Problem oriented pediatric record (author's transl)].

The object of this paper is the presentation of the problem griented medical record now in use at the Department of Pediatrics of the Faculty of Medicine of the University of Valencia. The main documents of this medical record (problem list, discharge summary, anamnesis and physical examination summary, and medical record summary) are given describing the characteristics of format and the rules for its completion. The relationships between the main documents are shown.

Child↗
PubMed1976

[Pulmonary disease during mtx therapy in a.l.l. (author's transl)].

Authors describe three cases of pulmonary disease showed in three children with acute lymphoblastic leukemia during maintenance therapy with Methotrexate (MTX) (Dose: 30 mg/sm/W). The initial symptom occurs in the lapse between 40 and 135 days within the first MTX maintenance period and in 35 days in the second maintenance period. Leukopenia with eosinophilia (192-264 eosinophils/mm3) occurs in case 1. The maintenance of the MTX therapy in this case ends with death of the patient. Radiological studies show basal bilateral pulmonary infiltrations, with pleural involvement in one case. Authors insist in the drug (MTX) suppression as main therapy and agree with the opinion of some authors concerning to the 31 cases previously published.

Child↗
PubMedDate not supplied

[Value of isotopic cystography in the diagnosis of vesicoureteral reflux in childhood].

We have studied 62 children with urinary infection simultaneously by means of micturitional cystoureterography (MCU) and indirect isotopic cystography. We confirm a correlation between the results of the MCU and in the indirect isotopic cystography in 86% of the ureters explored, whilst the results of the MCU and of the direct isotopic cystography coincided in 92% of the ureters explored. We discuss the advantages and drawbacks of isotopic cystography, concluding that it is a suitable method for the diagnosis and evolutive control of vesicoureteral reflux in infancy.

Adolescent↗
PubMedDate not supplied

Idiopathic hypercalciuria: effects of calcium load test on magnesiuria.

Twenty-three children with idiopathic hypercalciuria and 7 control children were studied. Patients were classified into three groups according to the response to an oral calcium load. Five children displayed absorptive hypercalciuria (UCa/Cr 0.14 +/- 0.04 mg/mg with poor calcium diet and 0.33 +/- 0.16 after loading, p less than 0.01); 10 were classified renal hypercalciuria (UCa/Cr during the fasting state of 0.28 +/- 0.09 and 0.31 +/- 0.11 after loading) and 8 were classified as alimentary hypercalciuria (UCa/Cr 0.14 +/- 0.07 during the fasting state and 0.15 +/- 0.04 after loading). The urinary cAMP showed no significant differences in any of the three groups compared to the control. Magnesiuria did not show significant differences between the two forms of hypercalciuria and the control; a significant increase was observed after the loading and a positive correlation between magnesiuria and calciuria in the absorptive form. Our study supports the validity of the test for the classification of the different forms of hypercalciuria in children. The urinary cAMP is not a valid approach for classification. The difference observed in the magnesiuria suggests a different pathogenic mechanism between the two types of idiopathic hypercalciuria.

Administration, Oral↗