Biomedical subjects

J Buchmann

Publications and source records attributed to J Buchmann.

At least 19 recordsLinked to original sources

PubMed1990

[Steroid receptors in the gestagen treatment of endometriosis].

In 35 patients with laparoscopically proved endometriosis we determined the cytosolic estrogen and progesterone receptor content in endometrial samples before and after a 3-month course of progestagen treatment (DCC method). Dienogest was given in 20 cases, norethisterone in an other group of 15 patients. Compared with a normal group the receptor content was clearly higher in endometriosis patients. It correlated closely to the histological findings dated according to Noyes. In more than 60% of the pretherapeutic cycles there were some signs of disturbed differentiation. After 3 month of therapy the binding capacity of steroid receptors significantly decreased, particularly in norethisterone patients. Both clinical results and receptor conditions correspond to previous investigations concerning the competition behaviour, having confirmed different binding affinity to the receptor for the two gestagens here tested.

Adult↗

PubMed1989

[Microinvasive stage Ia cancer of the uterine cervix--results of a multicenter clinic based analysis].

A retrospective multicentre study to investigate diagnosis, treatment and end results of treatment of cervical cancer stage Ia, was carried out in 6 departments of gynaecological oncology. After reclassification by a reference pathologist, among the 936 cervical cancer cases primarily diagnosed and treated as stage Ia between 1970 and 1980, only 530 (56.6%) met the criteria of microinvasive cancer stage Ia. Misclassifications concerned all participating centres with statistically significant differences amongst them. Overdiagnosis (reference diagnosis only CIN I-III, 42.5%) was more frequent than underdiagnosis (reference diagnosis stage Ib--0.9%). In comparison to 1970-74, in the period 1975-80 a significant increase of cases detected asymptomatically (86.5%) was observed. The percentage of cases primarily diagnosed by cone biopsy, also increased significantly and amounted to 71.2%. Patients with cervical cancer stage Ia were most frequently treated by surgery alone (93.2%). Radiotherapy alone did not play any important role (5.7%). There were only a few cases treated by combined surgery and radiotherapy (5.7%) with a decreasing trend over time. Women under the age of 45 years were significantly more frequently treated by the conservative method (cone biopsy, simple hysterectomy) than older ones, without any significant relation between depth of invasion and radicality of treatment. A total of 19 (14 local, 5 lymph node) recurrences were diagnosed between 9 and 110 months after primary treatment. Local recurrences could be observed more frequently after limited than extended treatment. There was no significant relation between depth of invasion and frequency of recurrences, but the latter were significantly increased in cases with histologically proven invasion of blood or lymph vessels.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗

PubMed1988

[Menstrual cycle stimulation in the in vitro fertilization program--effects on estrogen and progesterone receptors of the endometrium].

Clomiphene in combination with human menopausal gonadotropin (HMG) or HMG alone was used for ovarian stimulation in the IVF program. In 41 cases without embryo transfer (ova could not be obtained or fertilised) 7-8 days after laparoscopy on endometrial biopsy was performed. Serum steroid hormone levels were estimated at the same day and in the time before follicular puncture. Histological classification of the received endometrium and the determination of the kinetic parameters of cytosolic estrogen and progesterone receptors were carried out. A strong correlation exists between histological results and receptor properties. Luteal phase defects are not only connected with a significant decrease of receptor binding capacity but also an increase of the dissociation constants occurs. Clomiphene HMG treatment results in general reduction of binding affinity of the cytosolic estrogen receptor. No correlation was found between the serum hormone levels at day of biopsy and the endometrial histology or receptor parameters on the other hand.

Clomiphene↗

PubMed1984