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Biomedical subjects

J Bringer

Publications and source records attributed to J Bringer.

At least 109 records · Page 6Linked to original sources
PubMed1986

[Stimulation of ovulation by pure FSH for in vitro fertilization. Study of the route of administration].

Pulsatile injection of FSH to stimulate ovulation for in vitro fertilization was undertaken in order to compare the intramuscular route with the pulsatile subcutaneous route in two groups of 6 patients each selected at random. The patients were selected in such a way as to reduce as far as possible the parameters that would make it difficult to interpret the results. Both from the point of view of the numbers of patients who responded to stimulation of ovulation as well as the numbers of pregnancies that were obtained, the intramuscular route seems to be preferable.

Adult↗
PubMed1985

[Urinary excretion of 3-methylhistidine. Value and application to the study of protein catabolism].

The urinary excretion of 3-methylhistidine (3 MH) is considered an easy and reliable method to quantify muscle protein catabolism in man. The 3 MH/creatinine (Cr) ratio is thought to be a good index of fractional degradation of muscle fibre protein. In the present article, the stress is placed on the limitations of 3 MH assays an- on their clinical applications. In thyroid diseases and in malnutrition (anorexia nervosa), the 3 MH/Cr ratio differentiates clearly marasmic malnutrition without increase in protein catabolism from hypercatabolic states, such as hyperthyroidism, with excessive protein degradation. 3 MH measurements therefore appear to be useful to determine the contribution of protein catabolism to lean mass reduction.

Adolescent↗
PubMed1985

Influence of the frequency of gonadotropin-releasing hormone (GnRH) administration on ovulatory responses in women with anovulation.

In attempt to optimize gonadotropin-releasing hormone (GnRH) treatment of anovulation, we compared the effect of intravenous GnRH administration at three pulse intervals (PI) during 63 cycles in 30 anovulatory patients who had: (1) amenorrhea secondary to anorexia nervosa (group I: 10 patients, 21 cycles); (2) unexplained anovulation with normal to high luteinizing hormone plasma levels (group II: 12 patients, 24 cycles); and (3) polycystic ovarian disease (PCOD) (group III: 8 patients, 18 cycles). Ovulation was achieved more frequently in group I (85%) than in group II (41%) or in group III (50%). In both groups I and II, the frequency of ovulatory responses was not different with the PI used, and 6 of the 17 women treated for infertility conceived; 3 with 90-minute PIs, 2 with 64-minute PIs, and 1 with 128-minute PIs. In women with PCOD, seven of the nine ovulatory responses and three pregnancies were obtained with 128-minute PIs. The overweight women with PCOD did not respond reliably to GnRH at the doses used, i.e., 4 to 15 micrograms per pulse. In all groups, the urinary estrone and estradiol preovulatory peak, duration of luteal phase, progesterone levels, and preovulatory follicle diameter were unrelated to the frequency of GnRH administration.

Anovulation↗
PubMed1985

[Enzymatic determination of urinary estrogens. A 5-year experience in a hospital milieu].

The enzymatic method for urinary estrogens determination from Nicolas et al. has become a useful tool for the management of infertility problems. It can be used for: investigation of ovarian by establishing the urinary estrogens profile during menstrual cycle, useful to: understand anomalies of the spontaneous cycle, explain some therapeutic failures during IVF attempts or artificial inseminations (AID or AIC); prediction of failures during IVF attempts during spontaneous cycles, and monitoring ovarian response during stimulated cycles in order to determine the trigger with hCG; monitoring ovulation during induction of ovulation in anovulatory patients stimulated with various drugs (clomiphene citrate, pure FSH combination of FSH and LH, GnRH ou analogs...) under various conditions of prescription and administration (oral, IM, intermittent pulsatile administration with portable pump with or without hypophyseal down regulation). This technique allows also exploration of androgens after changing main androgens (delta 4 A, T, DHEA, DHEA S) into estrogens through the action of placental aromatase, as well as appreciation of aromatase activity of some tissues in the presence of androgenic substrates. This paper gives the conclusions after 5 years of practice with this method and summaries different works published by the biologists who developed the method and by the clinicians who used its results.

Adolescent↗
PubMed1984

Thyroid status and muscle protein breakdown as assessed by urinary 3-methylhistidine excretion: study in thyrotoxic patients before and after treatment.

Urinary 3-methylhistidine (3MH) excretion was studied in nine thyrotoxic patients before and after treatment. Urinary creatinine (Cr) output was also measured and was low in the thyrotoxic subjects before treatment. Thus, although urinary output of 3MH was not greater than among the control population when expressed per subject, it was significantly elevated when expressed as the ratio of 3MH to Cr; this ratio fell significantly, reaching normal control values after a euthyroid state was obtained. In one patient who became hypothyroid, the 3MH/Cr ratio fell under the control value. There was a significant linear correlation between the 3MH/Cr ratio and the hormonal variables (T3, T4, FT4l); moreover, variations in the 3MH/Cr ratio and variations in the T3 level were closely correlated. 3-Methylhistidine appears to be a reliable index of muscular breakdown in thyrotoxicosis. From our results, it can be concluded, first of all, that hyperthyroidism is accompanied by an increased muscular catabolism, and, second, that the return to a euthyroid state results in an immediate normalization of muscular breakdown.

Adult↗
PubMed1983

[Efficaciousness of enteral feeding at continuous low flow in the treatment of anorexia nervosa].

Metabolic studies were performed in 8 of 14 patients with severe anorexia nervosa (AN) before and after nutritional therapy. The decrease of lean body mass, as judged by the low values of the creatinine-height index (CHI), and the normal levels of visceral proteins demonstrate the marasmic pattern of undernutrition in AN. Low 24-hour urinary 3-methylhistidine and urea levels agree with adaptation to malnutrition by decreasing in muscular breakdown. With enteral and oral feeding, weight gain was impressive and CHI reached normal values; 3-methylhistidine increased, reflecting enhancement of myofibrillar protein metabolism. By the end of refeeding, the levels of rapid-turnover proteins (prealbumin, retinol-binding protein) were higher than normal. Thus enteral feeding appears to be an efficient treatment of malnutrition in severe AN.

Adolescent↗
PubMed1982

[Comparative study of porcine and human regular insulins using an artificial pancreas].

Porcine extracted monocomponent insulins and human semi-synthetic insulins obtained by enzymatic conversion of porcine insulin had exactly the same clinical effectiveness on blood glucose balance when compared with an artificial pancreas during two 48-hour studies 2 or 3 days apart. There was no significant difference between maximum and minimum blood glucose variations, glycaemic falls and Schlichtkrull coefficient. Glycaemia increased and decreased during meals at a slightly slower rate with human insulin than with porcine insulin, but the differences were not significant. With both types of insulin therapy, insulin requirements per gram of ingested carbohydrates were proportionally more important in the morning than during the rest of the day, dans baseline requirements tended to increase during the day.

Animals↗
PubMed1982

[Metabolic adaptation to chronic denutrition in anorexia nervosa. Effects of realimentation. Value of the assay of urinary 3-methylhistidine].

Nutritional studies conducted in 9 patients suffering from anorexia nervosa showed a marasmus-like pattern with predominant depletion of lean body mass rather than of visceral proteins. In addition, adaptation to insufficient food intake led to a decrease in myofibrillar breakdown, as evidenced by low levels of urinary 3-methylhistidine. Low-flow enteral feeding resulted, within a few weeks, in return to normal of plasma proteins (particularly those with short half-life), while a dramatic increase in urinary 3-methylhistidine suggested acceleration of muscle protein turnover under adequate calorie-protein intake.

Adolescent↗
PubMed1981

[Type I multiple endocrine neoplasia with prolactin-secreting tumor revealed by pituitary apoplexy (author's transl)].

Prolactin-secreting adenoma is probably the most common functional pituitary tumour in type I multiple endocrine neoplasia (MEN I). The authors report on a case of gastrinoma and parathyroid adenoma associated with prolactinoma. The latter tumour was revealed by sudden pituitary apoplexy. The characteristic features of endocrine tumours in MEN 1 are discussed, and the relevant literature is reviewed. Emphasis is placed on the fact that prolactinomas are well tolerated, remain clinically silent for a long time and may be diagnosed only when dramatic symptoms suddenly appear.

Cerebrovascular Disorders↗
PubMed1981

[Post-hyperglycaemic hypoglycaemia: effects of somatostatin (author's transl)].

Precise recordings of reactive (post-hyperglycaemic) hypoglycaemia were ensured by continuous blood glucose monitoring during oral glucose tolerance tests. The definition of hypoglycaemia was limited to the following criteria: absence of chemical diabetes; fall in blood sugar to less than 30% of the fasting level or to less than 2.50 mmol/l (0.45 g/l); development of clinical signs of hypoglycaemia. An infusion of somatostatin over 4 hours slowed down the initial rise in blood sugar during the first 90 minutes and the rise was prolonged throughout the infusion whatever its duration. The maximum glycaemia reached was 13.3 mmol/l (2.40 g/l) at the 250th minute. Interruption of the infusion led to a rapid fall in blood sugar to a level identical (2.1 and 2.5 mmol/l) with and without somatostatin respectively. Somatostatin infusions, while frankly diabetogenic in certain circumstances, do not prevent reactive hypoglycaemia but rather delay its onset.

Adult↗
PubMed1981

Prevention of insulin aggregation by dicarboxylic amino acids during prolonged infusion.

The dicarboxylic amino acids, aspartic and glutamic acid, at their isoelectric pH, reduced aggregation of insulin solutions in vitro for 16 days during continuous agitation at 37 degrees C. Unprotected insulin solutions, when infused via a 14-day implantable infusion device in diabetic Chinese hamsters, controlled plasma glucose levels for only 2 days, followed by escape coincident with insulin aggregation. However, when insulin solutions were protected with glutamic acid, euglycemia was maintained for the 14-day life of the device.

Animals↗