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Biomedical subjects

J Brotchie

Publications and source records attributed to J Brotchie.

6 recordsLinked to original sources
PubMed2000

NMDA receptors in the basal ganglia.

The basal ganglia consist of several interconnected nuclei located in the telecephalon, diencephalon and mesencephalon that are involved in a variety of motor and non-motor behavioural functions. Glutamate receptors play a major role in neurotransmission within the basal ganglia and are present in all nuclei of the basal ganglia. This review focuses on the contribution of the NMDA class of glutamatergic receptors to various movement disorders whose primary pathology lies within the basal ganglia and discusses how pharmacological manipulation of such receptors may be therapeutically useful.

Basal Ganglia↗
PubMed1996

Normethylclozapine potentiates the action of quinpirole in the 6-hydroxydopamine lesioned rat.

Systemic administration of the 5-HT2c receptor antagonist, normethylclozapine, to previously untreated unilaterally 6-hydroxydopamine-lesioned rats elicits rotations contraversive to the lesion when given with a subthreshold dose of the dopamine D2 receptor agonist, quinpirole. Normethylclozapine alone does not possess any anti-parkinsonian action. In animals which have previously received dopamine replacement therapy, i.e. primed, normethylclozapine potentiates the contraversive rotations induced by quinpirole. We speculate that these actions may result from reduced excitation of the output regions of the basal ganglia. 5-HT2c receptor antagonists may have potential as treatment for Parkinson's disease in combination with dopamine receptor agonists.

Animals↗
PubMed1987

Reminiscence: a critical review of the empirical literature.

The empirical evidence concerning the prevalence and function of reminiscence among the elderly is reviewed and the relevance of such activity for clinical populations is evaluated. Variations in the ways in which reminiscence is defined and methods of eliciting reminiscence activity are described. Data on frequency of reminiscence and its relationship to age are discussed. Studies investigating the functions of reminiscence are divided into three groups according to experimental design and their findings critically reviewed. It is concluded that there is little evidence of an age-specific process of reminiscence, that the functions of such a process are unclear and that the role of reminiscence as a therapeutic activity is in doubt.

Adolescent↗
PubMed1985

Temporal orientation in the pre-senium and old age.

Temporal orientation in 235 normal elderly subjects was examined and compared with previous results from a young adult population. Orientation for time in the elderly remains reasonably intact; the major exception to this was inaccurate recall of the date, which was most pronounced among women in the older group studied (71 +).

Aged↗