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J C Addonizio

Publications and source records attributed to J C Addonizio.

At least 37 records · Page 2Linked to original sources
PubMed1987

Ultrasonic aspiration of prostate, bladder tumors, and stones. Progress report.

The projected advantages of ultrasonic surgery on prostate, bladder tumors, and stones are: (1) precise histologic diagnosis without microscopic distortion as occurs with electrocautery; (2) continuous uninterrupted surgery; (3) improved hemostasis; (4) protection of external sphincter; (5) easy surgical technique to learn; (6) adaptability for video TUR; (7) can remove bladder stones and perform TURP at one sitting; (8) no fear of bladder wall injury during lithotripsy since stone is sucked to aspirator for dissolution; (9) no electrical burns or obturator reflex since electricity is not used to resect.

Humans↗
PubMed1987

Prostatic invasion of rectal carcinoma: does transurethral surgery alter prognosis?

Two cases of colorectal carcinoma invading the prostate are presented. Each patient initially had an abdominoperineal resection for colorectal carcinoma followed by a transurethral resection of the prostate (TURP) for benign prostatic disease. In both patients colonic carcinoma developed subsequently in their prostatic fossae. Pathogenesis of late tumor invasion into the prostate is reviewed and consideration given to a more conservative surgical approach.

Adenocarcinoma, Mucinous↗
PubMed1987

Monocyte cytolytic factor in promoting monocyte-mediated lysis of bladder cancer cells by bacillus Calmette-Guerin.

The role of monocytes in cell-mediated cytolysis of bladder cancer cells was investigated. Human peripheral monocytes released a cytolytic factor which lysed T24 bladder cancer cells and a number of human tumor cells, but not normal lymphocytes or fibroblasts. After incubation of monocytes with bacillus Calmette-Guerin for 48 hr. in vitro, cytolysis of T24 cells was increased up to 56.7 +/- 4.1%. Treatment of monocytes with actinomycin D (an inhibitor of RNA transcription) reduced release of cytolytic factor from 27.3 +/- 5.7% cytolysis to 4.5 +/- 1.4% (p less than 0.05). The response to mitomycin C was different between lymphokines and monocyte cytolytic factor. The mouse monoclonal antibody against human recombinant tumor necrosis factor did not neutralize monocyte cytolytic factor. These results show that this monocyte cytolytic factor is distinct from lymphokines and tumor necrosis factor. The evidence that bacillus Calmette-Guerin increases release of monocyte cytolytic factor may be associated with anti-tumor activity of bacillus Calmette-Guerin in intravesical therapy for treatment of bladder cancer.

Cell Line↗
PubMed1986

Methylmethacrylate upper ureteral obstruction.

A case of upper ureteral obstruction caused by methylmethacrylate cement after fixation of an L2-L3 vertebral fracture is reported. The probable mechanism, radiographic findings, and management of this complication are reviewed.

Female↗
PubMed1986

Cavitrons in urologic surgery.

The CUSA is a unique modality for precise removal of tissue. This ultrasonic scalpel represents a major technical advance in surgery by providing a small handpiece device that can selectively remove tissue in a controlled manner. The usefulness of this modality in removing parenchymal tissue while sparing vascular or ductal structures is outstanding. Laboratory and clinical experience have demonstrated that utilization of this scalpel, particularly in vascular organs and lesions, provides the surgeon with increased visibility, reduced bleeding, and shorter operating time. Our application of this instrument in the performance of renal surgery in dogs as well as in the clinical setting has been well documented. Its future application as a surgical tool in the armamentarium of the urologist is uncertain and awaits the outcome of future studies.

Animals↗
PubMed1985

Heterogeneity index score (HIS). New computerized method for classification of human bladder carcinomas using flow cytometry.

The rationale for studying nuclear DNA may be its direct relationship to the aggressiveness of cancer. Recent flow cytometric studies (FCM) of cancer cells show the limitation of the current methods for the accurate determination of the degree of aneuploidy or proliferative characteristics of a tumor cell. Here we report a new methodology for a computerized determination which is well correlated with relative mean DNA content in cell populations analyzed by FCM (heterogeneity index, HI). A total of seventy-six tissue samples were examined. Twenty-two specimens were benign tissue while fifty-four were histologically malignant bladder tumors. Forty tumors were grade (G)I-II, ten G-III, and four carcinoma in situ. The samples were mechanically minced into a single cell suspension and stained with propidium iodide. An Ortho system 50-H multiparameter flow cytometer equipped with an Ortho 2150 computer was used to determine DNA content and cell number. HI was calculated using the following formulas: (formula; see text) The mean HIS of twenty-two normal and benign tissues was 9.805 +/- 5.6. The forty G-II tumors had a mean HIS of 23.576 +/- 26.519. Statistical differences were observed between benign tissue and G-I-II tumors (P = 0.0196). G-III tumors had a marked increase in HIS of 160.965 +/- 63.404. The limited study of four carcinoma in situ tumors showed a mean HIS of 45.4 +/- 9.5. Our computer extrapolation of flow cytometric DNA analysis quantifies an objective description of FCM characteristics and histochemical index which may distinguish the degree of tumor malignancy.

Carcinoma↗
PubMed1985

Ureteral replacement using collagen sponge tube grafts.

The use of a collagen sponge tube graft as a material for segmental ureteral replacement was investigated. The structural design of the collagen sponge graft was achieved by cell culture on the matrix. MGH-U1 cells, derived from bladder cell carcinoma, were grown in vitro on the collagen sponge matrix with excellent biocompatibility and without evidence of cytotoxicity. The collagen sponge demonstrated biodegradability when implanted subcutaneously in dogs. However, a urine exposure test of collagen sponge in rat bladders revealed extensive salt deposits on its surface in some rats, as observed by crystallographic examination. Segmental ureteral replacements by collagen sponge tube grafts, accompanied by ureteral splint catheters, were performed in dogs. There was extensive uro-epithelial cell regeneration on the inner surface of the collagen grafts, without evidence of severe hydronephrosis, 5 to 12 weeks following the procedure. The results indicate the potential for ureteral replacement by collagen sponge tube grafts, which would act as non-toxic, biodegradable scaffolds inducing the regenerative activity of the ureter.

Animals↗
PubMed1984

Cavitron ultrasonic surgical aspirator. Applications in urologic surgery.

The Cavitron Ultrasonic Surgical Aspirator is a unique modality for precise tissue removal which results in increased visibility, reduced bleeding, and shorter operating time when dealing with vascular lesions or organs. Herein, we present our experience in a dog laboratory as well as in a clinical setting with this new instrument. The mechanism of action, proper surgical technique required, and further application in urologic surgery are discussed.

Animals↗
PubMed1984

Embryonal carcinoma of testis in elderly men.

A rare case of pure embryonal carcinoma of the testis in a man in the seventh decade of his life is presented. We believe this is the only reported long-term survivor of embryonal carcinoma of the testis in this age group. A review of the literature on germ cell testicular tumor in men sixty years old and over is also presented.

Aged↗